Cardiac [123I] metaiodobenzylguanidine scintigraphy for vascular Parkinsonism

Joong Seok Kim, philhyu Lee, Kwang Soo Lee, Jeong Wook Park, Yeong In Kim, Yong An Chung, Sung Hoon Kim, Seung Hyun Kim, Juhan Kim, Yun Young Choi, Hee Tae Kim

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Abstract

The purpose of our study was to prospectively evaluate cardiac [123I]metaiodobenzylguanidine (MIBG) uptake in patients with cerebrovascular disease (CVD) who develop clinical symptoms of vascular Parkinsonism (VP). A total of 19 consecutive patients who developed Parkinsonism during the course of their CVD were enrolled in the study; 15 age-matched subjects, and 29 patients with Parkinson's disease (PD) were also evaluated with cardiac MIBG uptake. MIBG uptake was assessed using the ratio of the heart to the upper mediastinum (H/M) according to planar scintigraphic data. The mean H/M ratio was significantly higher in patients with VP than in those with PD (2.28 ± 0.41 vs. 1.27 ± 0.13; P < 0.001). MIBG uptake did not differ between VP and controls (2.46 ± 0.33; P > 0.05). Our findings suggest that myocardial postganglionic sympathetic dysfunction found in PD is absent in most patients with VP. MIBG single photon emission computed tomography imaging may be useful to help distinguish between PD and VP patients in clinical practice.

Original languageEnglish
Pages (from-to)1990-1994
Number of pages5
JournalMovement Disorders
Volume21
Issue number11
DOIs
Publication statusPublished - 2006 Nov 1

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Parkinsonian Disorders
Radionuclide Imaging
Blood Vessels
Parkinson Disease
Cerebrovascular Disorders
Mediastinum
Single-Photon Emission-Computed Tomography

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Kim, J. S., Lee, P., Lee, K. S., Park, J. W., Kim, Y. I., Chung, Y. A., ... Kim, H. T. (2006). Cardiac [123I] metaiodobenzylguanidine scintigraphy for vascular Parkinsonism. Movement Disorders, 21(11), 1990-1994. https://doi.org/10.1002/mds.21112
Kim, Joong Seok ; Lee, philhyu ; Lee, Kwang Soo ; Park, Jeong Wook ; Kim, Yeong In ; Chung, Yong An ; Kim, Sung Hoon ; Kim, Seung Hyun ; Kim, Juhan ; Choi, Yun Young ; Kim, Hee Tae. / Cardiac [123I] metaiodobenzylguanidine scintigraphy for vascular Parkinsonism. In: Movement Disorders. 2006 ; Vol. 21, No. 11. pp. 1990-1994.
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Kim, JS, Lee, P, Lee, KS, Park, JW, Kim, YI, Chung, YA, Kim, SH, Kim, SH, Kim, J, Choi, YY & Kim, HT 2006, 'Cardiac [123I] metaiodobenzylguanidine scintigraphy for vascular Parkinsonism', Movement Disorders, vol. 21, no. 11, pp. 1990-1994. https://doi.org/10.1002/mds.21112

Cardiac [123I] metaiodobenzylguanidine scintigraphy for vascular Parkinsonism. / Kim, Joong Seok; Lee, philhyu; Lee, Kwang Soo; Park, Jeong Wook; Kim, Yeong In; Chung, Yong An; Kim, Sung Hoon; Kim, Seung Hyun; Kim, Juhan; Choi, Yun Young; Kim, Hee Tae.

In: Movement Disorders, Vol. 21, No. 11, 01.11.2006, p. 1990-1994.

Research output: Contribution to journalArticle

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AU - Kim, Joong Seok

AU - Lee, philhyu

AU - Lee, Kwang Soo

AU - Park, Jeong Wook

AU - Kim, Yeong In

AU - Chung, Yong An

AU - Kim, Sung Hoon

AU - Kim, Seung Hyun

AU - Kim, Juhan

AU - Choi, Yun Young

AU - Kim, Hee Tae

PY - 2006/11/1

Y1 - 2006/11/1

N2 - The purpose of our study was to prospectively evaluate cardiac [123I]metaiodobenzylguanidine (MIBG) uptake in patients with cerebrovascular disease (CVD) who develop clinical symptoms of vascular Parkinsonism (VP). A total of 19 consecutive patients who developed Parkinsonism during the course of their CVD were enrolled in the study; 15 age-matched subjects, and 29 patients with Parkinson's disease (PD) were also evaluated with cardiac MIBG uptake. MIBG uptake was assessed using the ratio of the heart to the upper mediastinum (H/M) according to planar scintigraphic data. The mean H/M ratio was significantly higher in patients with VP than in those with PD (2.28 ± 0.41 vs. 1.27 ± 0.13; P < 0.001). MIBG uptake did not differ between VP and controls (2.46 ± 0.33; P > 0.05). Our findings suggest that myocardial postganglionic sympathetic dysfunction found in PD is absent in most patients with VP. MIBG single photon emission computed tomography imaging may be useful to help distinguish between PD and VP patients in clinical practice.

AB - The purpose of our study was to prospectively evaluate cardiac [123I]metaiodobenzylguanidine (MIBG) uptake in patients with cerebrovascular disease (CVD) who develop clinical symptoms of vascular Parkinsonism (VP). A total of 19 consecutive patients who developed Parkinsonism during the course of their CVD were enrolled in the study; 15 age-matched subjects, and 29 patients with Parkinson's disease (PD) were also evaluated with cardiac MIBG uptake. MIBG uptake was assessed using the ratio of the heart to the upper mediastinum (H/M) according to planar scintigraphic data. The mean H/M ratio was significantly higher in patients with VP than in those with PD (2.28 ± 0.41 vs. 1.27 ± 0.13; P < 0.001). MIBG uptake did not differ between VP and controls (2.46 ± 0.33; P > 0.05). Our findings suggest that myocardial postganglionic sympathetic dysfunction found in PD is absent in most patients with VP. MIBG single photon emission computed tomography imaging may be useful to help distinguish between PD and VP patients in clinical practice.

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