Abstract
In this work, the synergy of one mature example from "lab-on-chip" domain, such as CE microchips with emerging miniaturized carbon nanotube detectors in analytical science, is presented. Two different carbon electrodes (glassy carbon electrode (GCE) 3 mm diameter, and screen-printed electrode (SPE) 0.3 mm × 2.5 mm) were modified with multiwalled carbon nanotubes (MWCNTs) and their electrochemical behavior was evaluated as detectors in CE microchip using water-soluble vitamins (pyridoxine, ascorbic acid, and folic acid) in pharmaceutical preparations as representative examples. The SPE modified with MWCNT was the best electrode for the vitamin analysis in terms of analytical performance. In addition, accurate determination of the three vitamins in four different pharmaceuticals was obtained (systematic error less than 9%) in only 400 s using a protocol that combined the sample analysis and the methodological calibration.
| Original language | English |
|---|---|
| Pages (from-to) | 2997-3004 |
| Number of pages | 8 |
| Journal | Electrophoresis |
| Volume | 29 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - 2008 Jul 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry
- Clinical Biochemistry
Cite this
}
Carbon nanotube disposable detectors in microchip capillary electrophoresis for water-soluble vitamin determination : Analytical possibilities in pharmaceutical quality control. / Crevillén, Agustín G.; Pumera, Martin; González, María Cristina; Escarpa, Alberto.
In: Electrophoresis, Vol. 29, No. 14, 01.07.2008, p. 2997-3004.Research output: Contribution to journal › Article
TY - JOUR
T1 - Carbon nanotube disposable detectors in microchip capillary electrophoresis for water-soluble vitamin determination
T2 - Analytical possibilities in pharmaceutical quality control
AU - Crevillén, Agustín G.
AU - Pumera, Martin
AU - González, María Cristina
AU - Escarpa, Alberto
PY - 2008/7/1
Y1 - 2008/7/1
N2 - In this work, the synergy of one mature example from "lab-on-chip" domain, such as CE microchips with emerging miniaturized carbon nanotube detectors in analytical science, is presented. Two different carbon electrodes (glassy carbon electrode (GCE) 3 mm diameter, and screen-printed electrode (SPE) 0.3 mm × 2.5 mm) were modified with multiwalled carbon nanotubes (MWCNTs) and their electrochemical behavior was evaluated as detectors in CE microchip using water-soluble vitamins (pyridoxine, ascorbic acid, and folic acid) in pharmaceutical preparations as representative examples. The SPE modified with MWCNT was the best electrode for the vitamin analysis in terms of analytical performance. In addition, accurate determination of the three vitamins in four different pharmaceuticals was obtained (systematic error less than 9%) in only 400 s using a protocol that combined the sample analysis and the methodological calibration.
AB - In this work, the synergy of one mature example from "lab-on-chip" domain, such as CE microchips with emerging miniaturized carbon nanotube detectors in analytical science, is presented. Two different carbon electrodes (glassy carbon electrode (GCE) 3 mm diameter, and screen-printed electrode (SPE) 0.3 mm × 2.5 mm) were modified with multiwalled carbon nanotubes (MWCNTs) and their electrochemical behavior was evaluated as detectors in CE microchip using water-soluble vitamins (pyridoxine, ascorbic acid, and folic acid) in pharmaceutical preparations as representative examples. The SPE modified with MWCNT was the best electrode for the vitamin analysis in terms of analytical performance. In addition, accurate determination of the three vitamins in four different pharmaceuticals was obtained (systematic error less than 9%) in only 400 s using a protocol that combined the sample analysis and the methodological calibration.
UR - http://www.scopus.com/inward/record.url?scp=48749085390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48749085390&partnerID=8YFLogxK
U2 - 10.1002/elps.200700947
DO - 10.1002/elps.200700947
M3 - Article
C2 - 18576364
AN - SCOPUS:48749085390
VL - 29
SP - 2997
EP - 3004
JO - Electrophoresis
JF - Electrophoresis
SN - 0173-0835
IS - 14
ER -