Ca-alginate microspheres encapsulated in chitosan beads

S. B. Park, H. W. Kang, Seungjoo Haam, H. Y. Park, W. S. Kim

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Chitosan beads (CBs) incorporating Ca-alginate microspheres (CAMs), containing a drug, were prepared as an oral sustained delivery system. Stable and monodisperse Ca-alginate microspheres loaded with drug were obtained by a membrane emulsification method. The Ca-alginate microspheres were encapsulated in chitosan beads by the ionotropic gelation method with a polyelectrolyte complex reaction between two oppositely charged polyions. The surface and internal characteristics of the beads were improved by ionic cross-linking in tripolyphosphate (TPP) solution adjusted to pH 5.0. The release experiments were performed using lidocaine·HCl (cationic drug) and sodium salicylate (anionic drug as model drugs. Initial release of drugs depended on the degree of swelling. Ca-alginate microspheres encapsulated in chitosan beads were superior to both drug-loaded CBs and CAMs beads for sustained release because they had a three-layer composition; a calcium alginate core bounded by an inter-phasic chitosan-alginate membrane, which itself was surrounded by a layer of chitosan-TPP.

Original languageEnglish
Pages (from-to)485-497
Number of pages13
JournalJournal of Microencapsulation
Volume21
Issue number5
DOIs
Publication statusPublished - 2004 Aug 1

Fingerprint

Alginate
Chitosan
Microspheres
beads
drugs
Pharmaceutical Preparations
Ionotropic gelation
sodium salicylates
Sodium Salicylate
membranes
Membranes
Emulsification
gelation
alginic acid
Polyelectrolytes
swelling
Swelling
calcium
Calcium
delivery

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry

Cite this

Park, S. B. ; Kang, H. W. ; Haam, Seungjoo ; Park, H. Y. ; Kim, W. S. / Ca-alginate microspheres encapsulated in chitosan beads. In: Journal of Microencapsulation. 2004 ; Vol. 21, No. 5. pp. 485-497.
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Ca-alginate microspheres encapsulated in chitosan beads. / Park, S. B.; Kang, H. W.; Haam, Seungjoo; Park, H. Y.; Kim, W. S.

In: Journal of Microencapsulation, Vol. 21, No. 5, 01.08.2004, p. 485-497.

Research output: Contribution to journalArticle

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