Candida guilliermondii, an opportunistic fungal pathogen with decreased susceptibility to fluconazole

Geographic and temporal trends from the ARTEMIS DISK antifungal surveillance program

M. A. Pfaller, D. J. Diekema, M. Mendez, C. Kibbler, P. Erzsebet, S. C. Chang, D. L. Gibbs, V. A. Newell, Jorge Finquelievich, Nora Tiraboschi, David Ellis, Dominique Frameree, Annemarie van den Abeele, Jean Marc Senterre, Arnaldo Colombo, Robert Rennie, Steve Sanche, Bijie Hu, Yingchun Xu, Yingyuan Zhang & 92 others Nan Shan Zhong, Pilar Rivas, Angela Restrepo, Catalina Bedout, Ricardo Vega, Matilde Mendez, Nada Mallatova, Stanislava Dobiasova, Julio Ayabaca, Jeannete Zurita, M. Mallie, E. Candolfi, W. Fegeler, A. Haase, G. Rodloff, W. Bar, V. Czaika, George Petrikos, Erzsébet Puskás, Ilona Doczi, Mestyan Gyula, Radka Nikolova, Uma Banerjee, Nathan Keller, Vivian Tullio, Gian Carlo Schito, Giacomo Fortina, Gian Piero Testore, Domenico D'Antonio, Giorgio Scalise, Pietro Martino, Graziana Manno, Kee Peng, Celia Alpuche, Jose Santos, Eduardo Rodriguez Noriega, Mussaret Zaidi, Jacques F.G.M. Meis, Egil Lingaas, Danuta Dzierzanowska, Waclaw Pawliszyn, Mariada Luz Martins, Luis Albuquerque, Laura Rosado, Rosa Velho, Jose Amorim, Vera N. Ilina, Olga I. Kretchikova, Galina A. Klyasova, Sophia M. Rozanova, Irina G. Multykh, Nikolay N. Klimko, Elena D. Agapova, Natalya V. Dmitrieva, Abdul Mohsen Al-Rasheed, Jan Trupl, Leon Langsadl, Alena Vaculikova, Hupkova Helena, Denise Roditi, Anwar Hoosen, H. H. Crewe-Brown, M. N. Janse van Rensburg, Adriano Duse, Kyungwon Lee, Mi Na Kim, A. del Palacio, Aurora Sanchez-Sousa, Jacques Bille, K. Muhlethaler, Jen Hsien Wang, Malai Vorachit, Deniz Gur, Volkan Korten, John Paul, Brian Jones, F. Kate Gould, Chris Kibbler, Nigel Weightman, Ian M. Gould, Ruth Ashbee, Rosemarie Barnes, Jose Vazquez, Ed Chan, Davise Larone, Ellen Jo Baron, Mahmoud A. Ghannoum, Mike Rinaldi, Kevin Hazen, Elyse Foraker, Heidi Reyes, Axel Santiago

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Although a rare cause of invasive candidiasis, Candida guilliermondii has been reported to exhibit decreased susceptibility to antifungal agents. Aside from case reports and small surveys, there is little information regarding the epidemiology and antifungal susceptibility profile of C. guilliermondii. We report geographic and temporal trends in the isolation and antifungal susceptibilities of 1,029 C. guilliermondii clinical isolates collected from 127 medical centers as part of the ARTEMIS DISK Antifungal Surveillance Program. In addition, we report the in vitro susceptibility of 132 bloodstream isolates of C. guilliermondii to caspofungin. C. guilliermondii represented 1.4% of the 75,761 isolates collected from 2001 to 2003 and was most common among isolates from Latin America (3.7% versus 0.6 to 1.1%). Decreased susceptibility to fluconazole was noted (75% susceptible; range, 68 to 77% across regions), and voriconazole was more active in vitro against C. guilliermondii than fluconazole (91% susceptible; range, 88 to 93% across regions). Fluconazole was least active against isolates from dermatology (58%) and surgical (69%) services and against isolates associated with skin and soft tissue infection (68%, compared to 85% susceptible for bloodstream isolates). There was no evidence of increasing azole resistance over time among C. guilliermondii isolates tested from 2001 to 2003. Of 132 bloodstream isolates of C. guilliermondii tested against caspofungin, most were inhibited by ≤2 μg/ml (96%; MIC 50/MIC90, 0.5/1.0 μg/ml). C. guilliermondii, a species that exhibits reduced susceptibility to fluconazole, is the sixth most frequently isolated Candida species from this large survey and may be an emerging pathogen in Latin America.

