Cancer Cells Microsurgery via Asymmetric Bent Surface Au/Ag/Ni Microrobotic Scalpels through a Transversal Rotating Magnetic Field

Jan Vyskočil, Carmen C. Mayorga-Martinez, Eva Jablonská, Filip Novotný, Tomáš Ruml, Martin Pumera

Research output: Contribution to journalArticle

Abstract

The actuation of micro/nanomachines by means of a magnetic field is a promising fuel-free way to transport cargo in microscale dimensions. This type of movement has been extensively studied for a variety of micro/nanomachine designs, and a special magnetic field configuration results in a near-surface walking. We developed "walking"micromachines which transversally move in a magnetic field, and we used them as microrobotic scalpels to enter and exit an individual cancer cell and cut a small cellular fragment. In these microscalpels, the center of mass lies approximately in the middle of their length. The microrobotic scalpels show good propulsion efficiency and high step-out frequencies of the magnetic field. Au/Ag/Ni microrobotic scalpels controlled by a transversal rotating magnetic field can enter the cytoplasm of cancer cells and also are able to remove a piece of the cytosol while leaving the cytoplasmic membrane intact in a microsurgery-like manner. We believe that this concept can be further developed for potential biological or medical applications.

Original languageEnglish
Pages (from-to)8247-8256
Number of pages10
JournalACS Nano
Volume14
Issue number7
DOIs
Publication statusPublished - 2020 Jul 28

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'Cancer Cells Microsurgery via Asymmetric Bent Surface Au/Ag/Ni Microrobotic Scalpels through a Transversal Rotating Magnetic Field'. Together they form a unique fingerprint.

  • Cite this