Abstract
Triblock rigid-flexible dendritic block molecules consisting of a rigid aromatic segment as a stem segment, carbohydrate-branched dendrons as a flexible head, and a hydrophobic alkyl chain were synthesized and characterized. The carbohydrate conjugate molecule based on a methyl group as a hydrophobic tail, in the solid state, self-assembles into a 1D nanostructure, whereas the molecule based on a longer hydrophobic tail self-assembles into 2D nanosheets, as confirmed by X-ray scatterings. In aqueous solution, however, both molecules were observed to self-assemble into carbohydrate-coated cylindrical aggregates with a uniform diameter, as confirmed by dynamic light scatterings and transmission electron microscopic (TEM) investigations. Notably, these cylindrical objects reversibly transformed into spherical objects on addition of guest molecules. Investigation of the interactions of the carbohydrate-coated nanostructures with E. coli cells showed that both nano-objects could immobilize bacterial cells, while the degrees of immobilization were significantly dependent on the shape of nanostructure. These results demonstrated that the supramolecular materials that are responsive to external stimuli can provide novel opportunities to control many biological activities.
| Original language | English |
|---|---|
| Pages (from-to) | 4808-4814 |
| Number of pages | 7 |
| Journal | Journal of the American Chemical Society |
| Volume | 129 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 2007 Apr 18 |
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All Science Journal Classification (ASJC) codes
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry
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Carbohydrate-coated supramolecular structures : Transformation of nanofibers into spherical micelles triggered by guest encapsulation. / Ryu, Ja Hyoung; Lee, Eunji; Lim, Yong Beom; Lee, Myongsoo.
In: Journal of the American Chemical Society, Vol. 129, No. 15, 18.04.2007, p. 4808-4814.Research output: Contribution to journal › Article
TY - JOUR
T1 - Carbohydrate-coated supramolecular structures
T2 - Transformation of nanofibers into spherical micelles triggered by guest encapsulation
AU - Ryu, Ja Hyoung
AU - Lee, Eunji
AU - Lim, Yong Beom
AU - Lee, Myongsoo
PY - 2007/4/18
Y1 - 2007/4/18
N2 - Triblock rigid-flexible dendritic block molecules consisting of a rigid aromatic segment as a stem segment, carbohydrate-branched dendrons as a flexible head, and a hydrophobic alkyl chain were synthesized and characterized. The carbohydrate conjugate molecule based on a methyl group as a hydrophobic tail, in the solid state, self-assembles into a 1D nanostructure, whereas the molecule based on a longer hydrophobic tail self-assembles into 2D nanosheets, as confirmed by X-ray scatterings. In aqueous solution, however, both molecules were observed to self-assemble into carbohydrate-coated cylindrical aggregates with a uniform diameter, as confirmed by dynamic light scatterings and transmission electron microscopic (TEM) investigations. Notably, these cylindrical objects reversibly transformed into spherical objects on addition of guest molecules. Investigation of the interactions of the carbohydrate-coated nanostructures with E. coli cells showed that both nano-objects could immobilize bacterial cells, while the degrees of immobilization were significantly dependent on the shape of nanostructure. These results demonstrated that the supramolecular materials that are responsive to external stimuli can provide novel opportunities to control many biological activities.
AB - Triblock rigid-flexible dendritic block molecules consisting of a rigid aromatic segment as a stem segment, carbohydrate-branched dendrons as a flexible head, and a hydrophobic alkyl chain were synthesized and characterized. The carbohydrate conjugate molecule based on a methyl group as a hydrophobic tail, in the solid state, self-assembles into a 1D nanostructure, whereas the molecule based on a longer hydrophobic tail self-assembles into 2D nanosheets, as confirmed by X-ray scatterings. In aqueous solution, however, both molecules were observed to self-assemble into carbohydrate-coated cylindrical aggregates with a uniform diameter, as confirmed by dynamic light scatterings and transmission electron microscopic (TEM) investigations. Notably, these cylindrical objects reversibly transformed into spherical objects on addition of guest molecules. Investigation of the interactions of the carbohydrate-coated nanostructures with E. coli cells showed that both nano-objects could immobilize bacterial cells, while the degrees of immobilization were significantly dependent on the shape of nanostructure. These results demonstrated that the supramolecular materials that are responsive to external stimuli can provide novel opportunities to control many biological activities.
UR - http://www.scopus.com/inward/record.url?scp=34247481360&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247481360&partnerID=8YFLogxK
U2 - 10.1021/ja070173p
DO - 10.1021/ja070173p
M3 - Article
C2 - 17381095
AN - SCOPUS:34247481360
VL - 129
SP - 4808
EP - 4814
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 15
ER -