Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats

Wan Seob Cho, Beom Seok Han, Ki Taek Nam, Kidae Park, Mina Choi, Seung Hee Kim, Jayoung Jeong, Dong Deuk Jang

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Abstract

3-Monochloropropane-1,2-diol (α-chlorohydrin, 3-MCPD) is a well-known contaminant, which has been detected in a wide range of foods and ingredients, and is also a suspected cause of cancer. In this study, the carcinogenicity of 3-MCPD in SD rats was investigated. Groups of 50 male and 50 female rats were exposed for two years to drinking water containing 0, 25, 100 or 400 ppm 3-MCPD. The body weights and water consumptions of the male and female rats given 400 ppm 3-MCPD were significantly lower than those of the controls. The incidences of renal tubule adenomas or carcinomas and Leydig cell tumors occurred with dose-related positive trends in male rats. The incidences of renal tubule carcinomas and Leydig cell tumors were significantly increased in male rats given 400 ppm 3-MCPD. The incidence of renal tubule adenomas showed a positive trend in female rats, which was significant in 400 ppm 3-MCPD group. In conclusion, there was clear evidence of the carcinogenic activity of 3-MCPD in male SD rats, based on the increased incidences of renal tubule carcinomas and Leydig cell tumors. There was some evidence of the carcinogenic activity of 3-MCPD in female SD rats, based on the increased incidence of renal tubule adenomas.

Original languageEnglish
Pages (from-to)3172-3177
Number of pages6
JournalFood and Chemical Toxicology
Volume46
Issue number9
DOIs
Publication statusPublished - 2008 Sep 1

Fingerprint

alpha-Chlorohydrin
carcinogenicity
Sprague Dawley Rats
Rats
renal tubules
rats
Leydig Cell Tumor
Leydig cells
adenoma
Kidney
incidence
Adenoma
Incidence
carcinoma
Tumors
neoplasms
Carcinoma
Chlorohydrins
alpha-chlorohydrin
Body Water

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

Cite this

Cho, Wan Seob ; Han, Beom Seok ; Nam, Ki Taek ; Park, Kidae ; Choi, Mina ; Kim, Seung Hee ; Jeong, Jayoung ; Jang, Dong Deuk. / Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats. In: Food and Chemical Toxicology. 2008 ; Vol. 46, No. 9. pp. 3172-3177.
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abstract = "3-Monochloropropane-1,2-diol (α-chlorohydrin, 3-MCPD) is a well-known contaminant, which has been detected in a wide range of foods and ingredients, and is also a suspected cause of cancer. In this study, the carcinogenicity of 3-MCPD in SD rats was investigated. Groups of 50 male and 50 female rats were exposed for two years to drinking water containing 0, 25, 100 or 400 ppm 3-MCPD. The body weights and water consumptions of the male and female rats given 400 ppm 3-MCPD were significantly lower than those of the controls. The incidences of renal tubule adenomas or carcinomas and Leydig cell tumors occurred with dose-related positive trends in male rats. The incidences of renal tubule carcinomas and Leydig cell tumors were significantly increased in male rats given 400 ppm 3-MCPD. The incidence of renal tubule adenomas showed a positive trend in female rats, which was significant in 400 ppm 3-MCPD group. In conclusion, there was clear evidence of the carcinogenic activity of 3-MCPD in male SD rats, based on the increased incidences of renal tubule carcinomas and Leydig cell tumors. There was some evidence of the carcinogenic activity of 3-MCPD in female SD rats, based on the increased incidence of renal tubule adenomas.",
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Cho, WS, Han, BS, Nam, KT, Park, K, Choi, M, Kim, SH, Jeong, J & Jang, DD 2008, 'Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats', Food and Chemical Toxicology, vol. 46, no. 9, pp. 3172-3177. https://doi.org/10.1016/j.fct.2008.07.003

Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats. / Cho, Wan Seob; Han, Beom Seok; Nam, Ki Taek; Park, Kidae; Choi, Mina; Kim, Seung Hee; Jeong, Jayoung; Jang, Dong Deuk.

In: Food and Chemical Toxicology, Vol. 46, No. 9, 01.09.2008, p. 3172-3177.

Research output: Contribution to journalArticle

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T1 - Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats

AU - Cho, Wan Seob

AU - Han, Beom Seok

AU - Nam, Ki Taek

AU - Park, Kidae

AU - Choi, Mina

AU - Kim, Seung Hee

AU - Jeong, Jayoung

AU - Jang, Dong Deuk

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N2 - 3-Monochloropropane-1,2-diol (α-chlorohydrin, 3-MCPD) is a well-known contaminant, which has been detected in a wide range of foods and ingredients, and is also a suspected cause of cancer. In this study, the carcinogenicity of 3-MCPD in SD rats was investigated. Groups of 50 male and 50 female rats were exposed for two years to drinking water containing 0, 25, 100 or 400 ppm 3-MCPD. The body weights and water consumptions of the male and female rats given 400 ppm 3-MCPD were significantly lower than those of the controls. The incidences of renal tubule adenomas or carcinomas and Leydig cell tumors occurred with dose-related positive trends in male rats. The incidences of renal tubule carcinomas and Leydig cell tumors were significantly increased in male rats given 400 ppm 3-MCPD. The incidence of renal tubule adenomas showed a positive trend in female rats, which was significant in 400 ppm 3-MCPD group. In conclusion, there was clear evidence of the carcinogenic activity of 3-MCPD in male SD rats, based on the increased incidences of renal tubule carcinomas and Leydig cell tumors. There was some evidence of the carcinogenic activity of 3-MCPD in female SD rats, based on the increased incidence of renal tubule adenomas.

AB - 3-Monochloropropane-1,2-diol (α-chlorohydrin, 3-MCPD) is a well-known contaminant, which has been detected in a wide range of foods and ingredients, and is also a suspected cause of cancer. In this study, the carcinogenicity of 3-MCPD in SD rats was investigated. Groups of 50 male and 50 female rats were exposed for two years to drinking water containing 0, 25, 100 or 400 ppm 3-MCPD. The body weights and water consumptions of the male and female rats given 400 ppm 3-MCPD were significantly lower than those of the controls. The incidences of renal tubule adenomas or carcinomas and Leydig cell tumors occurred with dose-related positive trends in male rats. The incidences of renal tubule carcinomas and Leydig cell tumors were significantly increased in male rats given 400 ppm 3-MCPD. The incidence of renal tubule adenomas showed a positive trend in female rats, which was significant in 400 ppm 3-MCPD group. In conclusion, there was clear evidence of the carcinogenic activity of 3-MCPD in male SD rats, based on the increased incidences of renal tubule carcinomas and Leydig cell tumors. There was some evidence of the carcinogenic activity of 3-MCPD in female SD rats, based on the increased incidence of renal tubule adenomas.

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