Candida rugosa, an emerging fungal pathogen with resistance to azoles

Geographic and temporal trends from the ARTEMIS DISK Antifungal Surveillance Program

M. A. Pfaller, D. J. Diekema, A. L. Colombo, C. Kibbler, K. P. Ng, D. L. Gibbs, V. A. Newell, Jorge Finquelievich, Nora Tiraboschi, David Ellis, Dominique Frameree, Annemarie van den Abeele, Jean Marc Senterre, Arnaldo Colombo, Robert Rennie, Steve Sanche, Bijie Hu, Yingchun Xu, Yingyuan Zhang, Nan Shan Zhong & 92 others Pilar Rivas, Angela Restrepo, Catalina Bedout, Ricardo Vega, Matilde Mendez, Nada Mallatova, Stanislava Dobiasova, Julio Ayabaca, Jeannete Zurita, M. Mallie, E. Candolfi, W. Fegeler, A. Haase, G. Rodloff, W. Bar, V. Czaika, George Petrikos, Erzsébet Puskás, Ilona Doczi, Mestyan Gyula, Radka Nikolova, Uma Banerjee, Nathan Keller, Vivian Tullio, Gian Carlo Schito, Giacomo Fortina, Gian Piero Testore, Domenico D'Antonio, Giorgio Scalise, Pietro Martino, Graziana Manno, Kee Peng, Celia Alpuche, Jose Santos, Eduardo Rodriguez Noriega, Mussaret Zaidi, Jacques F.G.M. Meis, Egil Lingaas, Danuta Dzierzanowska, Waclaw Pawliszyn, Mariada Luz Martins, Luis Albuquerque, Laura Rosado, Rosa Velho, Jose Amorim, Vera N. Ilina, Olga I. Kretchikova, Galina A. Klyasova, Sophia M. Rozanova, Irina G. Multykh, Nikolay N. Klimko, Elena D. Agapova, Natalya V. Dmitrieva, Abdul Mohsen Al-Rasheed, Jan Trupl, Leon Langsadl, Alena Vaculikova, Hupkova Helena, Denise Roditi, Anwar Hoosen, H. H. Crewe-Brown, M. N. Janse van Rensburg, Adriano Duse, Kyungwon Lee, Mi Na Kim, A. del Palacio, Aurora Sanchez-Sousa, Jacques Bille, K. Muhlethaler, Shan Chwen Chang, Jen Hsien Wang, Malai Vorachit, Deniz Gur, Volkan Korten, John Paul, Brian Jones, F. Kate Gould, Chris Kibbler, Nigel Weightman, Ian M. Gould, Ruth Ashbee, Rosemarie Barnes, Jose Vazquez, Ed Chan, Davise Larone, Ellen Jo Baron, Mahmoud A. Ghannoum, Mike Rinaldi, Kevin Hazen, Elyse Foraker, Heidi Reyes, Axel Santiago

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Candida rugosa is a fungus that appears to be emerging as a cause of infection in some geographic regions. We utilized the extensive database of the ARTEMIS DISK Antifungal Surveillance Program to describe the geographic and temporal trends in the isolation of C. rugosa from clinical specimens and the in vitro susceptibilities of 452 isolates to fluconazole and voriconazole. C. rugosa accounted for 0.4% of 134,715 isolates of Candida, and the frequency of isolation increased from 0.03% to 0.4% over the 6.5-year study period (1997 to 2003). C. rugosa was most common in the Latin American region (2.7% versus 0.1 to 0.4%). Decreased susceptibility to fluconazole (40.5% susceptible) was observed in all geographic regions; however, isolates from Europe and North America were much more susceptible (97 to 100%) to voriconazole than those from other geographic regions (55.8 to 58.8%). C. rugosa was most often isolated from blood and urine in patients hospitalized at the Medical and Surgical inpatient services. Notably, bloodstream isolates were the least susceptible to both fluconazole and voriconazole. C. rugosa should be considered, along with the established pathogens Candida krusei and Candida glabrata, as a species of Candida with reduced susceptibility to the azole antifungal agents.