Original languageEnglish
Pages (from-to)3551-3556
Number of pages6
JournalJournal of Clinical Microbiology
Volume44
Issue number10
DOIs
Publication statusPublished - 2006 Oct 1

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Fluconazole
caspofungin
Candida
Latin America
Invasive Candidiasis
Azoles
Soft Tissue Infections
Antifungal Agents
Dermatology
Epidemiology
Skin
Surveys and Questionnaires
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

Cite this

Pfaller, M. A. ; Diekema, D. J. ; Mendez, M. ; Kibbler, C. ; Erzsebet, P. ; Chang, S. C. ; Gibbs, D. L. ; Newell, V. A. ; Finquelievich, Jorge ; Tiraboschi, Nora ; Ellis, David ; Frameree, Dominique ; van den Abeele, Annemarie ; Senterre, Jean Marc ; Colombo, Arnaldo ; Rennie, Robert ; Sanche, Steve ; Hu, Bijie ; Xu, Yingchun ; Zhang, Yingyuan ; Zhong, Nan Shan ; Rivas, Pilar ; Restrepo, Angela ; Bedout, Catalina ; Vega, Ricardo ; Mendez, Matilde ; Mallatova, Nada ; Dobiasova, Stanislava ; Ayabaca, Julio ; Zurita, Jeannete ; Mallie, M. ; Candolfi, E. ; Fegeler, W. ; Haase, A. ; Rodloff, G. ; Bar, W. ; Czaika, V. ; Petrikos, George ; Puskás, Erzsébet ; Doczi, Ilona ; Gyula, Mestyan ; Nikolova, Radka ; Banerjee, Uma ; Keller, Nathan ; Tullio, Vivian ; Carlo Schito, Gian ; Fortina, Giacomo ; Piero Testore, Gian ; D'Antonio, Domenico ; Scalise, Giorgio ; Martino, Pietro ; Manno, Graziana ; Peng, Kee ; Alpuche, Celia ; Santos, Jose ; Rodriguez Noriega, Eduardo ; Zaidi, Mussaret ; Meis, Jacques F.G.M. ; Lingaas, Egil ; Dzierzanowska, Danuta ; Pawliszyn, Waclaw ; Luz Martins, Mariada ; Albuquerque, Luis ; Rosado, Laura ; Velho, Rosa ; Amorim, Jose ; Ilina, Vera N. ; Kretchikova, Olga I. ; Klyasova, Galina A. ; Rozanova, Sophia M. ; Multykh, Irina G. ; Klimko, Nikolay N. ; Agapova, Elena D. ; Dmitrieva, Natalya V. ; Al-Rasheed, Abdul Mohsen ; Trupl, Jan ; Langsadl, Leon ; Vaculikova, Alena ; Helena, Hupkova ; Roditi, Denise ; Hoosen, Anwar ; Crewe-Brown, H. H. ; Janse van Rensburg, M. N. ; Duse, Adriano ; Lee, Kyungwon ; Kim, Mi Na ; del Palacio, A. ; Sanchez-Sousa, Aurora ; Bille, Jacques ; Muhlethaler, K. ; Wang, Jen Hsien ; Vorachit, Malai ; Gur, Deniz ; Korten, Volkan ; Paul, John ; Jones, Brian ; Kate Gould, F. ; Kibbler, Chris ; Weightman, Nigel ; Gould, Ian M. ; Ashbee, Ruth ; Barnes, Rosemarie ; Vazquez, Jose ; Chan, Ed ; Larone, Davise ; Jo Baron, Ellen ; Ghannoum, Mahmoud A. ; Rinaldi, Mike ; Hazen, Kevin ; Foraker, Elyse ; Reyes, Heidi ; Santiago, Axel. / Candida guilliermondii, an opportunistic fungal pathogen with decreased susceptibility to fluconazole : Geographic and temporal trends from the ARTEMIS DISK antifungal surveillance program. In: Journal of Clinical Microbiology. 2006 ; Vol. 44, No. 10. pp. 3551-3556.
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title = "Candida guilliermondii, an opportunistic fungal pathogen with decreased susceptibility to fluconazole: Geographic and temporal trends from the ARTEMIS DISK antifungal surveillance program",
abstract = "Although a rare cause of invasive candidiasis, Candida guilliermondii has been reported to exhibit decreased susceptibility to antifungal agents. Aside from case reports and small surveys, there is little information regarding the epidemiology and antifungal susceptibility profile of C. guilliermondii. We report geographic and temporal trends in the isolation and antifungal susceptibilities of 1,029 C. guilliermondii clinical isolates collected from 127 medical centers as part of the ARTEMIS DISK Antifungal Surveillance Program. In addition, we report the in vitro susceptibility of 132 bloodstream isolates of C. guilliermondii to caspofungin. C. guilliermondii represented 1.4{\%} of the 75,761 isolates collected from 2001 to 2003 and was most common among isolates from Latin America (3.7{\%} versus 0.6 to 1.1{\%}). Decreased susceptibility to fluconazole was noted (75{\%} susceptible; range, 68 to 77{\%} across regions), and voriconazole was more active in vitro against C. guilliermondii than fluconazole (91{\%} susceptible; range, 88 to 93{\%} across regions). Fluconazole was least active against isolates from dermatology (58{\%}) and surgical (69{\%}) services and against isolates associated with skin and soft tissue infection (68{\%}, compared to 85{\%} susceptible for bloodstream isolates). There was no evidence of increasing azole resistance over time among C. guilliermondii isolates tested from 2001 to 2003. Of 132 bloodstream isolates of C. guilliermondii tested against caspofungin, most were inhibited by ≤2 μg/ml (96{\%}; MIC 50/MIC90, 0.5/1.0 μg/ml). C. guilliermondii, a species that exhibits reduced susceptibility to fluconazole, is the sixth most frequently isolated Candida species from this large survey and may be an emerging pathogen in Latin America.",
