C. elegans: An invaluable model organism for the proteomics studies of the cholesterol-mediated signaling pathway

Young Ki Paik, Seul Ki Jeong, Eun Young Lee, Pan Young Jeong, Yhong Hee Shim

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

With the availability of its complete genome sequence and unique biological features relevant to human disease, Caenorhabditis elegans has become an invaluable model organism for the studies of proteomics, leading to the elucidation of nematode gene function. A journey from the genome to proteome of C. elegans may begin with preparation of expressed proteins, which enables a large-scale analysis of all possible proteins expressed under specific physiological conditions. Although various techniques have been used for proteomic analysis of C. elegans, systematic high-throughput analysis is still to come in order to accommodate studies of post-translational modification and quantitative analysis. Given that no integrated C. elegans protein expression database is available, it is about time that a global C. elegans proteome project is launched through which datasets of transcriptomes, protein-protein interaction and functional annotation can be integrated. As an initial target of a pilot project of the C. elegans proteome project, the cholesterol-mediated signaling pathway will be an excellent example since, like in other organisms, it is one of the key controlling pathways in cell growth and development in C. elegans. As this field tends to broaden to functional proteomics, there is a high demand to develop the versatile proteome informatics tools that can mange many different data in an integrative manner.

Original languageEnglish
Pages (from-to)439-453
Number of pages15
JournalExpert Review of Proteomics
Volume3
Issue number4
DOIs
Publication statusPublished - 2006 Aug 21

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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