Cardiac [123I] metaiodobenzylguanidine scintigraphy for vascular Parkinsonism

Joong Seok Kim, Phil Hyu Lee, Kwang Soo Lee, Jeong Wook Park, Yeong In Kim, Yong An Chung, Sung Hoon Kim, Seung Hyun Kim, Juhan Kim, Yun Young Choi, Hee Tae Kim

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Abstract

The purpose of our study was to prospectively evaluate cardiac [123I]metaiodobenzylguanidine (MIBG) uptake in patients with cerebrovascular disease (CVD) who develop clinical symptoms of vascular Parkinsonism (VP). A total of 19 consecutive patients who developed Parkinsonism during the course of their CVD were enrolled in the study; 15 age-matched subjects, and 29 patients with Parkinson's disease (PD) were also evaluated with cardiac MIBG uptake. MIBG uptake was assessed using the ratio of the heart to the upper mediastinum (H/M) according to planar scintigraphic data. The mean H/M ratio was significantly higher in patients with VP than in those with PD (2.28 ± 0.41 vs. 1.27 ± 0.13; P < 0.001). MIBG uptake did not differ between VP and controls (2.46 ± 0.33; P > 0.05). Our findings suggest that myocardial postganglionic sympathetic dysfunction found in PD is absent in most patients with VP. MIBG single photon emission computed tomography imaging may be useful to help distinguish between PD and VP patients in clinical practice.

Original languageEnglish
Pages (from-to)1990-1994
Number of pages5
JournalMovement Disorders
Volume21
Issue number11
DOIs
Publication statusPublished - 2006 Nov

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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    Kim, J. S., Lee, P. H., Lee, K. S., Park, J. W., Kim, Y. I., Chung, Y. A., Kim, S. H., Kim, S. H., Kim, J., Choi, Y. Y., & Kim, H. T. (2006). Cardiac [123I] metaiodobenzylguanidine scintigraphy for vascular Parkinsonism. Movement Disorders, 21(11), 1990-1994. https://doi.org/10.1002/mds.21112