Cardiovascular risk among stable individuals suspected of having coronary artery disease with no modifiable risk factors: Results from an international multicenter study of 5262 patients

Jonathon Leipsic, Carolyn M. Taylor, Gilat Grunau, Brett G. Heilbron, G. B.John Mancini, Stephan Achenbach, Mouaz Al-Mallah, Daniel S. Berman, Matthew J. Budoff, Filippo Cademartiri, Tracy Q. Callister, Hyuk Jae Chang, Victor Y. Cheng, Kavitha Chinnaiyan, Benjamin J.W. Chow, Augustin Delago, Martin Hadamitzky, Joerg Hausleiter Ricardo Cury, Gudrun Feuchtner, Yong Jin KimPhilipp A. Kaufmann, Fay Y. Lin, Erica Maffei, Gilbert Raff, Leslee J. Shaw, Todd C. Villines, James K. Min

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Abstract

Purpose: To assess the prevalence, extent, severity, and risk of coronary artery disease (CAD) in patients suspected of having CAD but with no medically modifiable risk factors. Materials and Methods: Institutional review board approval or waiver of consent was obtained at each center. This study was HIPAA compliant. From an international multicenter cohort study of 27 125 subjects undergoing coronary computed tomographic (CT) angiography from 12 centers, 5262 patients without known CAD and without modifiable risk factors were identified. CAD severity was defined as none (0%), mild (1%-49%), or obstructive (≥50%) on a per-patient, per-vessel, and per-segment basis. CAD presence, extent, and severity were related to incidence of major adverse cardiovascular event (MACE) by using Cox proportional hazards models. Results: At a mean follow-up of 2.3 years ± 1.2 (standard deviation), MACE occurred in 106 patients. CAD was common for nonobstructive (n = 1452, 27%) and obstructive (n = 629, 12%) CAD. In risk-adjusted analysis, per-patient obstructive CAD (hazard ratio [HR], 6.64; 95% confidence interval [CI]: 3.68, 12.00; P ≤ .001) was related to MACE. MACE was associated with a dose-response relationship to the number of vessels exhibiting obstructive CAD, increasing risk for obstructive one-vessel (HR, 6.11; 95% CI: 3.22, 11.6; P ≤ .001), two-vessel (HR, 5.86; 95% CI: 2.75, 12.5; P ≤ .0001), or three-vessel or left main (HR, 11.69; 95% CI: 5.38, 25.4; P ≤ .001) CAD. The increased hazard for MACE of obstructive disease holds true for symptomatic (HR, 11.9; 95% CI: 4.81, 29.6; P ≤ .001) and asymptomatic (HR, 6.3; 95% CI: 2.4, 16.7; P ≤ .001) patients. No CAD at coronary CT angiography was associated with a low annualized MACE rate: 0.31% versus 2.06% with obstructive disease. Conclusion: Among individuals suspected of having CAD but without modifiable risk factors, CAD is common, with significantly increased hazards for MACE and mortality.

Original languageEnglish
Pages (from-to)718-726
Number of pages9
JournalRadiology
Volume267
Issue number3
DOIs
Publication statusPublished - 2013 Jun 1

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Multicenter Studies
Coronary Artery Disease
Confidence Intervals
Angiography
Health Insurance Portability and Accountability Act
Research Ethics Committees
Proportional Hazards Models
Cohort Studies

