Carbon nanotube-based biosensor for detection of matrix metallopeptidase-9 and S-100B

Hyoung Sub Lee, Je Seung Oh, Young Wook Chang, Yoon Jung Park, Jeon Soo Shin, Kyung-hwa Yoo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We fabricated carbon nanotube (CNT)-based biosensor with field effect transistor structure for detection of matrix metallopeptidase-9 (MMP-9) and S-100B. To minimize contact effects, the metal electrodes were passivated with SiOx film, and anti-MMP-9 and S-100B antibody were immobilized on the CNT surface using a chemical linker. When MMP-9 or S-100B antigen was added to bind anti-MMP-9 or S-100B antibody, the decrease in electrical conductance was observed. We have also investigated the dependence of MMP-9 and S-100B concentration on the conductance change. A linear relationship was found between the conductance and the concentration in semi-logarithm scale.

Original languageEnglish
JournalCurrent Applied Physics
Volume9
Issue number4 SUPPL.
DOIs
Publication statusPublished - 2009 Jul 1

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Carbon Nanotubes
Metalloproteases
bioinstrumentation
Biosensors
Carbon nanotubes
carbon nanotubes
matrices
antibodies
Antibodies
antigens
Antigens
Field effect transistors
logarithms
field effect transistors
Metals
Electrodes
electrodes
metals

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Physics and Astronomy(all)

Cite this

Lee, Hyoung Sub ; Oh, Je Seung ; Chang, Young Wook ; Park, Yoon Jung ; Shin, Jeon Soo ; Yoo, Kyung-hwa. / Carbon nanotube-based biosensor for detection of matrix metallopeptidase-9 and S-100B. In: Current Applied Physics. 2009 ; Vol. 9, No. 4 SUPPL.
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Carbon nanotube-based biosensor for detection of matrix metallopeptidase-9 and S-100B. / Lee, Hyoung Sub; Oh, Je Seung; Chang, Young Wook; Park, Yoon Jung; Shin, Jeon Soo; Yoo, Kyung-hwa.

In: Current Applied Physics, Vol. 9, No. 4 SUPPL., 01.07.2009.

Research output: Contribution to journalArticle

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T1 - Carbon nanotube-based biosensor for detection of matrix metallopeptidase-9 and S-100B

AU - Lee, Hyoung Sub

AU - Oh, Je Seung

AU - Chang, Young Wook

AU - Park, Yoon Jung

AU - Shin, Jeon Soo

AU - Yoo, Kyung-hwa

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AB - We fabricated carbon nanotube (CNT)-based biosensor with field effect transistor structure for detection of matrix metallopeptidase-9 (MMP-9) and S-100B. To minimize contact effects, the metal electrodes were passivated with SiOx film, and anti-MMP-9 and S-100B antibody were immobilized on the CNT surface using a chemical linker. When MMP-9 or S-100B antigen was added to bind anti-MMP-9 or S-100B antibody, the decrease in electrical conductance was observed. We have also investigated the dependence of MMP-9 and S-100B concentration on the conductance change. A linear relationship was found between the conductance and the concentration in semi-logarithm scale.

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