Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats

Wan Seob Cho, Beom Seok Han, Ki Taek Nam, Kidae Park, Mina Choi, Seung Hee Kim, Jayoung Jeong, Dong Deuk Jang

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101 Citations (Scopus)

Abstract

3-Monochloropropane-1,2-diol (α-chlorohydrin, 3-MCPD) is a well-known contaminant, which has been detected in a wide range of foods and ingredients, and is also a suspected cause of cancer. In this study, the carcinogenicity of 3-MCPD in SD rats was investigated. Groups of 50 male and 50 female rats were exposed for two years to drinking water containing 0, 25, 100 or 400 ppm 3-MCPD. The body weights and water consumptions of the male and female rats given 400 ppm 3-MCPD were significantly lower than those of the controls. The incidences of renal tubule adenomas or carcinomas and Leydig cell tumors occurred with dose-related positive trends in male rats. The incidences of renal tubule carcinomas and Leydig cell tumors were significantly increased in male rats given 400 ppm 3-MCPD. The incidence of renal tubule adenomas showed a positive trend in female rats, which was significant in 400 ppm 3-MCPD group. In conclusion, there was clear evidence of the carcinogenic activity of 3-MCPD in male SD rats, based on the increased incidences of renal tubule carcinomas and Leydig cell tumors. There was some evidence of the carcinogenic activity of 3-MCPD in female SD rats, based on the increased incidence of renal tubule adenomas.

Original languageEnglish
Pages (from-to)3172-3177
Number of pages6
JournalFood and Chemical Toxicology
Volume46
Issue number9
DOIs
Publication statusPublished - 2008 Sep

Bibliographical note

Funding Information:
This research was supported by a Grant (05121KFDA455) from Korea Food and Drug Administration from 2002 to 2005.

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

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