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Leipsic, Jonathon ; Taylor, Carolyn M. ; Grunau, Gilat ; Heilbron, Brett G. ; Mancini, G. B.John ; Achenbach, Stephan ; Al-Mallah, Mouaz ; Berman, Daniel S. ; Budoff, Matthew J. ; Cademartiri, Filippo ; Callister, Tracy Q. ; Chang, Hyuk Jae ; Cheng, Victor Y. ; Chinnaiyan, Kavitha ; Chow, Benjamin J.W. ; Delago, Augustin ; Hadamitzky, Martin ; Cury, Joerg Hausleiter Ricardo ; Feuchtner, Gudrun ; Kim, Yong Jin ; Kaufmann, Philipp A. ; Lin, Fay Y. ; Maffei, Erica ; Raff, Gilbert ; Shaw, Leslee J. ; Villines, Todd C. ; Min, James K. / Cardiovascular risk among stable individuals suspected of having coronary artery disease with no modifiable risk factors : Results from an international multicenter study of 5262 patients. In: Radiology. 2013 ; Vol. 267, No. 3. pp. 718-726.
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title = "Cardiovascular risk among stable individuals suspected of having coronary artery disease with no modifiable risk factors: Results from an international multicenter study of 5262 patients",
abstract = "Purpose: To assess the prevalence, extent, severity, and risk of coronary artery disease (CAD) in patients suspected of having CAD but with no medically modifiable risk factors. Materials and Methods: Institutional review board approval or waiver of consent was obtained at each center. This study was HIPAA compliant. From an international multicenter cohort study of 27 125 subjects undergoing coronary computed tomographic (CT) angiography from 12 centers, 5262 patients without known CAD and without modifiable risk factors were identified. CAD severity was defined as none (0{\%}), mild (1{\%}-49{\%}), or obstructive (≥50{\%}) on a per-patient, per-vessel, and per-segment basis. CAD presence, extent, and severity were related to incidence of major adverse cardiovascular event (MACE) by using Cox proportional hazards models. Results: At a mean follow-up of 2.3 years ± 1.2 (standard deviation), MACE occurred in 106 patients. CAD was common for nonobstructive (n = 1452, 27{\%}) and obstructive (n = 629, 12{\%}) CAD. In risk-adjusted analysis, per-patient obstructive CAD (hazard ratio [HR], 6.64; 95{\%} confidence interval [CI]: 3.68, 12.00; P ≤ .001) was related to MACE. MACE was associated with a dose-response relationship to the number of vessels exhibiting obstructive CAD, increasing risk for obstructive one-vessel (HR, 6.11; 95{\%} CI: 3.22, 11.6; P ≤ .001), two-vessel (HR, 5.86; 95{\%} CI: 2.75, 12.5; P ≤ .0001), or three-vessel or left main (HR, 11.69; 95{\%} CI: 5.38, 25.4; P ≤ .001) CAD. The increased hazard for MACE of obstructive disease holds true for symptomatic (HR, 11.9; 95{\%} CI: 4.81, 29.6; P ≤ .001) and asymptomatic (HR, 6.3; 95{\%} CI: 2.4, 16.7; P ≤ .001) patients. No CAD at coronary CT angiography was associated with a low annualized MACE rate: 0.31{\%} versus 2.06{\%} with obstructive disease. Conclusion: Among individuals suspected of having CAD but without modifiable risk factors, CAD is common, with significantly increased hazards for MACE and mortality.",
author = "Jonathon Leipsic and Taylor, {Carolyn M.} and Gilat Grunau and Heilbron, {Brett G.} and Mancini, {G. B.John} and Stephan Achenbach and Mouaz Al-Mallah and Berman, {Daniel S.} and Budoff, {Matthew J.} and Filippo Cademartiri and Callister, {Tracy Q.} and Chang, {Hyuk Jae} and Cheng, {Victor Y.} and Kavitha Chinnaiyan and Chow, {Benjamin J.W.} and Augustin Delago and Martin Hadamitzky and Cury, {Joerg Hausleiter Ricardo} and Gudrun Feuchtner and Kim, {Yong Jin} and Kaufmann, {Philipp A.} and Lin, {Fay Y.} and Erica Maffei and Gilbert Raff and Shaw, {Leslee J.} and Villines, {Todd C.} and Min, {James K.}",
year = "2013",
month = "6",
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doi = "10.1148/radiol.13121669",
language = "English",
volume = "267",
pages = "718--726",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "3",

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Leipsic, J, Taylor, CM, Grunau, G, Heilbron, BG, Mancini, GBJ, Achenbach, S, Al-Mallah, M, Berman, DS, Budoff, MJ, Cademartiri, F, Callister, TQ, Chang, HJ, Cheng, VY, Chinnaiyan, K, Chow, BJW, Delago, A, Hadamitzky, M, Cury, JHR, Feuchtner, G, Kim, YJ, Kaufmann, PA, Lin, FY, Maffei, E, Raff, G, Shaw, LJ, Villines, TC & Min, JK 2013, 'Cardiovascular risk among stable individuals suspected of having coronary artery disease with no modifiable risk factors: Results from an international multicenter study of 5262 patients', Radiology, vol. 267, no. 3, pp. 718-726. https://doi.org/10.1148/radiol.13121669

Cardiovascular risk among stable individuals suspected of having coronary artery disease with no modifiable risk factors : Results from an international multicenter study of 5262 patients. / Leipsic, Jonathon; Taylor, Carolyn M.; Grunau, Gilat; Heilbron, Brett G.; Mancini, G. B.John; Achenbach, Stephan; Al-Mallah, Mouaz; Berman, Daniel S.; Budoff, Matthew J.; Cademartiri, Filippo; Callister, Tracy Q.; Chang, Hyuk Jae; Cheng, Victor Y.; Chinnaiyan, Kavitha; Chow, Benjamin J.W.; Delago, Augustin; Hadamitzky, Martin; Cury, Joerg Hausleiter Ricardo; Feuchtner, Gudrun; Kim, Yong Jin; Kaufmann, Philipp A.; Lin, Fay Y.; Maffei, Erica; Raff, Gilbert; Shaw, Leslee J.; Villines, Todd C.; Min, James K.

