Cardiopulmonary fitness, adiponectin, chemerin associated fasting insulin level in colorectal cancer patients

Ki Yong Ahn, Mi Kyung Lee, Dong Il Kim, Jihye Park, Jihee Min, Hyuk In Yang, Junga Lee, Minsuk Oh, Joongbae An, Ji Won Lee, Sang Hui Chu, Jeffrey A. Meyerhardt, Namkyu Kim, Justin Y. Jeon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Since circulating level of insulin is associated with colorectal cancer prognosis, it is important to identify factors contributing to fasting insulin level in colorectal cancer patients. The purpose of the current study is to investigate the association of physical fitness, adiponectin, and chemerin levels with circulating level of insulin in colorectal cancer patients. Methods: A total of 123 stage II-III colorectal cancer patients who completed standard cancer treatment were recruited. Anthropometric characteristics, fitness measurements, fasting insulin level, homeostasis model assessment of insulin resistance, lipid profiles, and adiponectin and chemerin levels were analyzed. Result: Cardiopulmonary fitness level inversely associated with fasting insulin levels (the least fit (1st tertile): 8.11 ± 0.64, moderately fit (2nd tertile): 6.02 ± 0.63, and highly fit (3rd tertile): 5.58 ± 0.66 μU/ml, unfit vs. moderately fit, p < 0.01; unfit vs. highly fit, p < 0.05) after adjustment for gender, age, stage, and BMI. In addition, fasting adiponectin and chemerin levels were associated with fasting insulin levels after adjustment for gender, age, stage, and BMI. In our combined analyses, participants with high adiponectin and low chemerin levels showed significantly lower fasting insulin levels (4.92 ± 0.75 vs. 8.07 ± 0.80 μU/ml, p < 0.01) compared with participants with low adiponectin and high chemerin levels. Multiple linear regression analysis confirmed that cardiopulmonary fitness and adiponectin levels (β = −0.299, p = 0.002; β = −0.201, p = 0.033) were independently associated with fasting insulin level. Conclusion: Our results suggest that physical fitness and adiponectin and chemerin levels may contribute to circulating levels of insulin. These results suggest that exercise may influence the prognosis of colorectal cancer patients by influencing physical fitness level, circulating levels of adiponectin and chemerin.

Original languageEnglish
Pages (from-to)2927-2935
Number of pages9
JournalSupportive Care in Cancer
Volume24
Issue number7
DOIs
Publication statusPublished - 2016 Jul 1

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Adiponectin
Colorectal Neoplasms
Fasting
Insulin
Physical Fitness
Insulin Resistance
Linear Models
Homeostasis
Regression Analysis
Exercise
Lipids

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Ahn, Ki Yong ; Lee, Mi Kyung ; Kim, Dong Il ; Park, Jihye ; Min, Jihee ; In Yang, Hyuk ; Lee, Junga ; Oh, Minsuk ; An, Joongbae ; Lee, Ji Won ; Chu, Sang Hui ; Meyerhardt, Jeffrey A. ; Kim, Namkyu ; Jeon, Justin Y. / Cardiopulmonary fitness, adiponectin, chemerin associated fasting insulin level in colorectal cancer patients. In: Supportive Care in Cancer. 2016 ; Vol. 24, No. 7. pp. 2927-2935.
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title = "Cardiopulmonary fitness, adiponectin, chemerin associated fasting insulin level in colorectal cancer patients",
abstract = "Purpose: Since circulating level of insulin is associated with colorectal cancer prognosis, it is important to identify factors contributing to fasting insulin level in colorectal cancer patients. The purpose of the current study is to investigate the association of physical fitness, adiponectin, and chemerin levels with circulating level of insulin in colorectal cancer patients. Methods: A total of 123 stage II-III colorectal cancer patients who completed standard cancer treatment were recruited. Anthropometric characteristics, fitness measurements, fasting insulin level, homeostasis model assessment of insulin resistance, lipid profiles, and adiponectin and chemerin levels were analyzed. Result: Cardiopulmonary fitness level inversely associated with fasting insulin levels (the least fit (1st tertile): 8.11 ± 0.64, moderately fit (2nd tertile): 6.02 ± 0.63, and highly fit (3rd tertile): 5.58 ± 0.66 μU/ml, unfit vs. moderately fit, p < 0.01; unfit vs. highly fit, p < 0.05) after adjustment for gender, age, stage, and BMI. In addition, fasting adiponectin and chemerin levels were associated with fasting insulin levels after adjustment for gender, age, stage, and BMI. In our combined analyses, participants with high adiponectin and low chemerin levels showed significantly lower fasting insulin levels (4.92 ± 0.75 vs. 8.07 ± 0.80 μU/ml, p < 0.01) compared with participants with low adiponectin and high chemerin levels. Multiple linear regression analysis confirmed that cardiopulmonary fitness and adiponectin levels (β = −0.299, p = 0.002; β = −0.201, p = 0.033) were independently associated with fasting insulin level. Conclusion: Our results suggest that physical fitness and adiponectin and chemerin levels may contribute to circulating levels of insulin. These results suggest that exercise may influence the prognosis of colorectal cancer patients by influencing physical fitness level, circulating levels of adiponectin and chemerin.",
author = "Ahn, {Ki Yong} and Lee, {Mi Kyung} and Kim, {Dong Il} and Jihye Park and Jihee Min and {In Yang}, Hyuk and Junga Lee and Minsuk Oh and Joongbae An and Lee, {Ji Won} and Chu, {Sang Hui} and Meyerhardt, {Jeffrey A.} and Namkyu Kim and Jeon, {Justin Y.}",
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Ahn, KY, Lee, MK, Kim, DI, Park, J, Min, J, In Yang, H, Lee, J, Oh, M, An, J, Lee, JW, Chu, SH, Meyerhardt, JA, Kim, N & Jeon, JY 2016, 'Cardiopulmonary fitness, adiponectin, chemerin associated fasting insulin level in colorectal cancer patients', Supportive Care in Cancer, vol. 24, no. 7, pp. 2927-2935. https://doi.org/10.1007/s00520-016-3095-4

