TY - GEN
T1 - Capacitance based real time monitoring of three kinds of endocytosis
AU - Lee, Ri Mi
AU - Kim, Pyunghwan
AU - Kim, Kyujung
AU - Kim, Kyung Mi
AU - Kim, Donghyun
AU - Yun, Chaeok
AU - Shin, Jeon Soo
AU - Yoo, Kyung Hwa
PY - 2011
Y1 - 2011
N2 - Endocytosis is a process in which a substance gains entry into a cell without passing through the cell membrane. This process is subdivided into three different types, receptor mediated endocytosis, pinocytosis and phagocytosis. In this study, we developed a capacitance sensor to monitor endocytosis in real time. During the receptor mediated endocytosis, a capacitance peak was observed. In contrast, the capacitance declined without a capacitance peak when nanoparticles or bacteria were taken up via non-specific pinocytosis or phagotytosis. In addition, we have developed a capacitance sensor array to demonstrate capacitance-based high-throughput screening. These results demonstrated that three types of endocytosis are able to be differentiated using our capacitance sensor.
AB - Endocytosis is a process in which a substance gains entry into a cell without passing through the cell membrane. This process is subdivided into three different types, receptor mediated endocytosis, pinocytosis and phagocytosis. In this study, we developed a capacitance sensor to monitor endocytosis in real time. During the receptor mediated endocytosis, a capacitance peak was observed. In contrast, the capacitance declined without a capacitance peak when nanoparticles or bacteria were taken up via non-specific pinocytosis or phagotytosis. In addition, we have developed a capacitance sensor array to demonstrate capacitance-based high-throughput screening. These results demonstrated that three types of endocytosis are able to be differentiated using our capacitance sensor.
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M3 - Conference contribution
AN - SCOPUS:81455132892
SN - 9781439871386
T3 - Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
SP - 44
EP - 47
BT - Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
T2 - Nanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Y2 - 13 June 2011 through 16 June 2011
ER -