Cardiac magnetic resonance imaging-derived pulmonary artery distensibility index correlates with pulmonary artery stiffness and predicts functional capacity in patients with pulmonary arterial hypertension

Ki Woon Kang, Hyuk Jae Chang, Young Jin Kim, Byoung Wook Choi, Hye Sun Lee, Woo In Yang, Chi Young Shim, Jongwon Ha, Namsik Chung

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Increased stiffness of the pulmonary vascular bed is known to increase mortality in patients with pulmonary arterial hypertension (PAH); and pulmonary artery (PA) stiffness is also thought to be associated with exercise capacity. The purpose of the present study was to investigate whether cardiac magnetic resonance imaging (CMRI)-derived PA distensibility index correlates with PA stiffness estimated on right heart catheterization (RHC) and predicts functional capacity (FC) in patients with PAH. Methods and Results: Thirty-five consecutive PAH patients (23% male, mean age, 44±13 years; 69% idiopathic) underwent CMRI, RHC, and 6-min walk test (6MWT). PA distensibility indices were derived from cross-sectional area change (%) in the transverse view, perpendicular to the axis of the main PA, on CMRI [(maximum area-minimum area)/minimum area during cardiac cycle]. Among the PA stiffness indices, pulmonary vascular resistance (PVR) and PA capacitance were calculated using hemodynamic dataset from RHC. CMRI-derived PA distensibility was inversely correlated with PVR (R 2=0.34, P<0.001) and directly correlated with PA capacitance (R 2=0.35, P<0.001), and the distance in the 6MWT (R 2=0.61, P<0.001). Furthermore, PA distensibility <20% predicted poor FC (<400 m in 6MWT) with a sensitivity of 82% and a specificity of 94%. Conclusions: Non-invasive CMRI-derived PA distensibility index correlates with PA stiffness and can predict FC in patients with PAH.

Original languageEnglish
Pages (from-to)2244-2251
Number of pages8
JournalCirculation Journal
Volume75
Issue number9
DOIs
Publication statusPublished - 2011 Sep

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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