author = "Pfaller, {M. A.} and Diekema, {D. J.} and M. Mendez and C. Kibbler and P. Erzsebet and Chang, {S. C.} and Gibbs, {D. L.} and Newell, {V. A.} and Jorge Finquelievich and Nora Tiraboschi and David Ellis and Dominique Frameree and {van den Abeele}, Annemarie and Senterre, {Jean Marc} and Arnaldo Colombo and Robert Rennie and Steve Sanche and Bijie Hu and Yingchun Xu and Yingyuan Zhang and Zhong, {Nan Shan} and Pilar Rivas and Angela Restrepo and Catalina Bedout and Ricardo Vega and Matilde Mendez and Nada Mallatova and Stanislava Dobiasova and Julio Ayabaca and Jeannete Zurita and M. Mallie and E. Candolfi and W. Fegeler and A. Haase and G. Rodloff and W. Bar and V. Czaika and George Petrikos and Erzs{\'e}bet Pusk{\'a}s and Ilona Doczi and Mestyan Gyula and Radka Nikolova and Uma Banerjee and Nathan Keller and Vivian Tullio and {Carlo Schito}, Gian and Giacomo Fortina and {Piero Testore}, Gian and Domenico D'Antonio and Giorgio Scalise and Pietro Martino and Graziana Manno and Kee Peng and Celia Alpuche and Jose Santos and {Rodriguez Noriega}, Eduardo and Mussaret Zaidi and Meis, {Jacques F.G.M.} and Egil Lingaas and Danuta Dzierzanowska and Waclaw Pawliszyn and {Luz Martins}, Mariada and Luis Albuquerque and Laura Rosado and Rosa Velho and Jose Amorim and Ilina, {Vera N.} and Kretchikova, {Olga I.} and Klyasova, {Galina A.} and Rozanova, {Sophia M.} and Multykh, {Irina G.} and Klimko, {Nikolay N.} and Agapova, {Elena D.} and Dmitrieva, {Natalya V.} and Al-Rasheed, {Abdul Mohsen} and Jan Trupl and Leon Langsadl and Alena Vaculikova and Hupkova Helena and Denise Roditi and Anwar Hoosen and Crewe-Brown, {H. H.} and {Janse van Rensburg}, {M. N.} and Adriano Duse and Kyungwon Lee and Kim, {Mi Na} and {del Palacio}, A. and Aurora Sanchez-Sousa and Jacques Bille and K. Muhlethaler and Wang, {Jen Hsien} and Malai Vorachit and Deniz Gur and Volkan Korten and John Paul and Brian Jones and {Kate Gould}, F. and Chris Kibbler and Nigel Weightman and Gould, {Ian M.} and Ruth Ashbee and Rosemarie Barnes and Jose Vazquez and Ed Chan and Davise Larone and {Jo Baron}, Ellen and Ghannoum, {Mahmoud A.} and Mike Rinaldi and Kevin Hazen and Elyse Foraker and Heidi Reyes and Axel Santiago",
year = "2006",
month = "10",
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pages = "3551--3556",
journal = "Journal of Clinical Microbiology",
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publisher = "American Society for Microbiology",
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Pfaller, MA, Diekema, DJ, Mendez, M, Kibbler, C, Erzsebet, P, Chang, SC, Gibbs, DL, Newell, VA, Finquelievich, J, Tiraboschi, N, Ellis, D, Frameree, D, van den Abeele, A, Senterre, JM, Colombo, A, Rennie, R, Sanche, S, Hu, B, Xu, Y, Zhang, Y, Zhong, NS, Rivas, P, Restrepo, A, Bedout, C, Vega, R, Mendez, M, Mallatova, N, Dobiasova, S, Ayabaca, J, Zurita, J, Mallie, M, Candolfi, E, Fegeler, W, Haase, A, Rodloff, G, Bar, W, Czaika, V, Petrikos, G, Puskás, E, Doczi, I, Gyula, M, Nikolova, R, Banerjee, U, Keller, N, Tullio, V, Carlo Schito, G, Fortina, G, Piero Testore, G, D'Antonio, D, Scalise, G, Martino, P, Manno, G, Peng, K, Alpuche, C, Santos, J, Rodriguez Noriega, E, Zaidi, M, Meis, JFGM, Lingaas, E, Dzierzanowska, D, Pawliszyn, W, Luz Martins, M, Albuquerque, L, Rosado, L, Velho, R, Amorim, J, Ilina, VN, Kretchikova, OI, Klyasova, GA, Rozanova, SM, Multykh, IG, Klimko, NN, Agapova, ED, Dmitrieva, NV, Al-Rasheed, AM, Trupl, J, Langsadl, L, Vaculikova, A, Helena, H, Roditi, D, Hoosen, A, Crewe-Brown, HH, Janse van Rensburg, MN, Duse, A, Lee, K, Kim, MN, del Palacio, A, Sanchez-Sousa, A, Bille, J, Muhlethaler, K, Wang, JH, Vorachit, M, Gur, D, Korten, V, Paul, J, Jones, B, Kate Gould, F, Kibbler, C, Weightman, N, Gould, IM, Ashbee, R, Barnes, R, Vazquez, J, Chan, E, Larone, D, Jo Baron, E, Ghannoum, MA, Rinaldi, M, Hazen, K, Foraker, E, Reyes, H & Santiago, A 2006, 'Candida guilliermondii, an opportunistic fungal pathogen with decreased susceptibility to fluconazole: Geographic and temporal trends from the ARTEMIS DISK antifungal surveillance program', Journal of Clinical Microbiology, vol. 44, no. 10, pp. 3551-3556. https://doi.org/10.1128/JCM.00865-06

