Cancer classification with incremental gene selection based on DNA microarray data

Jin Hyuk Hong, Sung Bae Cho

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Gene selection is an important issue for cancer classification based on gene expression profiles. Filter and wrapper approaches are used widely for gene selection, where the former is hard to measure the relationship between genes and the latter requires lots of computation. We present a novel method, called gene boosting, to select relevant gene subsets by integrating filter and wrapper approaches. It repeatedly selects a set of top-ranked informative genes by a filtering algorithm with respect to a temporal training dataset constructed according to the classification result for the original training dataset. Empirical results on three microarray benchmark datasets have shown that the proposed method is effective and efficient in finding a relevant and concise gene subset. Competitive performance was achieved with fewer genes in a reasonable time. This also led to the identification of some genes selected frequently as useful features.

Original languageEnglish
Title of host publication2008 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '08
Pages70-74
Number of pages5
DOIs
Publication statusPublished - 2008 Dec 1
Event2008 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '08 - Sun Valley, ID, United States
Duration: 2008 Sep 152008 Sep 17

Publication series

Name2008 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '08

Other

Other2008 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '08
CountryUnited States
CitySun Valley, ID
Period08/9/1508/9/17

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All Science Journal Classification (ASJC) codes

  • Artificial Intelligence
  • Computational Theory and Mathematics
  • Biomedical Engineering
  • Health Informatics

Cite this

Hong, J. H., & Cho, S. B. (2008). Cancer classification with incremental gene selection based on DNA microarray data. In 2008 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '08 (pp. 70-74). [4675761] (2008 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '08). https://doi.org/10.1109/CIBCB.2008.4675761