C-reactive protein concentration is associated with a higher risk of mortality in a rural Korean population

Jung Hyun Lee, Hyungseon Yeom, HyeonChang Kim, Il Suh, Mi Kyung Kim, Min Ho Shin, Dong Hoon Shin, Sangbaek Koh, Songvogue Ahn, Tae Yong Lee, So Yeon Ryu, Jae Sok Song, Hong Soon Choe, Young Hoon Lee, Bo Youl Choi

Research output: Contribution to journalArticle

Abstract

Objectives: C-reactive protein (CRP), an inflammatory biomarker, has been widely used as a preclinical marker predictive of morbidity and mortality. Although many studies have reported a positive association between CRP and mortality, uncertainty still remains about this association in various populations, especially in rural Korea. Methods: A total of 23 233 middle-aged participants (8862 men and 14 371 women) who were free from cardiovascular disease, cancer, and acute inflammation (defined by a CRP level =10 mg/L) were drawn from 11 rural communities in Korea between 2005 and 2011. Blood CRP concentration was analyzed as a categorical variable (low: 0.0-0.9 mg/L; intermediate: 1.0-3.0 mg/L; high: 3.1-9.9 mg/L) as well as a continuous variable. Each participant's vital status through December 2013 was confirmed by death statistics from the National Statistical Office. Cox proportional hazard models were used to assess the independent association between CRP and mortality after adjusting for other risk factors. Results: The total quantity of observed person-years was 57 975 for men and 95 146 for women, and the number of deaths was 649 among men and 367 among women. Compared to the low-CRP group, the adjusted hazard ratio for all-cause mortality of the intermediate group was 1.17 (95% confidence interval [CI], 0.98 to 1.40) for men and 1.27 (95% CI, 1.01 to 1.61) for women, and the corresponding values for the high-CRP group were 1.98 (95% CI, 1.61 to 2.42) for men and 1.41 (95% CI, 1.03 to 1.95) for women. Similar trends were found for CRP evaluated as a continuous variable and for cardiovascular mortality. Conclusions: Higher CRP concentrations were associated with higher mortality in a rural Korean population, and this association was more prominent in men than in women.

Original languageEnglish
Pages (from-to)275-287
Number of pages13
JournalJournal of Preventive Medicine and Public Health
Volume49
Issue number5
DOIs
Publication statusPublished - 2016 Sep 1

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Rural Population
C-Reactive Protein
Mortality
Confidence Intervals
Korea
Proportional Hazards Models
Uncertainty
Blood Proteins
Cardiovascular Diseases
Biomarkers
Inflammation
Morbidity

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Lee, Jung Hyun ; Yeom, Hyungseon ; Kim, HyeonChang ; Suh, Il ; Kim, Mi Kyung ; Shin, Min Ho ; Shin, Dong Hoon ; Koh, Sangbaek ; Ahn, Songvogue ; Lee, Tae Yong ; Ryu, So Yeon ; Song, Jae Sok ; Choe, Hong Soon ; Lee, Young Hoon ; Choi, Bo Youl. / C-reactive protein concentration is associated with a higher risk of mortality in a rural Korean population. In: Journal of Preventive Medicine and Public Health. 2016 ; Vol. 49, No. 5. pp. 275-287.
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title = "C-reactive protein concentration is associated with a higher risk of mortality in a rural Korean population",
abstract = "Objectives: C-reactive protein (CRP), an inflammatory biomarker, has been widely used as a preclinical marker predictive of morbidity and mortality. Although many studies have reported a positive association between CRP and mortality, uncertainty still remains about this association in various populations, especially in rural Korea. Methods: A total of 23 233 middle-aged participants (8862 men and 14 371 women) who were free from cardiovascular disease, cancer, and acute inflammation (defined by a CRP level =10 mg/L) were drawn from 11 rural communities in Korea between 2005 and 2011. Blood CRP concentration was analyzed as a categorical variable (low: 0.0-0.9 mg/L; intermediate: 1.0-3.0 mg/L; high: 3.1-9.9 mg/L) as well as a continuous variable. Each participant's vital status through December 2013 was confirmed by death statistics from the National Statistical Office. Cox proportional hazard models were used to assess the independent association between CRP and mortality after adjusting for other risk factors. Results: The total quantity of observed person-years was 57 975 for men and 95 146 for women, and the number of deaths was 649 among men and 367 among women. Compared to the low-CRP group, the adjusted hazard ratio for all-cause mortality of the intermediate group was 1.17 (95{\%} confidence interval [CI], 0.98 to 1.40) for men and 1.27 (95{\%} CI, 1.01 to 1.61) for women, and the corresponding values for the high-CRP group were 1.98 (95{\%} CI, 1.61 to 2.42) for men and 1.41 (95{\%} CI, 1.03 to 1.95) for women. Similar trends were found for CRP evaluated as a continuous variable and for cardiovascular mortality. Conclusions: Higher CRP concentrations were associated with higher mortality in a rural Korean population, and this association was more prominent in men than in women.",
author = "Lee, {Jung Hyun} and Hyungseon Yeom and HyeonChang Kim and Il Suh and Kim, {Mi Kyung} and Shin, {Min Ho} and Shin, {Dong Hoon} and Sangbaek Koh and Songvogue Ahn and Lee, {Tae Yong} and Ryu, {So Yeon} and Song, {Jae Sok} and Choe, {Hong Soon} and Lee, {Young Hoon} and Choi, {Bo Youl}",
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Lee, JH, Yeom, H, Kim, H, Suh, I, Kim, MK, Shin, MH, Shin, DH, Koh, S, Ahn, S, Lee, TY, Ryu, SY, Song, JS, Choe, HS, Lee, YH & Choi, BY 2016, 'C-reactive protein concentration is associated with a higher risk of mortality in a rural Korean population', Journal of Preventive Medicine and Public Health, vol. 49, no. 5, pp. 275-287. https://doi.org/10.3961/jpmph.16.025

