C-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma

Chul Ho Kim, Yoon Woo Koh, Jae Ho Han, Jae Wook Kim, Jin Seok Lee, Seung Jae Baek, Hye Sook Hwang, Eun Chang Choi

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35 Citations (Scopus)

Abstract

Background: Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT). Methods Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT. Results The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p =.005), tumor classification (p =.004), and recurrence (p =.018). Survival was significantly affected in patients with positive c-Met expression (p =.003). HGF and c-Met were strongly expressed in cancer tissues on Western blot. Conclusion The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT.

Original languageEnglish
Pages (from-to)1655-1664
Number of pages10
JournalHead and Neck
Volume32
Issue number12
DOIs
Publication statusPublished - 2010 Dec

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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    Kim, C. H., Koh, Y. W., Han, J. H., Kim, J. W., Lee, J. S., Baek, S. J., Hwang, H. S., & Choi, E. C. (2010). C-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma. Head and Neck, 32(12), 1655-1664. https://doi.org/10.1002/hed.21383