Capacitance based real time monitoring of three kinds of endocytosis

Ri Mi Lee, Pyunghwan Kim, Kyujung Kim, Kyung Mi Kim, Donghyun Kim, Chaeok Yun, Jeon Soo Shin, Kyung Hwa Yoo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Endocytosis is a process in which a substance gains entry into a cell without passing through the cell membrane. This process is subdivided into three different types, receptor mediated endocytosis, pinocytosis and phagocytosis. In this study, we developed a capacitance sensor to monitor endocytosis in real time. During the receptor mediated endocytosis, a capacitance peak was observed. In contrast, the capacitance declined without a capacitance peak when nanoparticles or bacteria were taken up via non-specific pinocytosis or phagotytosis. In addition, we have developed a capacitance sensor array to demonstrate capacitance-based high-throughput screening. These results demonstrated that three types of endocytosis are able to be differentiated using our capacitance sensor.

Original languageEnglish
Title of host publicationTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Pages44-47
Number of pages4
Publication statusPublished - 2011 Nov 23
EventNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 - Boston, MA, United States
Duration: 2011 Jun 132011 Jun 16

Publication series

NameTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Volume3

Other

OtherNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
CountryUnited States
CityBoston, MA
Period11/6/1311/6/16

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

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  • Cite this

    Lee, R. M., Kim, P., Kim, K., Kim, K. M., Kim, D., Yun, C., Shin, J. S., & Yoo, K. H. (2011). Capacitance based real time monitoring of three kinds of endocytosis. In Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 (pp. 44-47). (Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011; Vol. 3).