C-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma

Chul Ho Kim, Yoonwoo Koh, Jae Ho Han, Jae Wook Kim, Jin Seok Lee, Seung Jae Baek, Hye Sook Hwang, Eun Chang Choi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT). Methods Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT. Results The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p =.005), tumor classification (p =.004), and recurrence (p =.018). Survival was significantly affected in patients with positive c-Met expression (p =.003). HGF and c-Met were strongly expressed in cancer tissues on Western blot. Conclusion The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT.

Original languageEnglish
Pages (from-to)1655-1664
Number of pages10
JournalHead and Neck
Volume32
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Hepatocyte Growth Factor
Tongue
Squamous Cell Carcinoma
Carcinoma
Survival
Neoplasms
Western Blotting
Lymph Nodes
Immunohistochemistry
Staining and Labeling
Neoplasm Metastasis
Recurrence

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Kim, C. H., Koh, Y., Han, J. H., Kim, J. W., Lee, J. S., Baek, S. J., ... Choi, E. C. (2010). C-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma. Head and Neck, 32(12), 1655-1664. https://doi.org/10.1002/hed.21383
Kim, Chul Ho ; Koh, Yoonwoo ; Han, Jae Ho ; Kim, Jae Wook ; Lee, Jin Seok ; Baek, Seung Jae ; Hwang, Hye Sook ; Choi, Eun Chang. / C-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma. In: Head and Neck. 2010 ; Vol. 32, No. 12. pp. 1655-1664.
@article{738b10d9bb624fe88b360be9e22b43f0,
title = "C-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma",
abstract = "Background: Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT). Methods Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT. Results The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3{\%} and 54.1{\%}, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p =.005), tumor classification (p =.004), and recurrence (p =.018). Survival was significantly affected in patients with positive c-Met expression (p =.003). HGF and c-Met were strongly expressed in cancer tissues on Western blot. Conclusion The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT.",
author = "Kim, {Chul Ho} and Yoonwoo Koh and Han, {Jae Ho} and Kim, {Jae Wook} and Lee, {Jin Seok} and Baek, {Seung Jae} and Hwang, {Hye Sook} and Choi, {Eun Chang}",
year = "2010",
month = "12",
day = "1",
doi = "10.1002/hed.21383",
language = "English",
volume = "32",
pages = "1655--1664",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",
number = "12",

}

Kim, CH, Koh, Y, Han, JH, Kim, JW, Lee, JS, Baek, SJ, Hwang, HS & Choi, EC 2010, 'C-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma', Head and Neck, vol. 32, no. 12, pp. 1655-1664. https://doi.org/10.1002/hed.21383

C-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma. / Kim, Chul Ho; Koh, Yoonwoo; Han, Jae Ho; Kim, Jae Wook; Lee, Jin Seok; Baek, Seung Jae; Hwang, Hye Sook; Choi, Eun Chang.

In: Head and Neck, Vol. 32, No. 12, 01.12.2010, p. 1655-1664.

Research output: Contribution to journalArticle

TY - JOUR

T1 - C-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma

AU - Kim, Chul Ho

AU - Koh, Yoonwoo

AU - Han, Jae Ho

AU - Kim, Jae Wook

AU - Lee, Jin Seok

AU - Baek, Seung Jae

AU - Hwang, Hye Sook

AU - Choi, Eun Chang

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Background: Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT). Methods Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT. Results The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p =.005), tumor classification (p =.004), and recurrence (p =.018). Survival was significantly affected in patients with positive c-Met expression (p =.003). HGF and c-Met were strongly expressed in cancer tissues on Western blot. Conclusion The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT.

AB - Background: Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT). Methods Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT. Results The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p =.005), tumor classification (p =.004), and recurrence (p =.018). Survival was significantly affected in patients with positive c-Met expression (p =.003). HGF and c-Met were strongly expressed in cancer tissues on Western blot. Conclusion The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT.

UR - http://www.scopus.com/inward/record.url?scp=78649672549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649672549&partnerID=8YFLogxK

U2 - 10.1002/hed.21383

DO - 10.1002/hed.21383

M3 - Article

VL - 32

SP - 1655

EP - 1664

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 12

ER -