Caenorhabditis elegans dna-2 is involved in DNA repair and is essential for germ-line development

Myon Hee Lee, Sung Min Han, Ji Won Han, Yun Mi Kim, Joohong Ahnn, Hyeon Sook Koo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Caenorhabditis elegans germ cell proliferation and development were severely damaged in second generation dna-2 homozygotes. Even in the first generation, a much higher incidence of aberrant chromosomes in oocytes and resultantly higher embryonic lethality were found vs. wild type, when DNA breaks were induced by γ-rays or camptothecin. The deficiency of dna-2 in combination with RNA interference on mre-11 gene expression synergistically aggravated germ-line development, especially oocyte formation. These results suggest that C. elegans Dna-2 is involved in a DNA repair pathway paralleling homologous recombination or non-homologous end joining with mre-11 participation.

Original languageEnglish
Pages (from-to)250-256
Number of pages7
JournalFEBS Letters
Volume555
Issue number2
DOIs
Publication statusPublished - 2003 Dec 4

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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