Cancer in Korean patients with end-stage renal disease: A 7-year follow-up

Kyung Don Yoo, Jung Pyo Lee, Su Mi Lee, Jae Yoon Park, Hajeong Lee, Dong Ki Kim, Shin-Wook Kang, Chul Woo Yang, Yong Lim Kim, Chun Soo Lim, Kwon Wook Joo, Yon Su Kim

Research output: Contribution to journalArticle

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Abstract

Background The effectiveness of dialysis on the incidence of cancer in patients with end-stage renal disease (ESRD) remains to be clarified. In this study, we evaluated the incidence rate and type of cancer among patients with ESRD, compared to the general population, through a prospective 7-year follow-up. We also calculated the cumulative incidence rate of cancer associated with ESRD, with stratification to control for the competing risk of death. Methods This prospective observational cohort study was conducted using data from a nationwide study on patients with ESRD in Korea. A total of 5,235 patients, 18 years old, with ESRD were identified from the national registry as being treated by dialysis between August 2008 and December 2014. The standardized incidence ratio (SIR) and cumulative incidence rate of specific cancers were evaluated and compared to the general population. Results A total of 5,235 participants were included. During the 7 year observation period, 116 (2.2%) participants had been diagnosed as cancer. The SIR of overall cancer was 0.94 [95% confidence interval (CI), 0.72–1.19] and was comparable to the rate for the general population. Although the digestive organs were the most frequent site of a primary site cancer (N = 39, 33.6%), the SIR was highest for urinary tract cancer [4.7, 95% CI, 2.42–8.19]. The five year standardized cumulative incidence of cancer was higher for females than for males, and for non-diabetic compared to diabetic causes of ESRD. We estimated that the five year standardized cumulative incidence was highest [8.4, 95% CI, 5.07–13.75] in patients with ESRD, caused by glomerulonephritis. Conclusion A screening program should be necessary for urinary tract cancer in Korean patients with ESRD. Cancer screening programs for patients with ESRD in Korea should be emphasized on female patients and patients with non-diabetic ESRD.

Original languageEnglish
Article numbere0178649
JournalPLoS One
Volume12
Issue number7
DOIs
Publication statusPublished - 2017 Jul 1

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kidney diseases
Chronic Kidney Failure
incidence
neoplasms
Incidence
Neoplasms
Urologic Neoplasms
Dialysis
confidence interval
Confidence Intervals
Korea
urinary tract
dialysis
Screening
Korean Peninsula
Population
screening
glomerulonephritis
national surveys
Glomerulonephritis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Yoo, K. D., Lee, J. P., Lee, S. M., Park, J. Y., Lee, H., Kim, D. K., ... Kim, Y. S. (2017). Cancer in Korean patients with end-stage renal disease: A 7-year follow-up. PLoS One, 12(7), [e0178649]. https://doi.org/10.1371/journal.pone.0178649
Yoo, Kyung Don ; Lee, Jung Pyo ; Lee, Su Mi ; Park, Jae Yoon ; Lee, Hajeong ; Kim, Dong Ki ; Kang, Shin-Wook ; Yang, Chul Woo ; Kim, Yong Lim ; Lim, Chun Soo ; Joo, Kwon Wook ; Kim, Yon Su. / Cancer in Korean patients with end-stage renal disease : A 7-year follow-up. In: PLoS One. 2017 ; Vol. 12, No. 7.
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title = "Cancer in Korean patients with end-stage renal disease: A 7-year follow-up",
abstract = "Background The effectiveness of dialysis on the incidence of cancer in patients with end-stage renal disease (ESRD) remains to be clarified. In this study, we evaluated the incidence rate and type of cancer among patients with ESRD, compared to the general population, through a prospective 7-year follow-up. We also calculated the cumulative incidence rate of cancer associated with ESRD, with stratification to control for the competing risk of death. Methods This prospective observational cohort study was conducted using data from a nationwide study on patients with ESRD in Korea. A total of 5,235 patients, 18 years old, with ESRD were identified from the national registry as being treated by dialysis between August 2008 and December 2014. The standardized incidence ratio (SIR) and cumulative incidence rate of specific cancers were evaluated and compared to the general population. Results A total of 5,235 participants were included. During the 7 year observation period, 116 (2.2{\%}) participants had been diagnosed as cancer. The SIR of overall cancer was 0.94 [95{\%} confidence interval (CI), 0.72–1.19] and was comparable to the rate for the general population. Although the digestive organs were the most frequent site of a primary site cancer (N = 39, 33.6{\%}), the SIR was highest for urinary tract cancer [4.7, 95{\%} CI, 2.42–8.19]. The five year standardized cumulative incidence of cancer was higher for females than for males, and for non-diabetic compared to diabetic causes of ESRD. We estimated that the five year standardized cumulative incidence was highest [8.4, 95{\%} CI, 5.07–13.75] in patients with ESRD, caused by glomerulonephritis. Conclusion A screening program should be necessary for urinary tract cancer in Korean patients with ESRD. Cancer screening programs for patients with ESRD in Korea should be emphasized on female patients and patients with non-diabetic ESRD.",
author = "Yoo, {Kyung Don} and Lee, {Jung Pyo} and Lee, {Su Mi} and Park, {Jae Yoon} and Hajeong Lee and Kim, {Dong Ki} and Shin-Wook Kang and Yang, {Chul Woo} and Kim, {Yong Lim} and Lim, {Chun Soo} and Joo, {Kwon Wook} and Kim, {Yon Su}",
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Yoo, KD, Lee, JP, Lee, SM, Park, JY, Lee, H, Kim, DK, Kang, S-W, Yang, CW, Kim, YL, Lim, CS, Joo, KW & Kim, YS 2017, 'Cancer in Korean patients with end-stage renal disease: A 7-year follow-up', PLoS One, vol. 12, no. 7, e0178649. https://doi.org/10.1371/journal.pone.0178649

