Carbohydrate Analogue Microarrays for Identification of Lectin-Selective Ligands

Ji Young Hyun, Cheol Wan Park, Yanna Liu, Daeun Kwon, Seong Hyun Park, Sungjin Park, Jaeyoung Pai, Injae Shin

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6 Citations (Scopus)

Abstract

Fifty-five mono- and disaccharide analogues were prepared and used for the construction of microarrays to uncover lectin-selective ligands. The microarray study showed that two disaccharide analogues, 28′ and 44′, selectively bind to Solanum tuberosum lectin (STL) and wheat germ agglutinin (WGA), respectively. Cell studies indicated that 28′ and 44′ selectively block the binding of STL and WGA to mammalian cells, unlike the natural ligand LacNAc, which suppresses binding of both STL and WGA to cells.

Original languageEnglish
Pages (from-to)1077-1082
Number of pages6
JournalChemBioChem
Volume18
Issue number12
DOIs
Publication statusPublished - 2017 Jun 19

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

Cite this

Hyun, J. Y., Park, C. W., Liu, Y., Kwon, D., Park, S. H., Park, S., Pai, J., & Shin, I. (2017). Carbohydrate Analogue Microarrays for Identification of Lectin-Selective Ligands. ChemBioChem, 18(12), 1077-1082. https://doi.org/10.1002/cbic.201700091