Burkholderia sepsis in children as a hospital-acquired infection

Kyu Yeun Kim, Dongeun Yong, Kyungwon Lee, Ho Seong Kim, Dong Soo Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Hospital-acquired Burkholderia cepacia (B. cepacia) infection are not commonly recorded in patients without underlying lung disease, such as cystic fibrosis and chronic granulomatous disease. However, in 2014, B. cepacia appeared more frequently in pediatric blood samples than in any other year. In order to access this situation, we analyzed the clinical characteristics of B. cepacia infections in pediatric patients at our hospital. Materials and Methods: We conducted a retrospective study of blood isolates of B. cepacia taken at our hospital between January 2004 and December 2014. Patient clinical data were obtained by retrospective review of electronic medical records. We constructed a dendrogram for B. cepacia isolates from two children and five adult patients. Results: A total of 14 pediatric patients and 69 adult patients were identified as having B. cepacia bacteremia. In 2014, higher rates of B. cepacia bacteremia were observed in children. Most of them required Intensive Care Unit (ICU) care (12/14). In eleven children, sputum cultures were examined, and five of these children had the same strain of B. cepacia that grew out from their blood samples. Antibiotics were administered based on antibiotic sensitivity results. Four children expired despite treatment. Compared to children, there were no demonstrative differences in adults, except for history of ICU care. Conclusion: Although there were not many pediatric cases at our hospital, awareness of colonization through hospital-acquired infection and effective therapy for infection of B. cepacia is needed, as it can cause mortality and morbidity.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalYonsei medical journal
Volume57
Issue number1
DOIs
Publication statusPublished - 2016 Jan

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Burkholderia
Burkholderia cepacia
Cross Infection
Sepsis
Burkholderia Infections
Pediatrics
Bacteremia
Intensive Care Units
Anti-Bacterial Agents
Chronic Granulomatous Disease
Electronic Health Records
Sputum
Cystic Fibrosis
Lung Diseases
Retrospective Studies
Morbidity

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, Kyu Yeun ; Yong, Dongeun ; Lee, Kyungwon ; Kim, Ho Seong ; Kim, Dong Soo. / Burkholderia sepsis in children as a hospital-acquired infection. In: Yonsei medical journal. 2016 ; Vol. 57, No. 1. pp. 97-102.
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abstract = "Purpose: Hospital-acquired Burkholderia cepacia (B. cepacia) infection are not commonly recorded in patients without underlying lung disease, such as cystic fibrosis and chronic granulomatous disease. However, in 2014, B. cepacia appeared more frequently in pediatric blood samples than in any other year. In order to access this situation, we analyzed the clinical characteristics of B. cepacia infections in pediatric patients at our hospital. Materials and Methods: We conducted a retrospective study of blood isolates of B. cepacia taken at our hospital between January 2004 and December 2014. Patient clinical data were obtained by retrospective review of electronic medical records. We constructed a dendrogram for B. cepacia isolates from two children and five adult patients. Results: A total of 14 pediatric patients and 69 adult patients were identified as having B. cepacia bacteremia. In 2014, higher rates of B. cepacia bacteremia were observed in children. Most of them required Intensive Care Unit (ICU) care (12/14). In eleven children, sputum cultures were examined, and five of these children had the same strain of B. cepacia that grew out from their blood samples. Antibiotics were administered based on antibiotic sensitivity results. Four children expired despite treatment. Compared to children, there were no demonstrative differences in adults, except for history of ICU care. Conclusion: Although there were not many pediatric cases at our hospital, awareness of colonization through hospital-acquired infection and effective therapy for infection of B. cepacia is needed, as it can cause mortality and morbidity.",
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Burkholderia sepsis in children as a hospital-acquired infection. / Kim, Kyu Yeun; Yong, Dongeun; Lee, Kyungwon; Kim, Ho Seong; Kim, Dong Soo.

In: Yonsei medical journal, Vol. 57, No. 1, 01.2016, p. 97-102.

Research output: Contribution to journalArticle

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