Candida guilliermondii, an opportunistic fungal pathogen with decreased susceptibility to fluconazole : Geographic and temporal trends from the ARTEMIS DISK antifungal surveillance program. / Pfaller, M. A.; Diekema, D. J.; Mendez, M.; Kibbler, C.; Erzsebet, P.; Chang, S. C.; Gibbs, D. L.; Newell, V. A.; Finquelievich, Jorge; Tiraboschi, Nora; Ellis, David; Frameree, Dominique; van den Abeele, Annemarie; Senterre, Jean Marc; Colombo, Arnaldo; Rennie, Robert; Sanche, Steve; Hu, Bijie; Xu, Yingchun; Zhang, Yingyuan; Zhong, Nan Shan; Rivas, Pilar; Restrepo, Angela; Bedout, Catalina; Vega, Ricardo; Mendez, Matilde; Mallatova, Nada; Dobiasova, Stanislava; Ayabaca, Julio; Zurita, Jeannete; Mallie, M.; Candolfi, E.; Fegeler, W.; Haase, A.; Rodloff, G.; Bar, W.; Czaika, V.; Petrikos, George; Puskás, Erzsébet; Doczi, Ilona; Gyula, Mestyan; Nikolova, Radka; Banerjee, Uma; Keller, Nathan; Tullio, Vivian; Carlo Schito, Gian; Fortina, Giacomo; Piero Testore, Gian; D'Antonio, Domenico; Scalise, Giorgio; Martino, Pietro; Manno, Graziana; Peng, Kee; Alpuche, Celia; Santos, Jose; Rodriguez Noriega, Eduardo; Zaidi, Mussaret; Meis, Jacques F.G.M.; Lingaas, Egil; Dzierzanowska, Danuta; Pawliszyn, Waclaw; Luz Martins, Mariada; Albuquerque, Luis; Rosado, Laura; Velho, Rosa; Amorim, Jose; Ilina, Vera N.; Kretchikova, Olga I.; Klyasova, Galina A.; Rozanova, Sophia M.; Multykh, Irina G.; Klimko, Nikolay N.; Agapova, Elena D.; Dmitrieva, Natalya V.; Al-Rasheed, Abdul Mohsen; Trupl, Jan; Langsadl, Leon; Vaculikova, Alena; Helena, Hupkova; Roditi, Denise; Hoosen, Anwar; Crewe-Brown, H. H.; Janse van Rensburg, M. N.; Duse, Adriano; Lee, Kyungwon; Kim, Mi Na; del Palacio, A.; Sanchez-Sousa, Aurora; Bille, Jacques; Muhlethaler, K.; Wang, Jen Hsien; Vorachit, Malai; Gur, Deniz; Korten, Volkan; Paul, John; Jones, Brian; Kate Gould, F.; Kibbler, Chris; Weightman, Nigel; Gould, Ian M.; Ashbee, Ruth; Barnes, Rosemarie; Vazquez, Jose; Chan, Ed; Larone, Davise; Jo Baron, Ellen; Ghannoum, Mahmoud A.; Rinaldi, Mike; Hazen, Kevin; Foraker, Elyse; Reyes, Heidi; Santiago, Axel.

