Carbapenemase-producing Enterobacteriaceae in South Korea: A report from the National Laboratory Surveillance System

Eun Jeong Yoon, Ji Woo Yang, Jung O.K. Kim, Hyukmin Lee, Kwang Jun Lee, Seok Hoon Jeong

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Aim: To assess the epidemiology of carbapenemase-producing Enterobacteriaceae (CPE) in South Korea. Materials & methods: From 2011 to 2015, 2487 carbapenem-nonsusceptible Enterobacteriaceae were collected through the Korean National Laboratory Surveillance System. Disk-diffusion for antimicrobial susceptibility, PCR/sequencing to detect carbapenemase genes and multilocus sequence typing for molecular epidemiology were carried out. Results: The number of carbapenem-nonsusceptible Enterobacteriaceae was increasing approximately 1.5-fold per year and the proportion of CPEs was exponentially confirmed from 2014. KPC was the most dominant, mostly associated with Klebsiella pneumoniae ST11 and ST307, NDM was the second and OXA-48-like was the third dominant carbapenemases. The IMP, VIM and GES-5 CPEs were identified sporadically. Conclusion: The nation-wide spreads of KPC, NDM and OXA-48-like CPEs were in an alarming epidemiological stage.

Original languageEnglish
Pages (from-to)771-783
Number of pages13
JournalFuture Microbiology
Volume13
Issue number7
DOIs
Publication statusPublished - 2018

Bibliographical note

Funding Information:
This research was supported by a research fund (2016-NI44001-00) from the Korean Centers for Disease Control and Prevention. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

Publisher Copyright:
© 2018 Future Medicine Ltd.

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)

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