Carbohydrate microarrays

Sungjin Park, Jeffrey C. Gildersleeve, Ola Blixt, Injae Shin

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171 Citations (Scopus)

Abstract

In the last decade, carbohydrate microarrays have been core technologies for analyzing carbohydrate-mediated recognition events in a high-throughput fashion. A number of methods have been exploited for immobilizing glycans on the solid surface in a microarray format. This microarray-based technology has been widely employed for rapid analysis of the glycan binding properties of lectins and antibodies, the quantitative measurements of glycan–protein interactions, detection of cells and pathogens, identification of disease-related anti-glycan antibodies for diagnosis, and fast assessment of substrate specificities of glycosyltransferases. This review covers the construction of carbohydrate microarrays, detection methods of carbohydrate microarrays and their applications in biological and biomedical research.

Original languageEnglish
Pages (from-to)4310-4326
Number of pages17
JournalChemical Society reviews
Volume42
Issue number10
DOIs
Publication statusPublished - 2013 Apr 29

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Park, S., Gildersleeve, J. C., Blixt, O., & Shin, I. (2013). Carbohydrate microarrays. Chemical Society reviews, 42(10), 4310-4326. https://doi.org/10.1039/c2cs35401b