Bugs and irritable bowel syndrome: The good, the bad and the ugly

Uday C. Ghoshal, Hyojin Park, Kok Ann Gwee

Research output: Contribution to journalReview article

60 Citations (Scopus)

Abstract

Recently, there has been strong interest in the therapeutic potential of probiotics for irritable bowel syndrome (IBS). At the same time, there is a rapidly growing body of evidence to support an etiological role for gastrointestinal infection and the associated immune activation in the development of post-infectious IBS. In a more controversial area, small intestinal bacterial overgrowth has been associated with a subset of patients with IBS; the issue of whether it is appropriate to treat a subset of IBS patients with antibiotics and probiotics is currently a matter for debate. Thus, it appears that the gastrointestinal microbial flora may exert beneficial effects for symptoms of IBS under some circumstances, while in other situations gut microbes could give rise to symptoms of IBS. How do we make sense of the apparently diverse roles that 'bugs' may play in IBS? To address this question, we have conducted an in-depth review, attempting where possible to draw lessons from Asian studies.

Original languageEnglish
Pages (from-to)244-251
Number of pages8
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume25
Issue number2
DOIs
Publication statusPublished - 2010 Feb

Fingerprint

Irritable Bowel Syndrome
Probiotics
Anti-Bacterial Agents
Infection

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

@article{25ea695ea80c4f20ae63ba58aee9b0a3,
title = "Bugs and irritable bowel syndrome: The good, the bad and the ugly",
abstract = "Recently, there has been strong interest in the therapeutic potential of probiotics for irritable bowel syndrome (IBS). At the same time, there is a rapidly growing body of evidence to support an etiological role for gastrointestinal infection and the associated immune activation in the development of post-infectious IBS. In a more controversial area, small intestinal bacterial overgrowth has been associated with a subset of patients with IBS; the issue of whether it is appropriate to treat a subset of IBS patients with antibiotics and probiotics is currently a matter for debate. Thus, it appears that the gastrointestinal microbial flora may exert beneficial effects for symptoms of IBS under some circumstances, while in other situations gut microbes could give rise to symptoms of IBS. How do we make sense of the apparently diverse roles that 'bugs' may play in IBS? To address this question, we have conducted an in-depth review, attempting where possible to draw lessons from Asian studies.",
author = "Ghoshal, {Uday C.} and Hyojin Park and Gwee, {Kok Ann}",
year = "2010",
month = "2",
doi = "10.1111/j.1440-1746.2009.06133.x",
language = "English",
volume = "25",
pages = "244--251",
journal = "Journal of Gastroenterology and Hepatology (Australia)",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "2",

}

Bugs and irritable bowel syndrome : The good, the bad and the ugly. / Ghoshal, Uday C.; Park, Hyojin; Gwee, Kok Ann.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 25, No. 2, 02.2010, p. 244-251.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Bugs and irritable bowel syndrome

T2 - The good, the bad and the ugly

AU - Ghoshal, Uday C.

AU - Park, Hyojin

AU - Gwee, Kok Ann

PY - 2010/2

Y1 - 2010/2

N2 - Recently, there has been strong interest in the therapeutic potential of probiotics for irritable bowel syndrome (IBS). At the same time, there is a rapidly growing body of evidence to support an etiological role for gastrointestinal infection and the associated immune activation in the development of post-infectious IBS. In a more controversial area, small intestinal bacterial overgrowth has been associated with a subset of patients with IBS; the issue of whether it is appropriate to treat a subset of IBS patients with antibiotics and probiotics is currently a matter for debate. Thus, it appears that the gastrointestinal microbial flora may exert beneficial effects for symptoms of IBS under some circumstances, while in other situations gut microbes could give rise to symptoms of IBS. How do we make sense of the apparently diverse roles that 'bugs' may play in IBS? To address this question, we have conducted an in-depth review, attempting where possible to draw lessons from Asian studies.

AB - Recently, there has been strong interest in the therapeutic potential of probiotics for irritable bowel syndrome (IBS). At the same time, there is a rapidly growing body of evidence to support an etiological role for gastrointestinal infection and the associated immune activation in the development of post-infectious IBS. In a more controversial area, small intestinal bacterial overgrowth has been associated with a subset of patients with IBS; the issue of whether it is appropriate to treat a subset of IBS patients with antibiotics and probiotics is currently a matter for debate. Thus, it appears that the gastrointestinal microbial flora may exert beneficial effects for symptoms of IBS under some circumstances, while in other situations gut microbes could give rise to symptoms of IBS. How do we make sense of the apparently diverse roles that 'bugs' may play in IBS? To address this question, we have conducted an in-depth review, attempting where possible to draw lessons from Asian studies.

UR - http://www.scopus.com/inward/record.url?scp=76149140061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76149140061&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1746.2009.06133.x

DO - 10.1111/j.1440-1746.2009.06133.x

M3 - Review article

C2 - 20074148

AN - SCOPUS:76149140061

VL - 25

SP - 244

EP - 251

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

IS - 2

ER -