Cancer Cell Detection on the Surface of Top-Gated Monolayer Graphene via Raman Spectroscopy

Sitansu Sekhar Nanda, Sandeep Kaushal, Yong Shin, Kyusik Yun, Seong Soo A. An, K. P.S.S. Hembram, Georgia C. Papaefthymiou, Dong Kee Yi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


A label-free biosensor is described based on the Raman spectroscopic signatures of monolayer graphene, which are modified in the compartment of cancer cells because of electron-phonon coupling in monolayer graphene. Specifically, the Raman spectra of electrostatically gated monolayer graphene on SiO2/Si substrates, in the voltage range from 0 to 5 V, were studied in the absence and the presence of cancer cells. Density functional theory simulations afforded a correlation between cancer cells and the observed Raman spectra, through the regulation of the intensities of the G and 2D Raman vibrational modes with applied voltage. The C-H and N-H bonds of phenylalanine enabled the detection of this biosensing activity. Significantly, this detection can be carried out even in the absence of cancer cell-culturing steps.

Original languageEnglish
Pages (from-to)1493-1498
Number of pages6
JournalACS Applied Bio Materials
Issue number2
Publication statusPublished - 2021 Feb 15

Bibliographical note

Funding Information:
This work was supported by the Korean National Research Foundation (NRF-NRF, 2018R1A2B6007786).

Publisher Copyright:
© 2021 American Chemical Society.

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomaterials
  • Biomedical Engineering
  • Biochemistry, medical


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