In: Journal of Clinical Microbiology, Vol. 44, No. 10, 01.10.2006, p. 3551-3556.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Candida guilliermondii, an opportunistic fungal pathogen with decreased susceptibility to fluconazole

T2 - Geographic and temporal trends from the ARTEMIS DISK antifungal surveillance program

AU - Pfaller, M. A.

AU - Diekema, D. J.

AU - Mendez, M.

AU - Kibbler, C.

AU - Erzsebet, P.

AU - Chang, S. C.

AU - Gibbs, D. L.

AU - Newell, V. A.

AU - Finquelievich, Jorge

AU - Tiraboschi, Nora

AU - Ellis, David

AU - Frameree, Dominique

AU - van den Abeele, Annemarie

AU - Senterre, Jean Marc

AU - Colombo, Arnaldo

AU - Rennie, Robert

AU - Sanche, Steve

AU - Hu, Bijie

AU - Xu, Yingchun

AU - Zhang, Yingyuan

AU - Zhong, Nan Shan

AU - Rivas, Pilar

AU - Restrepo, Angela

AU - Bedout, Catalina

AU - Vega, Ricardo

AU - Mendez, Matilde

AU - Mallatova, Nada

AU - Dobiasova, Stanislava

AU - Ayabaca, Julio

AU - Zurita, Jeannete

AU - Mallie, M.

AU - Candolfi, E.

AU - Fegeler, W.

AU - Haase, A.

AU - Rodloff, G.

AU - Bar, W.

AU - Czaika, V.

AU - Petrikos, George

AU - Puskás, Erzsébet

AU - Doczi, Ilona

AU - Gyula, Mestyan

AU - Nikolova, Radka

AU - Banerjee, Uma

AU - Keller, Nathan

AU - Tullio, Vivian

AU - Carlo Schito, Gian

AU - Fortina, Giacomo

AU - Piero Testore, Gian

AU - D'Antonio, Domenico

AU - Scalise, Giorgio

AU - Martino, Pietro

AU - Manno, Graziana

AU - Peng, Kee

AU - Alpuche, Celia

AU - Santos, Jose

AU - Rodriguez Noriega, Eduardo

AU - Zaidi, Mussaret

AU - Meis, Jacques F.G.M.

AU - Lingaas, Egil

AU - Dzierzanowska, Danuta

AU - Pawliszyn, Waclaw

AU - Luz Martins, Mariada

AU - Albuquerque, Luis

AU - Rosado, Laura

AU - Velho, Rosa

AU - Amorim, Jose

AU - Ilina, Vera N.

AU - Kretchikova, Olga I.

AU - Klyasova, Galina A.

AU - Rozanova, Sophia M.

AU - Multykh, Irina G.

AU - Klimko, Nikolay N.

AU - Agapova, Elena D.

AU - Dmitrieva, Natalya V.

AU - Al-Rasheed, Abdul Mohsen

AU - Trupl, Jan

AU - Langsadl, Leon

AU - Vaculikova, Alena

AU - Helena, Hupkova

AU - Roditi, Denise

AU - Hoosen, Anwar

AU - Crewe-Brown, H. H.

AU - Janse van Rensburg, M. N.

AU - Duse, Adriano

AU - Lee, Kyungwon

AU - Kim, Mi Na

AU - del Palacio, A.

