Carbon nanotube-based biosensor for detection hepatitis B

Jeseung Oh; Seunghwan Yoo; Young Wook Chang; Kookjin Lim; Kyung Hwa Yoo

doi:10.1016/j.cap.2009.06.045

Carbon nanotube-based biosensor for detection hepatitis B

Jeseung Oh, Seunghwan Yoo, Young Wook Chang, Kookjin Lim, Kyung Hwa Yoo

Department of Physics

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

We have fabricated carbon nanotube (CNT)-based biosensor with a field-effect transistor structure for detection of hepatitis B. For real-time measurement, a microfluidic channel was mounted on the device and the presence of hepatitis B antigen was detected by measuring the electrical conductance as a function of time. When hepatitis B antigen was exposed to the CNT biosensor with hepatitis B antibody immobilized, the conductance increased and then became nearly constant within 10 min. As the antigen concentration increases, the conductance increased further. These results demonstrate that hepatitis B is possibly detected in real-time using the CNT biosensor.

Original language	English
Pages (from-to)	e229-e231
Journal	Current Applied Physics
Volume	9
Issue number	4 SUPPL.
DOIs	https://doi.org/10.1016/j.cap.2009.06.045
Publication status	Published - 2009 Jul

Bibliographical note

Funding Information:
This work has been financially supported by Korea Science and Engineering Foundation through National Core Research Center for Nanomedical Technology (Grant No. R15-20040924-00000-0).

All Science Journal Classification (ASJC) codes

Materials Science(all)
Physics and Astronomy(all)

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title = "Carbon nanotube-based biosensor for detection hepatitis B",

abstract = "We have fabricated carbon nanotube (CNT)-based biosensor with a field-effect transistor structure for detection of hepatitis B. For real-time measurement, a microfluidic channel was mounted on the device and the presence of hepatitis B antigen was detected by measuring the electrical conductance as a function of time. When hepatitis B antigen was exposed to the CNT biosensor with hepatitis B antibody immobilized, the conductance increased and then became nearly constant within 10 min. As the antigen concentration increases, the conductance increased further. These results demonstrate that hepatitis B is possibly detected in real-time using the CNT biosensor.",

author = "Jeseung Oh and Seunghwan Yoo and Chang, {Young Wook} and Kookjin Lim and Yoo, {Kyung Hwa}",

note = "Funding Information: This work has been financially supported by Korea Science and Engineering Foundation through National Core Research Center for Nanomedical Technology (Grant No. R15-20040924-00000-0).",

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T1 - Carbon nanotube-based biosensor for detection hepatitis B

AU - Oh, Jeseung

AU - Yoo, Seunghwan

AU - Chang, Young Wook

AU - Lim, Kookjin

AU - Yoo, Kyung Hwa

N1 - Funding Information: This work has been financially supported by Korea Science and Engineering Foundation through National Core Research Center for Nanomedical Technology (Grant No. R15-20040924-00000-0).

PY - 2009/7

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N2 - We have fabricated carbon nanotube (CNT)-based biosensor with a field-effect transistor structure for detection of hepatitis B. For real-time measurement, a microfluidic channel was mounted on the device and the presence of hepatitis B antigen was detected by measuring the electrical conductance as a function of time. When hepatitis B antigen was exposed to the CNT biosensor with hepatitis B antibody immobilized, the conductance increased and then became nearly constant within 10 min. As the antigen concentration increases, the conductance increased further. These results demonstrate that hepatitis B is possibly detected in real-time using the CNT biosensor.

AB - We have fabricated carbon nanotube (CNT)-based biosensor with a field-effect transistor structure for detection of hepatitis B. For real-time measurement, a microfluidic channel was mounted on the device and the presence of hepatitis B antigen was detected by measuring the electrical conductance as a function of time. When hepatitis B antigen was exposed to the CNT biosensor with hepatitis B antibody immobilized, the conductance increased and then became nearly constant within 10 min. As the antigen concentration increases, the conductance increased further. These results demonstrate that hepatitis B is possibly detected in real-time using the CNT biosensor.

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