Carbon nanotube-patterned surface-based recognition of carcinoembryonic antigens in tumor cells for cancer diagnosis

Taeyun Kwon, Jinsung Park, Gyudo Lee, Kihwan Nam, Yong Min Huh, Seong Wook Lee, Jaemoon Yang, Chang Young Lee, Kilho Eom

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

It has been of high significance to devise a biochemical analytical tool kit enabling the detection of few circulating tumor cells (CTCs) for early diagnosis of cancer. Despite recent effort made to detect few CTCs, it is still challenging to sense such cells with their low concentration and/or the minute amount of marker proteins expressed on few CTCs. In this work, we report the label-free recognition of carcinoembryonic antigens (CEAs) expressed on few CTCs by using a carbon nanotube (CNT) sensor coupled with scanning probe microscopy imaging for cancer diagnosis. It is shown that a CNT-patterned surface is able to specifically capture the CEA molecules in the whole cell lysate of CTCs with their concentration even up to 10-3 cells/mL. Our work sheds light on our bioassay based on a CNT-patterned surface for highly sensitive, label-free detection of marker proteins expressed on few tumor cells, which may open a new avenue in early diagnosis of cancer by providing a novel biochemical analysis tool kit.

Original languageEnglish
Pages (from-to)1126-1130
Number of pages5
JournalJournal of Physical Chemistry Letters
Volume4
Issue number7
DOIs
Publication statusPublished - 2013 Apr 4

Fingerprint

Carbon Nanotubes
Carcinoembryonic Antigen
antigens
Antigens
Tumors
Carbon nanotubes
tumors
cancer
carbon nanotubes
Cells
kits
markers
Labels
cells
proteins
Proteins
Scanning probe microscopy
bioassay
Bioassay
low concentrations

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Physical and Theoretical Chemistry

Cite this

Kwon, Taeyun ; Park, Jinsung ; Lee, Gyudo ; Nam, Kihwan ; Huh, Yong Min ; Lee, Seong Wook ; Yang, Jaemoon ; Lee, Chang Young ; Eom, Kilho. / Carbon nanotube-patterned surface-based recognition of carcinoembryonic antigens in tumor cells for cancer diagnosis. In: Journal of Physical Chemistry Letters. 2013 ; Vol. 4, No. 7. pp. 1126-1130.
@article{c7929d97c80e4c35a7105b565ffd25b8,
title = "Carbon nanotube-patterned surface-based recognition of carcinoembryonic antigens in tumor cells for cancer diagnosis",
abstract = "It has been of high significance to devise a biochemical analytical tool kit enabling the detection of few circulating tumor cells (CTCs) for early diagnosis of cancer. Despite recent effort made to detect few CTCs, it is still challenging to sense such cells with their low concentration and/or the minute amount of marker proteins expressed on few CTCs. In this work, we report the label-free recognition of carcinoembryonic antigens (CEAs) expressed on few CTCs by using a carbon nanotube (CNT) sensor coupled with scanning probe microscopy imaging for cancer diagnosis. It is shown that a CNT-patterned surface is able to specifically capture the CEA molecules in the whole cell lysate of CTCs with their concentration even up to 10-3 cells/mL. Our work sheds light on our bioassay based on a CNT-patterned surface for highly sensitive, label-free detection of marker proteins expressed on few tumor cells, which may open a new avenue in early diagnosis of cancer by providing a novel biochemical analysis tool kit.",
author = "Taeyun Kwon and Jinsung Park and Gyudo Lee and Kihwan Nam and Huh, {Yong Min} and Lee, {Seong Wook} and Jaemoon Yang and Lee, {Chang Young} and Kilho Eom",
year = "2013",
month = "4",
day = "4",
doi = "10.1021/jz400087m",
language = "English",
volume = "4",
pages = "1126--1130",
journal = "Journal of Physical Chemistry Letters",
issn = "1948-7185",
publisher = "American Chemical Society",
number = "7",

}

Carbon nanotube-patterned surface-based recognition of carcinoembryonic antigens in tumor cells for cancer diagnosis. / Kwon, Taeyun; Park, Jinsung; Lee, Gyudo; Nam, Kihwan; Huh, Yong Min; Lee, Seong Wook; Yang, Jaemoon; Lee, Chang Young; Eom, Kilho.

In: Journal of Physical Chemistry Letters, Vol. 4, No. 7, 04.04.2013, p. 1126-1130.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Carbon nanotube-patterned surface-based recognition of carcinoembryonic antigens in tumor cells for cancer diagnosis

AU - Kwon, Taeyun

AU - Park, Jinsung

AU - Lee, Gyudo

AU - Nam, Kihwan

AU - Huh, Yong Min

AU - Lee, Seong Wook

AU - Yang, Jaemoon

AU - Lee, Chang Young

AU - Eom, Kilho

PY - 2013/4/4

Y1 - 2013/4/4

N2 - It has been of high significance to devise a biochemical analytical tool kit enabling the detection of few circulating tumor cells (CTCs) for early diagnosis of cancer. Despite recent effort made to detect few CTCs, it is still challenging to sense such cells with their low concentration and/or the minute amount of marker proteins expressed on few CTCs. In this work, we report the label-free recognition of carcinoembryonic antigens (CEAs) expressed on few CTCs by using a carbon nanotube (CNT) sensor coupled with scanning probe microscopy imaging for cancer diagnosis. It is shown that a CNT-patterned surface is able to specifically capture the CEA molecules in the whole cell lysate of CTCs with their concentration even up to 10-3 cells/mL. Our work sheds light on our bioassay based on a CNT-patterned surface for highly sensitive, label-free detection of marker proteins expressed on few tumor cells, which may open a new avenue in early diagnosis of cancer by providing a novel biochemical analysis tool kit.

AB - It has been of high significance to devise a biochemical analytical tool kit enabling the detection of few circulating tumor cells (CTCs) for early diagnosis of cancer. Despite recent effort made to detect few CTCs, it is still challenging to sense such cells with their low concentration and/or the minute amount of marker proteins expressed on few CTCs. In this work, we report the label-free recognition of carcinoembryonic antigens (CEAs) expressed on few CTCs by using a carbon nanotube (CNT) sensor coupled with scanning probe microscopy imaging for cancer diagnosis. It is shown that a CNT-patterned surface is able to specifically capture the CEA molecules in the whole cell lysate of CTCs with their concentration even up to 10-3 cells/mL. Our work sheds light on our bioassay based on a CNT-patterned surface for highly sensitive, label-free detection of marker proteins expressed on few tumor cells, which may open a new avenue in early diagnosis of cancer by providing a novel biochemical analysis tool kit.

UR - http://www.scopus.com/inward/record.url?scp=84875798921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875798921&partnerID=8YFLogxK

U2 - 10.1021/jz400087m

DO - 10.1021/jz400087m

M3 - Article

AN - SCOPUS:84875798921

VL - 4

SP - 1126

EP - 1130

JO - Journal of Physical Chemistry Letters

JF - Journal of Physical Chemistry Letters

SN - 1948-7185

IS - 7

ER -