Original languageEnglish
Pages (from-to)3578-3582
Number of pages5
JournalJournal of Clinical Microbiology
Volume44
Issue number10
DOIs
Publication statusPublished - 2006 Oct 1

Fingerprint

Azoles
Candida
Fluconazole
Candida glabrata
Antifungal Agents
North America
Inpatients
Fungi
Urine
Databases
Infection
Voriconazole

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

Cite this

Pfaller, M. A. ; Diekema, D. J. ; Colombo, A. L. ; Kibbler, C. ; Ng, K. P. ; Gibbs, D. L. ; Newell, V. A. ; Finquelievich, Jorge ; Tiraboschi, Nora ; Ellis, David ; Frameree, Dominique ; van den Abeele, Annemarie ; Senterre, Jean Marc ; Colombo, Arnaldo ; Rennie, Robert ; Sanche, Steve ; Hu, Bijie ; Xu, Yingchun ; Zhang, Yingyuan ; Zhong, Nan Shan ; Rivas, Pilar ; Restrepo, Angela ; Bedout, Catalina ; Vega, Ricardo ; Mendez, Matilde ; Mallatova, Nada ; Dobiasova, Stanislava ; Ayabaca, Julio ; Zurita, Jeannete ; Mallie, M. ; Candolfi, E. ; Fegeler, W. ; Haase, A. ; Rodloff, G. ; Bar, W. ; Czaika, V. ; Petrikos, George ; Puskás, Erzsébet ; Doczi, Ilona ; Gyula, Mestyan ; Nikolova, Radka ; Banerjee, Uma ; Keller, Nathan ; Tullio, Vivian ; Carlo Schito, Gian ; Fortina, Giacomo ; Piero Testore, Gian ; D'Antonio, Domenico ; Scalise, Giorgio ; Martino, Pietro ; Manno, Graziana ; Peng, Kee ; Alpuche, Celia ; Santos, Jose ; Rodriguez Noriega, Eduardo ; Zaidi, Mussaret ; Meis, Jacques F.G.M. ; Lingaas, Egil ; Dzierzanowska, Danuta ; Pawliszyn, Waclaw ; Luz Martins, Mariada ; Albuquerque, Luis ; Rosado, Laura ; Velho, Rosa ; Amorim, Jose ; Ilina, Vera N. ; Kretchikova, Olga I. ; Klyasova, Galina A. ; Rozanova, Sophia M. ; Multykh, Irina G. ; Klimko, Nikolay N. ; Agapova, Elena D. ; Dmitrieva, Natalya V. ; Al-Rasheed, Abdul Mohsen ; Trupl, Jan ; Langsadl, Leon ; Vaculikova, Alena ; Helena, Hupkova ; Roditi, Denise ; Hoosen, Anwar ; Crewe-Brown, H. H. ; Janse van Rensburg, M. N. ; Duse, Adriano ; Lee, Kyungwon ; Kim, Mi Na ; del Palacio, A. ; Sanchez-Sousa, Aurora ; Bille, Jacques ; Muhlethaler, K. ; Chang, Shan Chwen ; Wang, Jen Hsien ; Vorachit, Malai ; Gur, Deniz ; Korten, Volkan ; Paul, John ; Jones, Brian ; Kate Gould, F. ; Kibbler, Chris ; Weightman, Nigel ; Gould, Ian M. ; Ashbee, Ruth ; Barnes, Rosemarie ; Vazquez, Jose ; Chan, Ed ; Larone, Davise ; Jo Baron, Ellen ; Ghannoum, Mahmoud A. ; Rinaldi, Mike ; Hazen, Kevin ; Foraker, Elyse ; Reyes, Heidi ; Santiago, Axel. / Candida rugosa, an emerging fungal pathogen with resistance to azoles : Geographic and temporal trends from the ARTEMIS DISK Antifungal Surveillance Program. In: Journal of Clinical Microbiology. 2006 ; Vol. 44, No. 10. pp. 3578-3582.
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abstract = "Candida rugosa is a fungus that appears to be emerging as a cause of infection in some geographic regions. We utilized the extensive database of the ARTEMIS DISK Antifungal Surveillance Program to describe the geographic and temporal trends in the isolation of C. rugosa from clinical specimens and the in vitro susceptibilities of 452 isolates to fluconazole and voriconazole. C. rugosa accounted for 0.4{\%} of 134,715 isolates of Candida, and the frequency of isolation increased from 0.03{\%} to 0.4{\%} over the 6.5-year study period (1997 to 2003). C. rugosa was most common in the Latin American region (2.7{\%} versus 0.1 to 0.4{\%}). Decreased susceptibility to fluconazole (40.5{\%} susceptible) was observed in all geographic regions; however, isolates from Europe and North America were much more susceptible (97 to 100{\%}) to voriconazole than those from other geographic regions (55.8 to 58.8{\%}). C. rugosa was most often isolated from blood and urine in patients hospitalized at the Medical and Surgical inpatient services. Notably, bloodstream isolates were the least susceptible to both fluconazole and voriconazole. C. rugosa should be considered, along with the established pathogens Candida krusei and Candida glabrata, as a species of Candida with reduced susceptibility to the azole antifungal agents.",
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Pfaller, MA, Diekema, DJ, Colombo, AL, Kibbler, C, Ng, KP, Gibbs, DL, Newell, VA, Finquelievich, J, Tiraboschi, N, Ellis, D, Frameree, D, van den Abeele, A, Senterre, JM, Colombo, A, Rennie, R, Sanche, S, Hu, B, Xu, Y, Zhang, Y, Zhong, NS, Rivas, P, Restrepo, A, Bedout, C, Vega, R, Mendez, M, Mallatova, N, Dobiasova, S, Ayabaca, J, Zurita, J, Mallie, M, Candolfi, E, Fegeler, W, Haase, A, Rodloff, G, Bar, W, Czaika, V, Petrikos, G, Puskás, E, Doczi, I, Gyula, M, Nikolova, R, Banerjee, U, Keller, N, Tullio, V, Carlo Schito, G, Fortina, G, Piero Testore, G, D'Antonio, D, Scalise, G, Martino, P, Manno, G, Peng, K, Alpuche, C, Santos, J, Rodriguez Noriega, E, Zaidi, M, Meis, JFGM, Lingaas, E, Dzierzanowska, D, Pawliszyn, W, Luz Martins, M, Albuquerque, L, Rosado, L, Velho, R, Amorim, J, Ilina, VN, Kretchikova, OI, Klyasova, GA, Rozanova, SM, Multykh, IG, Klimko, NN, Agapova, ED, Dmitrieva, NV, Al-Rasheed, AM, Trupl, J, Langsadl, L, Vaculikova, A, Helena, H, Roditi, D, Hoosen, A, Crewe-Brown, HH, Janse van Rensburg, MN, Duse, A, Lee, K, Kim, MN, del Palacio, A, Sanchez-Sousa, A, Bille, J, Muhlethaler, K, Chang, SC, Wang, JH, Vorachit, M, Gur, D, Korten, V, Paul, J, Jones, B, Kate Gould, F, Kibbler, C, Weightman, N, Gould, IM, Ashbee, R, Barnes, R, Vazquez, J, Chan, E, Larone, D, Jo Baron, E, Ghannoum, MA, Rinaldi, M, Hazen, K, Foraker, E, Reyes, H & Santiago, A 2006, 'Candida rugosa, an emerging fungal pathogen with resistance to azoles: Geographic and temporal trends from the ARTEMIS DISK Antifungal Surveillance Program', Journal of Clinical Microbiology, vol. 44, no. 10, pp. 3578-3582. https://doi.org/10.1128/JCM.00863-06

