c-erbB-2 oncoprotein assay in ovarian carcinoma and its clinical correlation with prognostic factors

Young Tae Kim, Jae Wook Kim, Jung Woon Lee

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Overexpression of the c-erbB-2 oncoprotein has been detected in human adenocarcinoma of the breast, cervix and salivary gland, in all of which an association between the overexpression of the c-erbB-2 and a poor prognosis of the disease has been reported. However, the prognostic role of c-erbB-2 oncoprotein in ovarian carcinoma remains controversial. We measured c-erbB-2 oncoprotein with an enzyme-linked immunosorbent assay (ELISA). Patients with invasive ovarian cancer were found to have significantly higher median c-erbB-2 oncoprotein expression than patients with either benign ovarian cyst (P=0.002) or control groups (P=0.001). Overexpression of c-erbB-2 oncoprotein was found in seven (21.9%) of 32 epithelial ovarian cancers. Our results suggest that quantitative analysis of c-erbB-2 oncoprotein may be used to define the prognostic significance of ovarian carcinoma. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalCancer Letters
Volume132
Issue number1-2
DOIs
Publication statusPublished - 1998 Oct 23

Bibliographical note

Funding Information:
This study was supported by a Yonsei University Faculty Research Grant for 1996.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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