Cancer Association Study of Aminoacyl-tRNA Synthetase Signaling Network in Glioblastoma

Yong Wan Kim, Chang Hyuk Kwon, Juinn Lin Liu, Se Hoon Kim, Sunghoon Kim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Aminoacyl-tRNA synthetases (ARSs) and ARS-interacting multifunctional proteins (AIMPs) exhibit remarkable functional versatility beyond their catalytic activities in protein synthesis. Their non-canonical functions have been pathologically linked to cancers. Here we described our integrative genome-wide analysis of ARSs to show cancer-associated activities in glioblastoma multiforme (GBM), the most aggressive malignant primary brain tumor. We first selected 23 ARS/AIMPs (together referred to as ARSN), 124 cancer-associated druggable target genes (DTGs) and 404 protein-protein interactors (PPIs) of ARSs using NCI's cancer gene index. 254 GBM affymetrix microarray data in The Cancer Genome Atlas (TCGA) were used to identify the probe sets whose expression were most strongly correlated with survival (Kaplan-Meier plots versus survival times, log-rank t-test <0.05). The analysis identified 122 probe sets as survival signatures, including 5 of ARSN (VARS, QARS, CARS, NARS, FARS), and 115 of DTGs and PPIs (PARD3, RXRB, ATP5C1, HSP90AA1, CD44, THRA, TRAF2, KRT10, MED12, etc). Of note, 61 survival-related probes were differentially expressed in three different prognosis subgroups in GBM patients and showed correlation with established prognosis markers such as age and phenotypic molecular signatures. CARS and FARS also showed significantly higher association with different molecular networks in GBM patients. Taken together, our findings demonstrate evidence for an ARSN biology-dominant contribution in the biology of GBM.

Original languageEnglish
Article numbere40960
JournalPloS one
Volume7
Issue number8
DOIs
Publication statusPublished - 2012 Aug 31

Fingerprint

aminoacyl tRNA ligases
Amino Acyl-tRNA Synthetases
Glioblastoma
neoplasms
Genes
Neoplasms
Proteins
proteins
Survival
prognosis
TNF Receptor-Associated Factor 2
Biological Sciences
Genome
genome
genes
Atlases
catalytic activity
Neoplasm Genes
Microarrays
Brain Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Kim, Yong Wan ; Kwon, Chang Hyuk ; Liu, Juinn Lin ; Kim, Se Hoon ; Kim, Sunghoon. / Cancer Association Study of Aminoacyl-tRNA Synthetase Signaling Network in Glioblastoma. In: PloS one. 2012 ; Vol. 7, No. 8.
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Cancer Association Study of Aminoacyl-tRNA Synthetase Signaling Network in Glioblastoma. / Kim, Yong Wan; Kwon, Chang Hyuk; Liu, Juinn Lin; Kim, Se Hoon; Kim, Sunghoon.

In: PloS one, Vol. 7, No. 8, e40960, 31.08.2012.

Research output: Contribution to journalArticle

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