Fifty-five mono- and disaccharide analogues were prepared and used for the construction of microarrays to uncover lectin-selective ligands. The microarray study showed that two disaccharide analogues, 28′ and 44′, selectively bind to Solanum tuberosum lectin (STL) and wheat germ agglutinin (WGA), respectively. Cell studies indicated that 28′ and 44′ selectively block the binding of STL and WGA to mammalian cells, unlike the natural ligand LacNAc, which suppresses binding of both STL and WGA to cells.
Bibliographical noteFunding Information:
This study was financially supported by the National Creative Research Initiative Program (2010?0018272) in Korea.
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All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Molecular Biology
- Organic Chemistry