Cancer in Korean patients with end-stage renal disease : A 7-year follow-up. / Yoo, Kyung Don; Lee, Jung Pyo; Lee, Su Mi; Park, Jae Yoon; Lee, Hajeong; Kim, Dong Ki; Kang, Shin-Wook; Yang, Chul Woo; Kim, Yong Lim; Lim, Chun Soo; Joo, Kwon Wook; Kim, Yon Su.

In: PLoS One, Vol. 12, No. 7, e0178649, 01.07.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cancer in Korean patients with end-stage renal disease

T2 - A 7-year follow-up

AU - Yoo, Kyung Don

AU - Lee, Jung Pyo

AU - Lee, Su Mi

AU - Park, Jae Yoon

AU - Lee, Hajeong

AU - Kim, Dong Ki

AU - Kang, Shin-Wook

AU - Yang, Chul Woo

AU - Kim, Yong Lim

AU - Lim, Chun Soo

AU - Joo, Kwon Wook

AU - Kim, Yon Su

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background The effectiveness of dialysis on the incidence of cancer in patients with end-stage renal disease (ESRD) remains to be clarified. In this study, we evaluated the incidence rate and type of cancer among patients with ESRD, compared to the general population, through a prospective 7-year follow-up. We also calculated the cumulative incidence rate of cancer associated with ESRD, with stratification to control for the competing risk of death. Methods This prospective observational cohort study was conducted using data from a nationwide study on patients with ESRD in Korea. A total of 5,235 patients, 18 years old, with ESRD were identified from the national registry as being treated by dialysis between August 2008 and December 2014. The standardized incidence ratio (SIR) and cumulative incidence rate of specific cancers were evaluated and compared to the general population. Results A total of 5,235 participants were included. During the 7 year observation period, 116 (2.2%) participants had been diagnosed as cancer. The SIR of overall cancer was 0.94 [95% confidence interval (CI), 0.72–1.19] and was comparable to the rate for the general population. Although the digestive organs were the most frequent site of a primary site cancer (N = 39, 33.6%), the SIR was highest for urinary tract cancer [4.7, 95% CI, 2.42–8.19]. The five year standardized cumulative incidence of cancer was higher for females than for males, and for non-diabetic compared to diabetic causes of ESRD. We estimated that the five year standardized cumulative incidence was highest [8.4, 95% CI, 5.07–13.75] in patients with ESRD, caused by glomerulonephritis. Conclusion A screening program should be necessary for urinary tract cancer in Korean patients with ESRD. Cancer screening programs for patients with ESRD in Korea should be emphasized on female patients and patients with non-diabetic ESRD.

AB - Background The effectiveness of dialysis on the incidence of cancer in patients with end-stage renal disease (ESRD) remains to be clarified. In this study, we evaluated the incidence rate and type of cancer among patients with ESRD, compared to the general population, through a prospective 7-year follow-up. We also calculated the cumulative incidence rate of cancer associated with ESRD, with stratification to control for the competing risk of death. Methods This prospective observational cohort study was conducted using data from a nationwide study on patients with ESRD in Korea. A total of 5,235 patients, 18 years old, with ESRD were identified from the national registry as being treated by dialysis between August 2008 and December 2014. The standardized incidence ratio (SIR) and cumulative incidence rate of specific cancers were evaluated and compared to the general population. Results A total of 5,235 participants were included. During the 7 year observation period, 116 (2.2%) participants had been diagnosed as cancer. The SIR of overall cancer was 0.94 [95% confidence interval (CI), 0.72–1.19] and was comparable to the rate for the general population. Although the digestive organs were the most frequent site of a primary site cancer (N = 39, 33.6%), the SIR was highest for urinary tract cancer [4.7, 95% CI, 2.42–8.19]. The five year standardized cumulative incidence of cancer was higher for females than for males, and for non-diabetic compared to diabetic causes of ESRD. We estimated that the five year standardized cumulative incidence was highest [8.4, 95% CI, 5.07–13.75] in patients with ESRD, caused by glomerulonephritis. Conclusion A screening program should be necessary for urinary tract cancer in Korean patients with ESRD. Cancer screening programs for patients with ESRD in Korea should be emphasized on female patients and patients with non-diabetic ESRD.

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Yoo KD, Lee JP, Lee SM, Park JY, Lee H, Kim DK et al. Cancer in Korean patients with end-stage renal disease: A 7-year follow-up. PLoS One. 2017 Jul 1;12(7). e0178649. https://doi.org/10.1371/journal.pone.0178649