Candida rugosa, an emerging fungal pathogen with resistance to azoles : Geographic and temporal trends from the ARTEMIS DISK Antifungal Surveillance Program. / Pfaller, M. A.; Diekema, D. J.; Colombo, A. L.; Kibbler, C.; Ng, K. P.; Gibbs, D. L.; Newell, V. A.; Finquelievich, Jorge; Tiraboschi, Nora; Ellis, David; Frameree, Dominique; van den Abeele, Annemarie; Senterre, Jean Marc; Colombo, Arnaldo; Rennie, Robert; Sanche, Steve; Hu, Bijie; Xu, Yingchun; Zhang, Yingyuan; Zhong, Nan Shan; Rivas, Pilar; Restrepo, Angela; Bedout, Catalina; Vega, Ricardo; Mendez, Matilde; Mallatova, Nada; Dobiasova, Stanislava; Ayabaca, Julio; Zurita, Jeannete; Mallie, M.; Candolfi, E.; Fegeler, W.; Haase, A.; Rodloff, G.; Bar, W.; Czaika, V.; Petrikos, George; Puskás, Erzsébet; Doczi, Ilona; Gyula, Mestyan; Nikolova, Radka; Banerjee, Uma; Keller, Nathan; Tullio, Vivian; Carlo Schito, Gian; Fortina, Giacomo; Piero Testore, Gian; D'Antonio, Domenico; Scalise, Giorgio; Martino, Pietro; Manno, Graziana; Peng, Kee; Alpuche, Celia; Santos, Jose; Rodriguez Noriega, Eduardo; Zaidi, Mussaret; Meis, Jacques F.G.M.; Lingaas, Egil; Dzierzanowska, Danuta; Pawliszyn, Waclaw; Luz Martins, Mariada; Albuquerque, Luis; Rosado, Laura; Velho, Rosa; Amorim, Jose; Ilina, Vera N.; Kretchikova, Olga I.; Klyasova, Galina A.; Rozanova, Sophia M.; Multykh, Irina G.; Klimko, Nikolay N.; Agapova, Elena D.; Dmitrieva, Natalya V.; Al-Rasheed, Abdul Mohsen; Trupl, Jan; Langsadl, Leon; Vaculikova, Alena; Helena, Hupkova; Roditi, Denise; Hoosen, Anwar; Crewe-Brown, H. H.; Janse van Rensburg, M. N.; Duse, Adriano; Lee, Kyungwon; Kim, Mi Na; del Palacio, A.; Sanchez-Sousa, Aurora; Bille, Jacques; Muhlethaler, K.; Chang, Shan Chwen; Wang, Jen Hsien; Vorachit, Malai; Gur, Deniz; Korten, Volkan; Paul, John; Jones, Brian; Kate Gould, F.; Kibbler, Chris; Weightman, Nigel; Gould, Ian M.; Ashbee, Ruth; Barnes, Rosemarie; Vazquez, Jose; Chan, Ed; Larone, Davise; Jo Baron, Ellen; Ghannoum, Mahmoud A.; Rinaldi, Mike; Hazen, Kevin; Foraker, Elyse; Reyes, Heidi; Santiago, Axel.

