Cancer diagnosis by terahertz molecular imaging technique

Seung Jae Oh, Yong Min Huh, Jin Suck Suh, Jihye Choi, Seungjoo Haam, Joo Hiuk Son

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


We obtained the diagnostic images of cancerous tumors by employing the THz molecular imaging (TMI) technique which measured the THz response change by surface plasmon resonance induced on the surface of nanoparticles with a irradiation of near-infrared (NIR) beam. To demonstrate the principle of the TMI technique, THz images of tissues with nanoprobes were observed and compared with THz only images. The sensitivity of TMI was further enhanced by adopting a THz differential measurement technique, which was realized by modulating the NIR beams. By employing this differential TMI technique, the diagnostic images of cancerous tumors were obtained ex vivo and in vivo in the preclinical stage. These images indicated the feasibility of applying the differential TMI technique in the clinical stage.

Original languageEnglish
Pages (from-to)74-81
Number of pages8
JournalJournal of Infrared, Millimeter, and Terahertz Waves
Issue number1
Publication statusPublished - 2012 Jan

Bibliographical note

Funding Information:
Acknowledgment This study was supported by a grant from the Korean Health Technology R&D Project of the Ministry for Health, Welfare & Family Affairs, Republic of Korea (A101954); a National Research Foundation of Korea (NRF) grants funded by the Ministry of Education Science & Technology, Republic of Korea (20100020647, 20100001979, 20100015989, 20100011934, 20090054519); Business for cooperative R&D between industry, academy, and research institute funded Korea small and medium business administration in 2010 (000428380110).

All Science Journal Classification (ASJC) codes

  • Radiation
  • Instrumentation
  • Condensed Matter Physics
  • Electrical and Electronic Engineering


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