Abstract
Overexpression of the c-erbB-2 oncoprotein has been detected in human adenocarcinoma of the breast, cervix and salivary gland, in all of which an association between the overexpression of the c-erbB-2 and a poor prognosis of the disease has been reported. However, the prognostic role of c-erbB-2 oncoprotein in ovarian carcinoma remains controversial. We measured c-erbB-2 oncoprotein with an enzyme-linked immunosorbent assay (ELISA). Patients with invasive ovarian cancer were found to have significantly higher median c-erbB-2 oncoprotein expression than patients with either benign ovarian cyst (P=0.002) or control groups (P=0.001). Overexpression of c-erbB-2 oncoprotein was found in seven (21.9%) of 32 epithelial ovarian cancers. Our results suggest that quantitative analysis of c-erbB-2 oncoprotein may be used to define the prognostic significance of ovarian carcinoma. Copyright (C) 1998 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 91-97 |
| Number of pages | 7 |
| Journal | Cancer Letters |
| Volume | 132 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 1998 Oct 23 |
Bibliographical note
Funding Information:This study was supported by a Yonsei University Faculty Research Grant for 1996.
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
