Abstract
Objectives: To determine the usefulness of the apparent diffusion coefficient (ADC) in predicting response to uterine artery embolization (UAE) for symptomatic adenomyosis. Methods: A prospective study was performed on 25 patients who underwent diffusion-weighted (DW) magnetic resonance imaging (MRI) before UAE between June 2011 and December 2012. All patients underwent 3-month follow-up MRI after UAE using non-spherical polyvinyl alcohol (PVA) particles ranging from 150 to 500 μm. Quantitative measurement of the ADC was performed for each adenomyosis. Complete response and incomplete response were defined as ≥90 % or <90 %, respectively, of the non-perfusion area with adenomyosis at the follow-up MRI. The ADC values were compared between patients who achieved complete or incomplete response which was assessed according to the MRI findings after UAE. Results: Nineteen patients showed complete response, and six showed incomplete response. The ADC value ranged from 0.842 to 1.346 × 10-3 mm2/s (mean 1.075 ± 0.117). The mean ADC was 1.043 ± 0.237 in the complete response group and 1.176 ± 0.429 in the incomplete response group (0.012). Using a threshold of <1.147 × 10-3 mm2/s, the sensitivity and specificity of the ADC to predict success after UAE were 83.3 % and 84.2 %. Conclusion: The ADC of adenomyosis may potentially predict a successful response to UAE for adenomyosis. Key Points: • Pre-procedural MRI might help clinicians predict response of UAE in adenomyosis • ADC might help predict UAE outcomes in adenomyosis • MR predictors might be used to counsel patients with symptomatic adenomyosis
| Original language | English |
|---|---|
| Pages (from-to) | 1303-1309 |
| Number of pages | 7 |
| Journal | European Radiology |
| Volume | 25 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2015 May 1 |
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All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
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Can measurement of apparent diffusion coefficient before treatment predict the response to uterine artery embolization for adenomyosis? / Park, Yaewon; Kim, ManDeuk; Jung, Dae Chul; Lee, Shin Jae; Kim, Gyoungmin; Park, Sung Il; Won, Jong Yun; Lee, Do Yun.
In: European Radiology, Vol. 25, No. 5, 01.05.2015, p. 1303-1309.Research output: Contribution to journal › Article
TY - JOUR
T1 - Can measurement of apparent diffusion coefficient before treatment predict the response to uterine artery embolization for adenomyosis?
AU - Park, Yaewon
AU - Kim, ManDeuk
AU - Jung, Dae Chul
AU - Lee, Shin Jae
AU - Kim, Gyoungmin
AU - Park, Sung Il
AU - Won, Jong Yun
AU - Lee, Do Yun
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Objectives: To determine the usefulness of the apparent diffusion coefficient (ADC) in predicting response to uterine artery embolization (UAE) for symptomatic adenomyosis. Methods: A prospective study was performed on 25 patients who underwent diffusion-weighted (DW) magnetic resonance imaging (MRI) before UAE between June 2011 and December 2012. All patients underwent 3-month follow-up MRI after UAE using non-spherical polyvinyl alcohol (PVA) particles ranging from 150 to 500 μm. Quantitative measurement of the ADC was performed for each adenomyosis. Complete response and incomplete response were defined as ≥90 % or <90 %, respectively, of the non-perfusion area with adenomyosis at the follow-up MRI. The ADC values were compared between patients who achieved complete or incomplete response which was assessed according to the MRI findings after UAE. Results: Nineteen patients showed complete response, and six showed incomplete response. The ADC value ranged from 0.842 to 1.346 × 10-3 mm2/s (mean 1.075 ± 0.117). The mean ADC was 1.043 ± 0.237 in the complete response group and 1.176 ± 0.429 in the incomplete response group (0.012). Using a threshold of <1.147 × 10-3 mm2/s, the sensitivity and specificity of the ADC to predict success after UAE were 83.3 % and 84.2 %. Conclusion: The ADC of adenomyosis may potentially predict a successful response to UAE for adenomyosis. Key Points: • Pre-procedural MRI might help clinicians predict response of UAE in adenomyosis • ADC might help predict UAE outcomes in adenomyosis • MR predictors might be used to counsel patients with symptomatic adenomyosis
AB - Objectives: To determine the usefulness of the apparent diffusion coefficient (ADC) in predicting response to uterine artery embolization (UAE) for symptomatic adenomyosis. Methods: A prospective study was performed on 25 patients who underwent diffusion-weighted (DW) magnetic resonance imaging (MRI) before UAE between June 2011 and December 2012. All patients underwent 3-month follow-up MRI after UAE using non-spherical polyvinyl alcohol (PVA) particles ranging from 150 to 500 μm. Quantitative measurement of the ADC was performed for each adenomyosis. Complete response and incomplete response were defined as ≥90 % or <90 %, respectively, of the non-perfusion area with adenomyosis at the follow-up MRI. The ADC values were compared between patients who achieved complete or incomplete response which was assessed according to the MRI findings after UAE. Results: Nineteen patients showed complete response, and six showed incomplete response. The ADC value ranged from 0.842 to 1.346 × 10-3 mm2/s (mean 1.075 ± 0.117). The mean ADC was 1.043 ± 0.237 in the complete response group and 1.176 ± 0.429 in the incomplete response group (0.012). Using a threshold of <1.147 × 10-3 mm2/s, the sensitivity and specificity of the ADC to predict success after UAE were 83.3 % and 84.2 %. Conclusion: The ADC of adenomyosis may potentially predict a successful response to UAE for adenomyosis. Key Points: • Pre-procedural MRI might help clinicians predict response of UAE in adenomyosis • ADC might help predict UAE outcomes in adenomyosis • MR predictors might be used to counsel patients with symptomatic adenomyosis
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U2 - 10.1007/s00330-014-3504-3
DO - 10.1007/s00330-014-3504-3
M3 - Article
VL - 25
SP - 1303
EP - 1309
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 5
ER -