Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine

Dong Nyoung Heo, Dae Hyeok Yang, Jung Bok Lee, Min Soo Bae, Jung Ho Kim, seonghwan moon, Heoung Jae Chun, Chun Ho Kim, Ho Nam Lim, Il Keun Kwon

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Despite the fact that advances of burn treatment have led to reduction in the morbidity caused by burns, burn infection is still a serious problem. In this study, we designed blended synthetic and natural polymers nanofiber scaffolds using polyurethane (PU) and gelatin, which were prepared by an electrospinning method. Silver-sulfadiazine (SSD) was comixed to the blended polymer solution for being incorporated into the nanofibers after the electrospinning, followed by examination of burn-wound healing effect. The nanofiber scaffolds containing SSD should not only serve as a substrate for skin regeneration, but may also deliver suitable drugs, within a controlled manner during healing. The SSD release was able to prevent the growth of a wide array of bacteria and accelerate the wound healing by preventing infection. Therefore it could accelerate the burn-wound closure rate. We confirmed that PU/gelatin nanofiber scaffolds containing SSD lead to enhanced regeneration of burn-wounds.

Original languageEnglish
Pages (from-to)511-515
Number of pages5
JournalJournal of Biomedical Nanotechnology
Volume9
Issue number3
DOIs
Publication statusPublished - 2013 Mar 1

Fingerprint

Silver Sulfadiazine
Nanofibers
Polyurethanes
Gelatin
Burns
Scaffolds
Wound Healing
Silver
Electrospinning
Regeneration
Polymers
Natural polymers
Wounds and Injuries
Polymer solutions
Infection
Bacteria
Skin
Morbidity
Substrates
Growth

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

Heo, Dong Nyoung ; Yang, Dae Hyeok ; Lee, Jung Bok ; Bae, Min Soo ; Kim, Jung Ho ; moon, seonghwan ; Chun, Heoung Jae ; Kim, Chun Ho ; Lim, Ho Nam ; Kwon, Il Keun. / Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine. In: Journal of Biomedical Nanotechnology. 2013 ; Vol. 9, No. 3. pp. 511-515.
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Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine. / Heo, Dong Nyoung; Yang, Dae Hyeok; Lee, Jung Bok; Bae, Min Soo; Kim, Jung Ho; moon, seonghwan; Chun, Heoung Jae; Kim, Chun Ho; Lim, Ho Nam; Kwon, Il Keun.

In: Journal of Biomedical Nanotechnology, Vol. 9, No. 3, 01.03.2013, p. 511-515.

Research output: Contribution to journalArticle

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