Cardiopulmonary fitness, adiponectin, chemerin associated fasting insulin level in colorectal cancer patients. / Ahn, Ki Yong; Lee, Mi Kyung; Kim, Dong Il; Park, Jihye; Min, Jihee; In Yang, Hyuk; Lee, Junga; Oh, Minsuk; An, Joongbae; Lee, Ji Won; Chu, Sang Hui; Meyerhardt, Jeffrey A.; Kim, Namkyu; Jeon, Justin Y.

In: Supportive Care in Cancer, Vol. 24, No. 7, 01.07.2016, p. 2927-2935.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cardiopulmonary fitness, adiponectin, chemerin associated fasting insulin level in colorectal cancer patients

AU - Ahn, Ki Yong

AU - Lee, Mi Kyung

AU - Kim, Dong Il

AU - Park, Jihye

AU - Min, Jihee

AU - In Yang, Hyuk

AU - Lee, Junga

AU - Oh, Minsuk

AU - An, Joongbae

AU - Lee, Ji Won

AU - Chu, Sang Hui

AU - Meyerhardt, Jeffrey A.

AU - Kim, Namkyu

AU - Jeon, Justin Y.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Purpose: Since circulating level of insulin is associated with colorectal cancer prognosis, it is important to identify factors contributing to fasting insulin level in colorectal cancer patients. The purpose of the current study is to investigate the association of physical fitness, adiponectin, and chemerin levels with circulating level of insulin in colorectal cancer patients. Methods: A total of 123 stage II-III colorectal cancer patients who completed standard cancer treatment were recruited. Anthropometric characteristics, fitness measurements, fasting insulin level, homeostasis model assessment of insulin resistance, lipid profiles, and adiponectin and chemerin levels were analyzed. Result: Cardiopulmonary fitness level inversely associated with fasting insulin levels (the least fit (1st tertile): 8.11 ± 0.64, moderately fit (2nd tertile): 6.02 ± 0.63, and highly fit (3rd tertile): 5.58 ± 0.66 μU/ml, unfit vs. moderately fit, p < 0.01; unfit vs. highly fit, p < 0.05) after adjustment for gender, age, stage, and BMI. In addition, fasting adiponectin and chemerin levels were associated with fasting insulin levels after adjustment for gender, age, stage, and BMI. In our combined analyses, participants with high adiponectin and low chemerin levels showed significantly lower fasting insulin levels (4.92 ± 0.75 vs. 8.07 ± 0.80 μU/ml, p < 0.01) compared with participants with low adiponectin and high chemerin levels. Multiple linear regression analysis confirmed that cardiopulmonary fitness and adiponectin levels (β = −0.299, p = 0.002; β = −0.201, p = 0.033) were independently associated with fasting insulin level. Conclusion: Our results suggest that physical fitness and adiponectin and chemerin levels may contribute to circulating levels of insulin. These results suggest that exercise may influence the prognosis of colorectal cancer patients by influencing physical fitness level, circulating levels of adiponectin and chemerin.

AB - Purpose: Since circulating level of insulin is associated with colorectal cancer prognosis, it is important to identify factors contributing to fasting insulin level in colorectal cancer patients. The purpose of the current study is to investigate the association of physical fitness, adiponectin, and chemerin levels with circulating level of insulin in colorectal cancer patients. Methods: A total of 123 stage II-III colorectal cancer patients who completed standard cancer treatment were recruited. Anthropometric characteristics, fitness measurements, fasting insulin level, homeostasis model assessment of insulin resistance, lipid profiles, and adiponectin and chemerin levels were analyzed. Result: Cardiopulmonary fitness level inversely associated with fasting insulin levels (the least fit (1st tertile): 8.11 ± 0.64, moderately fit (2nd tertile): 6.02 ± 0.63, and highly fit (3rd tertile): 5.58 ± 0.66 μU/ml, unfit vs. moderately fit, p < 0.01; unfit vs. highly fit, p < 0.05) after adjustment for gender, age, stage, and BMI. In addition, fasting adiponectin and chemerin levels were associated with fasting insulin levels after adjustment for gender, age, stage, and BMI. In our combined analyses, participants with high adiponectin and low chemerin levels showed significantly lower fasting insulin levels (4.92 ± 0.75 vs. 8.07 ± 0.80 μU/ml, p < 0.01) compared with participants with low adiponectin and high chemerin levels. Multiple linear regression analysis confirmed that cardiopulmonary fitness and adiponectin levels (β = −0.299, p = 0.002; β = −0.201, p = 0.033) were independently associated with fasting insulin level. Conclusion: Our results suggest that physical fitness and adiponectin and chemerin levels may contribute to circulating levels of insulin. These results suggest that exercise may influence the prognosis of colorectal cancer patients by influencing physical fitness level, circulating levels of adiponectin and chemerin.

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