AU - Sanchez-Sousa, Aurora

AU - Bille, Jacques

AU - Muhlethaler, K.

AU - Wang, Jen Hsien

AU - Vorachit, Malai

AU - Gur, Deniz

AU - Korten, Volkan

AU - Paul, John

AU - Jones, Brian

AU - Kate Gould, F.

AU - Kibbler, Chris

AU - Weightman, Nigel

AU - Gould, Ian M.

AU - Ashbee, Ruth

AU - Barnes, Rosemarie

AU - Vazquez, Jose

AU - Chan, Ed

AU - Larone, Davise

AU - Jo Baron, Ellen

AU - Ghannoum, Mahmoud A.

AU - Rinaldi, Mike

AU - Hazen, Kevin

AU - Foraker, Elyse

AU - Reyes, Heidi

AU - Santiago, Axel

PY - 2006/10/1

Y1 - 2006/10/1

N2 - Although a rare cause of invasive candidiasis, Candida guilliermondii has been reported to exhibit decreased susceptibility to antifungal agents. Aside from case reports and small surveys, there is little information regarding the epidemiology and antifungal susceptibility profile of C. guilliermondii. We report geographic and temporal trends in the isolation and antifungal susceptibilities of 1,029 C. guilliermondii clinical isolates collected from 127 medical centers as part of the ARTEMIS DISK Antifungal Surveillance Program. In addition, we report the in vitro susceptibility of 132 bloodstream isolates of C. guilliermondii to caspofungin. C. guilliermondii represented 1.4% of the 75,761 isolates collected from 2001 to 2003 and was most common among isolates from Latin America (3.7% versus 0.6 to 1.1%). Decreased susceptibility to fluconazole was noted (75% susceptible; range, 68 to 77% across regions), and voriconazole was more active in vitro against C. guilliermondii than fluconazole (91% susceptible; range, 88 to 93% across regions). Fluconazole was least active against isolates from dermatology (58%) and surgical (69%) services and against isolates associated with skin and soft tissue infection (68%, compared to 85% susceptible for bloodstream isolates). There was no evidence of increasing azole resistance over time among C. guilliermondii isolates tested from 2001 to 2003. Of 132 bloodstream isolates of C. guilliermondii tested against caspofungin, most were inhibited by ≤2 μg/ml (96%; MIC 50/MIC90, 0.5/1.0 μg/ml). C. guilliermondii, a species that exhibits reduced susceptibility to fluconazole, is the sixth most frequently isolated Candida species from this large survey and may be an emerging pathogen in Latin America.

AB - Although a rare cause of invasive candidiasis, Candida guilliermondii has been reported to exhibit decreased susceptibility to antifungal agents. Aside from case reports and small surveys, there is little information regarding the epidemiology and antifungal susceptibility profile of C. guilliermondii. We report geographic and temporal trends in the isolation and antifungal susceptibilities of 1,029 C. guilliermondii clinical isolates collected from 127 medical centers as part of the ARTEMIS DISK Antifungal Surveillance Program. In addition, we report the in vitro susceptibility of 132 bloodstream isolates of C. guilliermondii to caspofungin. C. guilliermondii represented 1.4% of the 75,761 isolates collected from 2001 to 2003 and was most common among isolates from Latin America (3.7% versus 0.6 to 1.1%). Decreased susceptibility to fluconazole was noted (75% susceptible; range, 68 to 77% across regions), and voriconazole was more active in vitro against C. guilliermondii than fluconazole (91% susceptible; range, 88 to 93% across regions). Fluconazole was least active against isolates from dermatology (58%) and surgical (69%) services and against isolates associated with skin and soft tissue infection (68%, compared to 85% susceptible for bloodstream isolates). There was no evidence of increasing azole resistance over time among C. guilliermondii isolates tested from 2001 to 2003. Of 132 bloodstream isolates of C. guilliermondii tested against caspofungin, most were inhibited by ≤2 μg/ml (96%; MIC 50/MIC90, 0.5/1.0 μg/ml). C. guilliermondii, a species that exhibits reduced susceptibility to fluconazole, is the sixth most frequently isolated Candida species from this large survey and may be an emerging pathogen in Latin America.

UR - http://www.scopus.com/inward/record.url?scp=33947506669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947506669&partnerID=8YFLogxK

U2 - 10.1128/JCM.00865-06

DO - 10.1128/JCM.00865-06

M3 - Article

VL - 44

SP - 3551

EP - 3556

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 10

ER -