Capillary electrophoresis-electrochemistry microfluidic system for the determination of organic peroxides

Joseph Wang; Alberto Escarpa; Martin Pumera; Jason Feldman

doi:10.1016/S0021-9673(02)00075-4

Capillary electrophoresis-electrochemistry microfluidic system for the determination of organic peroxides

Joseph Wang, Alberto Escarpa, Martin Pumera, Jason Feldman

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

A microfluidic analytical system for the separation and detection of organic peroxides, based on a microchip capillary electrophoresis device with an integrated amperometric detector, was developed. The new microsystem relies on the reductive detection of both organic acid peroxides and hydroperoxides at -700 mV (vs. Ag wire/AgCl). Factors influencing the separation and detection processes were examined and optimized. The integrated microsystem offers rapid measurements (within 130 s) of these organic-peroxide compounds, down to micromolar levels. A highly stable response for repetitive injections (RSD 0.35-3.12%; n=12) reflects the negligible electrode passivation. Such a "lab-on-a-chip" device should be attractive for on-site analysis of organic peroxides, as desired for environmental screening and industrial monitoring.

Original language	English
Pages (from-to)	249-254
Number of pages	6
Journal	Journal of Chromatography A
Volume	952
Issue number	1-2
DOIs	https://doi.org/10.1016/S0021-9673(02)00075-4
Publication status	Published - 2002 Apr 5

Bibliographical note

Funding Information:
This research was supported by a grant from the Jet Propulsion Laboratory (of the California Institute of Technology). A.E. acknowledges the NATO fellowship from the European Union.

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Organic Chemistry

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title = "Capillary electrophoresis-electrochemistry microfluidic system for the determination of organic peroxides",

abstract = "A microfluidic analytical system for the separation and detection of organic peroxides, based on a microchip capillary electrophoresis device with an integrated amperometric detector, was developed. The new microsystem relies on the reductive detection of both organic acid peroxides and hydroperoxides at -700 mV (vs. Ag wire/AgCl). Factors influencing the separation and detection processes were examined and optimized. The integrated microsystem offers rapid measurements (within 130 s) of these organic-peroxide compounds, down to micromolar levels. A highly stable response for repetitive injections (RSD 0.35-3.12%; n=12) reflects the negligible electrode passivation. Such a {"}lab-on-a-chip{"} device should be attractive for on-site analysis of organic peroxides, as desired for environmental screening and industrial monitoring.",

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AU - Escarpa, Alberto

AU - Pumera, Martin

AU - Feldman, Jason

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