Carbohydrate Analogue Microarrays for Identification of Lectin-Selective Ligands

Ji Young Hyun, Cheol Wan Park, Yanna Liu, Daeun Kwon, Seong Hyun Park, Sungjin Park, Jaeyoung Pai, Injae Shin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Fifty-five mono- and disaccharide analogues were prepared and used for the construction of microarrays to uncover lectin-selective ligands. The microarray study showed that two disaccharide analogues, 28′ and 44′, selectively bind to Solanum tuberosum lectin (STL) and wheat germ agglutinin (WGA), respectively. Cell studies indicated that 28′ and 44′ selectively block the binding of STL and WGA to mammalian cells, unlike the natural ligand LacNAc, which suppresses binding of both STL and WGA to cells.

Original languageEnglish
Pages (from-to)1077-1082
Number of pages6
JournalChemBioChem
Volume18
Issue number12
DOIs
Publication statusPublished - 2017 Jun 19

Fingerprint

Wheat Germ Agglutinins
Microarrays
Lectins
Solanum tuberosum
Disaccharides
Carbohydrates
Ligands
Monosaccharides
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

Cite this

Hyun, J. Y., Park, C. W., Liu, Y., Kwon, D., Park, S. H., Park, S., ... Shin, I. (2017). Carbohydrate Analogue Microarrays for Identification of Lectin-Selective Ligands. ChemBioChem, 18(12), 1077-1082. https://doi.org/10.1002/cbic.201700091
Hyun, Ji Young ; Park, Cheol Wan ; Liu, Yanna ; Kwon, Daeun ; Park, Seong Hyun ; Park, Sungjin ; Pai, Jaeyoung ; Shin, Injae. / Carbohydrate Analogue Microarrays for Identification of Lectin-Selective Ligands. In: ChemBioChem. 2017 ; Vol. 18, No. 12. pp. 1077-1082.
@article{3cf2980121684c58afd4e6b6a5911aa6,
title = "Carbohydrate Analogue Microarrays for Identification of Lectin-Selective Ligands",
abstract = "Fifty-five mono- and disaccharide analogues were prepared and used for the construction of microarrays to uncover lectin-selective ligands. The microarray study showed that two disaccharide analogues, 28′ and 44′, selectively bind to Solanum tuberosum lectin (STL) and wheat germ agglutinin (WGA), respectively. Cell studies indicated that 28′ and 44′ selectively block the binding of STL and WGA to mammalian cells, unlike the natural ligand LacNAc, which suppresses binding of both STL and WGA to cells.",
author = "Hyun, {Ji Young} and Park, {Cheol Wan} and Yanna Liu and Daeun Kwon and Park, {Seong Hyun} and Sungjin Park and Jaeyoung Pai and Injae Shin",
year = "2017",
month = "6",
day = "19",
doi = "10.1002/cbic.201700091",
language = "English",
volume = "18",
pages = "1077--1082",
journal = "ChemBioChem",
issn = "1439-4227",
publisher = "Wiley-VCH Verlag",
number = "12",

}

Hyun, JY, Park, CW, Liu, Y, Kwon, D, Park, SH, Park, S, Pai, J & Shin, I 2017, 'Carbohydrate Analogue Microarrays for Identification of Lectin-Selective Ligands', ChemBioChem, vol. 18, no. 12, pp. 1077-1082. https://doi.org/10.1002/cbic.201700091

Carbohydrate Analogue Microarrays for Identification of Lectin-Selective Ligands. / Hyun, Ji Young; Park, Cheol Wan; Liu, Yanna; Kwon, Daeun; Park, Seong Hyun; Park, Sungjin; Pai, Jaeyoung; Shin, Injae.

In: ChemBioChem, Vol. 18, No. 12, 19.06.2017, p. 1077-1082.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Carbohydrate Analogue Microarrays for Identification of Lectin-Selective Ligands

AU - Hyun, Ji Young

AU - Park, Cheol Wan

AU - Liu, Yanna

AU - Kwon, Daeun

AU - Park, Seong Hyun

AU - Park, Sungjin

AU - Pai, Jaeyoung

AU - Shin, Injae

PY - 2017/6/19

Y1 - 2017/6/19

N2 - Fifty-five mono- and disaccharide analogues were prepared and used for the construction of microarrays to uncover lectin-selective ligands. The microarray study showed that two disaccharide analogues, 28′ and 44′, selectively bind to Solanum tuberosum lectin (STL) and wheat germ agglutinin (WGA), respectively. Cell studies indicated that 28′ and 44′ selectively block the binding of STL and WGA to mammalian cells, unlike the natural ligand LacNAc, which suppresses binding of both STL and WGA to cells.

AB - Fifty-five mono- and disaccharide analogues were prepared and used for the construction of microarrays to uncover lectin-selective ligands. The microarray study showed that two disaccharide analogues, 28′ and 44′, selectively bind to Solanum tuberosum lectin (STL) and wheat germ agglutinin (WGA), respectively. Cell studies indicated that 28′ and 44′ selectively block the binding of STL and WGA to mammalian cells, unlike the natural ligand LacNAc, which suppresses binding of both STL and WGA to cells.

UR - http://www.scopus.com/inward/record.url?scp=85019220157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019220157&partnerID=8YFLogxK

U2 - 10.1002/cbic.201700091

DO - 10.1002/cbic.201700091

M3 - Article

C2 - 28422419

AN - SCOPUS:85019220157

VL - 18

SP - 1077

EP - 1082

JO - ChemBioChem

JF - ChemBioChem

SN - 1439-4227

IS - 12

ER -

Hyun JY, Park CW, Liu Y, Kwon D, Park SH, Park S et al. Carbohydrate Analogue Microarrays for Identification of Lectin-Selective Ligands. ChemBioChem. 2017 Jun 19;18(12):1077-1082. https://doi.org/10.1002/cbic.201700091