Carbohydrate Analogue Microarrays for Identification of Lectin-Selective Ligands

Ji Young Hyun; Cheol Wan Park; Yanna Liu; Daeun Kwon; Seong Hyun Park; Sungjin Park; Jaeyoung Pai; Injae Shin

doi:10.1002/cbic.201700091

Carbohydrate Analogue Microarrays for Identification of Lectin-Selective Ligands

Ji Young Hyun, Cheol Wan Park, Yanna Liu, Daeun Kwon, Seong Hyun Park, Sungjin Park, Jaeyoung Pai, Injae Shin

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Fifty-five mono- and disaccharide analogues were prepared and used for the construction of microarrays to uncover lectin-selective ligands. The microarray study showed that two disaccharide analogues, 28′ and 44′, selectively bind to Solanum tuberosum lectin (STL) and wheat germ agglutinin (WGA), respectively. Cell studies indicated that 28′ and 44′ selectively block the binding of STL and WGA to mammalian cells, unlike the natural ligand LacNAc, which suppresses binding of both STL and WGA to cells.

Original language	English
Pages (from-to)	1077-1082
Number of pages	6
Journal	ChemBioChem
Volume	18
Issue number	12
DOIs	https://doi.org/10.1002/cbic.201700091
Publication status	Published - 2017 Jun 19

Bibliographical note

Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

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abstract = "Fifty-five mono- and disaccharide analogues were prepared and used for the construction of microarrays to uncover lectin-selective ligands. The microarray study showed that two disaccharide analogues, 28′ and 44′, selectively bind to Solanum tuberosum lectin (STL) and wheat germ agglutinin (WGA), respectively. Cell studies indicated that 28′ and 44′ selectively block the binding of STL and WGA to mammalian cells, unlike the natural ligand LacNAc, which suppresses binding of both STL and WGA to cells.",

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AU - Park, Cheol Wan

AU - Liu, Yanna

AU - Kwon, Daeun

AU - Park, Seong Hyun

AU - Park, Sungjin

AU - Pai, Jaeyoung

AU - Shin, Injae

PY - 2017/6/19

Y1 - 2017/6/19

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AB - Fifty-five mono- and disaccharide analogues were prepared and used for the construction of microarrays to uncover lectin-selective ligands. The microarray study showed that two disaccharide analogues, 28′ and 44′, selectively bind to Solanum tuberosum lectin (STL) and wheat germ agglutinin (WGA), respectively. Cell studies indicated that 28′ and 44′ selectively block the binding of STL and WGA to mammalian cells, unlike the natural ligand LacNAc, which suppresses binding of both STL and WGA to cells.

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Carbohydrate Analogue Microarrays for Identification of Lectin-Selective Ligands

Abstract

Bibliographical note

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