Abstract
We retrospectively examined the outcomes of 56 patients with diffuse large B-cell lymphoma (DLBCL) who underwent autologous stem cell transplant (ASCT) with BEAM/BEAC (carmustine, etoposide, cytarabine, melphalan/cyclophosphamide) or busulfan (Bu)-containing conditioning regimens. The Bu group had lower disease-related mortality and more frequent achievement of complete remission (CR) after ASCT from partial remission (PR) or refractory status before ASCT compared with the BEAM/BEAC group. The estimated 2-year EFS (59.3% vs. 15.0%) and overall survival (OS) (70.2% vs. 42.0%) in pre-ASCT rituximab-exposed patients with DLBCL were higher in the Bu group. In patients with high-risk DLBCL exposed to rituximab with first remission, the Bu group had better EFS (p = 0.004) and OS (p = 0.053) rates, while survival rates for relapsed/refractory patients did not differ between groups. Bu regimens are highly effective for preparing patients with DLBCL with previous exposure to rituximab for ASCT, especially in high-risk patients who achieved a first remission.
Original language | English |
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Pages (from-to) | 2490-2496 |
Number of pages | 7 |
Journal | Leukemia and Lymphoma |
Volume | 55 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2014 Nov 1 |
Bibliographical note
Funding Information:This work was supported by a 2-year Research Grant of Pusan National University.
Publisher Copyright:
© 2014 Informa UK, Ltd.
All Science Journal Classification (ASJC) codes
- Hematology
- Oncology
- Cancer Research