We obtained the diagnostic images of cancerous tumors by employing the THz molecular imaging (TMI) technique which measured the THz response change by surface plasmon resonance induced on the surface of nanoparticles with a irradiation of near-infrared (NIR) beam. To demonstrate the principle of the TMI technique, THz images of tissues with nanoprobes were observed and compared with THz only images. The sensitivity of TMI was further enhanced by adopting a THz differential measurement technique, which was realized by modulating the NIR beams. By employing this differential TMI technique, the diagnostic images of cancerous tumors were obtained ex vivo and in vivo in the preclinical stage. These images indicated the feasibility of applying the differential TMI technique in the clinical stage.
|Number of pages||8|
|Journal||Journal of Infrared, Millimeter, and Terahertz Waves|
|Publication status||Published - 2012 Jan|
Bibliographical noteFunding Information:
Acknowledgment This study was supported by a grant from the Korean Health Technology R&D Project of the Ministry for Health, Welfare & Family Affairs, Republic of Korea (A101954); a National Research Foundation of Korea (NRF) grants funded by the Ministry of Education Science & Technology, Republic of Korea (20100020647, 20100001979, 20100015989, 20100011934, 20090054519); Business for cooperative R&D between industry, academy, and research institute funded Korea small and medium business administration in 2010 (000428380110).
All Science Journal Classification (ASJC) codes
- Condensed Matter Physics
- Electrical and Electronic Engineering