C-reactive protein concentration is associated with a higher risk of mortality in a rural Korean population. / Lee, Jung Hyun; Yeom, Hyungseon; Kim, HyeonChang; Suh, Il; Kim, Mi Kyung; Shin, Min Ho; Shin, Dong Hoon; Koh, Sangbaek; Ahn, Songvogue; Lee, Tae Yong; Ryu, So Yeon; Song, Jae Sok; Choe, Hong Soon; Lee, Young Hoon; Choi, Bo Youl.

In: Journal of Preventive Medicine and Public Health, Vol. 49, No. 5, 01.09.2016, p. 275-287.

Research output: Contribution to journalArticle

TY - JOUR

T1 - C-reactive protein concentration is associated with a higher risk of mortality in a rural Korean population

AU - Lee, Jung Hyun

AU - Yeom, Hyungseon

AU - Kim, HyeonChang

AU - Suh, Il

AU - Kim, Mi Kyung

AU - Shin, Min Ho

AU - Shin, Dong Hoon

AU - Koh, Sangbaek

AU - Ahn, Songvogue

AU - Lee, Tae Yong

AU - Ryu, So Yeon

AU - Song, Jae Sok

AU - Choe, Hong Soon

AU - Lee, Young Hoon

AU - Choi, Bo Youl

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Objectives: C-reactive protein (CRP), an inflammatory biomarker, has been widely used as a preclinical marker predictive of morbidity and mortality. Although many studies have reported a positive association between CRP and mortality, uncertainty still remains about this association in various populations, especially in rural Korea. Methods: A total of 23 233 middle-aged participants (8862 men and 14 371 women) who were free from cardiovascular disease, cancer, and acute inflammation (defined by a CRP level =10 mg/L) were drawn from 11 rural communities in Korea between 2005 and 2011. Blood CRP concentration was analyzed as a categorical variable (low: 0.0-0.9 mg/L; intermediate: 1.0-3.0 mg/L; high: 3.1-9.9 mg/L) as well as a continuous variable. Each participant's vital status through December 2013 was confirmed by death statistics from the National Statistical Office. Cox proportional hazard models were used to assess the independent association between CRP and mortality after adjusting for other risk factors. Results: The total quantity of observed person-years was 57 975 for men and 95 146 for women, and the number of deaths was 649 among men and 367 among women. Compared to the low-CRP group, the adjusted hazard ratio for all-cause mortality of the intermediate group was 1.17 (95% confidence interval [CI], 0.98 to 1.40) for men and 1.27 (95% CI, 1.01 to 1.61) for women, and the corresponding values for the high-CRP group were 1.98 (95% CI, 1.61 to 2.42) for men and 1.41 (95% CI, 1.03 to 1.95) for women. Similar trends were found for CRP evaluated as a continuous variable and for cardiovascular mortality. Conclusions: Higher CRP concentrations were associated with higher mortality in a rural Korean population, and this association was more prominent in men than in women.

AB - Objectives: C-reactive protein (CRP), an inflammatory biomarker, has been widely used as a preclinical marker predictive of morbidity and mortality. Although many studies have reported a positive association between CRP and mortality, uncertainty still remains about this association in various populations, especially in rural Korea. Methods: A total of 23 233 middle-aged participants (8862 men and 14 371 women) who were free from cardiovascular disease, cancer, and acute inflammation (defined by a CRP level =10 mg/L) were drawn from 11 rural communities in Korea between 2005 and 2011. Blood CRP concentration was analyzed as a categorical variable (low: 0.0-0.9 mg/L; intermediate: 1.0-3.0 mg/L; high: 3.1-9.9 mg/L) as well as a continuous variable. Each participant's vital status through December 2013 was confirmed by death statistics from the National Statistical Office. Cox proportional hazard models were used to assess the independent association between CRP and mortality after adjusting for other risk factors. Results: The total quantity of observed person-years was 57 975 for men and 95 146 for women, and the number of deaths was 649 among men and 367 among women. Compared to the low-CRP group, the adjusted hazard ratio for all-cause mortality of the intermediate group was 1.17 (95% confidence interval [CI], 0.98 to 1.40) for men and 1.27 (95% CI, 1.01 to 1.61) for women, and the corresponding values for the high-CRP group were 1.98 (95% CI, 1.61 to 2.42) for men and 1.41 (95% CI, 1.03 to 1.95) for women. Similar trends were found for CRP evaluated as a continuous variable and for cardiovascular mortality. Conclusions: Higher CRP concentrations were associated with higher mortality in a rural Korean population, and this association was more prominent in men than in women.

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JO - Journal of Preventive Medicine and Public Health

JF - Journal of Preventive Medicine and Public Health

SN - 1975-8375

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