In: Journal of Clinical Microbiology, Vol. 44, No. 10, 01.10.2006, p. 3578-3582.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Candida rugosa, an emerging fungal pathogen with resistance to azoles

T2 - Geographic and temporal trends from the ARTEMIS DISK Antifungal Surveillance Program

AU - Pfaller, M. A.

AU - Diekema, D. J.

AU - Colombo, A. L.

AU - Kibbler, C.

AU - Ng, K. P.

AU - Gibbs, D. L.

AU - Newell, V. A.

AU - Finquelievich, Jorge

AU - Tiraboschi, Nora

AU - Ellis, David

AU - Frameree, Dominique

AU - van den Abeele, Annemarie

AU - Senterre, Jean Marc

AU - Colombo, Arnaldo

AU - Rennie, Robert

AU - Sanche, Steve

AU - Hu, Bijie

AU - Xu, Yingchun

AU - Zhang, Yingyuan

AU - Zhong, Nan Shan

AU - Rivas, Pilar

AU - Restrepo, Angela

AU - Bedout, Catalina

AU - Vega, Ricardo

AU - Mendez, Matilde

AU - Mallatova, Nada

AU - Dobiasova, Stanislava

AU - Ayabaca, Julio

AU - Zurita, Jeannete

AU - Mallie, M.

AU - Candolfi, E.

AU - Fegeler, W.

AU - Haase, A.

AU - Rodloff, G.

AU - Bar, W.

AU - Czaika, V.

AU - Petrikos, George

AU - Puskás, Erzsébet

AU - Doczi, Ilona

AU - Gyula, Mestyan

AU - Nikolova, Radka

AU - Banerjee, Uma

AU - Keller, Nathan

AU - Tullio, Vivian

AU - Carlo Schito, Gian

AU - Fortina, Giacomo

AU - Piero Testore, Gian

AU - D'Antonio, Domenico

AU - Scalise, Giorgio

AU - Martino, Pietro

AU - Manno, Graziana

AU - Peng, Kee

AU - Alpuche, Celia

AU - Santos, Jose

AU - Rodriguez Noriega, Eduardo

AU - Zaidi, Mussaret

AU - Meis, Jacques F.G.M.

AU - Lingaas, Egil

AU - Dzierzanowska, Danuta

AU - Pawliszyn, Waclaw

AU - Luz Martins, Mariada

AU - Albuquerque, Luis

AU - Rosado, Laura

AU - Velho, Rosa

AU - Amorim, Jose

AU - Ilina, Vera N.

AU - Kretchikova, Olga I.

AU - Klyasova, Galina A.

AU - Rozanova, Sophia M.

AU - Multykh, Irina G.

AU - Klimko, Nikolay N.

AU - Agapova, Elena D.

AU - Dmitrieva, Natalya V.

AU - Al-Rasheed, Abdul Mohsen

AU - Trupl, Jan

AU - Langsadl, Leon

AU - Vaculikova, Alena

AU - Helena, Hupkova

AU - Roditi, Denise

AU - Hoosen, Anwar

AU - Crewe-Brown, H. H.

AU - Janse van Rensburg, M. N.

AU - Duse, Adriano

AU - Lee, Kyungwon

AU - Kim, Mi Na

AU - del Palacio, A.

AU - Sanchez-Sousa, Aurora

AU - Bille, Jacques

AU - Muhlethaler, K.

AU - Chang, Shan Chwen

AU - Wang, Jen Hsien

AU - Vorachit, Malai

AU - Gur, Deniz

AU - Korten, Volkan

AU - Paul, John

AU - Jones, Brian

AU - Kate Gould, F.

AU - Kibbler, Chris

AU - Weightman, Nigel

AU - Gould, Ian M.

AU - Ashbee, Ruth

AU - Barnes, Rosemarie

AU - Vazquez, Jose

AU - Chan, Ed

AU - Larone, Davise

AU - Jo Baron, Ellen

AU - Ghannoum, Mahmoud A.

AU - Rinaldi, Mike

AU - Hazen, Kevin

AU - Foraker, Elyse

AU - Reyes, Heidi

AU - Santiago, Axel

PY - 2006/10/1

Y1 - 2006/10/1

N2 - Candida rugosa is a fungus that appears to be emerging as a cause of infection in some geographic regions. We utilized the extensive database of the ARTEMIS DISK Antifungal Surveillance Program to describe the geographic and temporal trends in the isolation of C. rugosa from clinical specimens and the in vitro susceptibilities of 452 isolates to fluconazole and voriconazole. C. rugosa accounted for 0.4% of 134,715 isolates of Candida, and the frequency of isolation increased from 0.03% to 0.4% over the 6.5-year study period (1997 to 2003). C. rugosa was most common in the Latin American region (2.7% versus 0.1 to 0.4%). Decreased susceptibility to fluconazole (40.5% susceptible) was observed in all geographic regions; however, isolates from Europe and North America were much more susceptible (97 to 100%) to voriconazole than those from other geographic regions (55.8 to 58.8%). C. rugosa was most often isolated from blood and urine in patients hospitalized at the Medical and Surgical inpatient services. Notably, bloodstream isolates were the least susceptible to both fluconazole and voriconazole. C. rugosa should be considered, along with the established pathogens Candida krusei and Candida glabrata, as a species of Candida with reduced susceptibility to the azole antifungal agents.

AB - Candida rugosa is a fungus that appears to be emerging as a cause of infection in some geographic regions. We utilized the extensive database of the ARTEMIS DISK Antifungal Surveillance Program to describe the geographic and temporal trends in the isolation of C. rugosa from clinical specimens and the in vitro susceptibilities of 452 isolates to fluconazole and voriconazole. C. rugosa accounted for 0.4% of 134,715 isolates of Candida, and the frequency of isolation increased from 0.03% to 0.4% over the 6.5-year study period (1997 to 2003). C. rugosa was most common in the Latin American region (2.7% versus 0.1 to 0.4%). Decreased susceptibility to fluconazole (40.5% susceptible) was observed in all geographic regions; however, isolates from Europe and North America were much more susceptible (97 to 100%) to voriconazole than those from other geographic regions (55.8 to 58.8%). C. rugosa was most often isolated from blood and urine in patients hospitalized at the Medical and Surgical inpatient services. Notably, bloodstream isolates were the least susceptible to both fluconazole and voriconazole. C. rugosa should be considered, along with the established pathogens Candida krusei and Candida glabrata, as a species of Candida with reduced susceptibility to the azole antifungal agents.

UR - http://www.scopus.com/inward/record.url?scp=33947634712&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947634712&partnerID=8YFLogxK

U2 - 10.1128/JCM.00863-06

DO - 10.1128/JCM.00863-06

M3 - Article

VL - 44

SP - 3578

EP - 3582

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 10

ER -