In: Radiology, Vol. 267, No. 3, 01.06.2013, p. 718-726.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cardiovascular risk among stable individuals suspected of having coronary artery disease with no modifiable risk factors

T2 - Results from an international multicenter study of 5262 patients

AU - Leipsic, Jonathon

AU - Taylor, Carolyn M.

AU - Grunau, Gilat

AU - Heilbron, Brett G.

AU - Mancini, G. B.John

AU - Achenbach, Stephan

AU - Al-Mallah, Mouaz

AU - Berman, Daniel S.

AU - Budoff, Matthew J.

AU - Cademartiri, Filippo

AU - Callister, Tracy Q.

AU - Chang, Hyuk Jae

AU - Cheng, Victor Y.

AU - Chinnaiyan, Kavitha

AU - Chow, Benjamin J.W.

AU - Delago, Augustin

AU - Hadamitzky, Martin

AU - Cury, Joerg Hausleiter Ricardo

AU - Feuchtner, Gudrun

AU - Kim, Yong Jin

AU - Kaufmann, Philipp A.

AU - Lin, Fay Y.

AU - Maffei, Erica

AU - Raff, Gilbert

AU - Shaw, Leslee J.

AU - Villines, Todd C.

AU - Min, James K.

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Purpose: To assess the prevalence, extent, severity, and risk of coronary artery disease (CAD) in patients suspected of having CAD but with no medically modifiable risk factors. Materials and Methods: Institutional review board approval or waiver of consent was obtained at each center. This study was HIPAA compliant. From an international multicenter cohort study of 27 125 subjects undergoing coronary computed tomographic (CT) angiography from 12 centers, 5262 patients without known CAD and without modifiable risk factors were identified. CAD severity was defined as none (0%), mild (1%-49%), or obstructive (≥50%) on a per-patient, per-vessel, and per-segment basis. CAD presence, extent, and severity were related to incidence of major adverse cardiovascular event (MACE) by using Cox proportional hazards models. Results: At a mean follow-up of 2.3 years ± 1.2 (standard deviation), MACE occurred in 106 patients. CAD was common for nonobstructive (n = 1452, 27%) and obstructive (n = 629, 12%) CAD. In risk-adjusted analysis, per-patient obstructive CAD (hazard ratio [HR], 6.64; 95% confidence interval [CI]: 3.68, 12.00; P ≤ .001) was related to MACE. MACE was associated with a dose-response relationship to the number of vessels exhibiting obstructive CAD, increasing risk for obstructive one-vessel (HR, 6.11; 95% CI: 3.22, 11.6; P ≤ .001), two-vessel (HR, 5.86; 95% CI: 2.75, 12.5; P ≤ .0001), or three-vessel or left main (HR, 11.69; 95% CI: 5.38, 25.4; P ≤ .001) CAD. The increased hazard for MACE of obstructive disease holds true for symptomatic (HR, 11.9; 95% CI: 4.81, 29.6; P ≤ .001) and asymptomatic (HR, 6.3; 95% CI: 2.4, 16.7; P ≤ .001) patients. No CAD at coronary CT angiography was associated with a low annualized MACE rate: 0.31% versus 2.06% with obstructive disease. Conclusion: Among individuals suspected of having CAD but without modifiable risk factors, CAD is common, with significantly increased hazards for MACE and mortality.

AB - Purpose: To assess the prevalence, extent, severity, and risk of coronary artery disease (CAD) in patients suspected of having CAD but with no medically modifiable risk factors. Materials and Methods: Institutional review board approval or waiver of consent was obtained at each center. This study was HIPAA compliant. From an international multicenter cohort study of 27 125 subjects undergoing coronary computed tomographic (CT) angiography from 12 centers, 5262 patients without known CAD and without modifiable risk factors were identified. CAD severity was defined as none (0%), mild (1%-49%), or obstructive (≥50%) on a per-patient, per-vessel, and per-segment basis. CAD presence, extent, and severity were related to incidence of major adverse cardiovascular event (MACE) by using Cox proportional hazards models. Results: At a mean follow-up of 2.3 years ± 1.2 (standard deviation), MACE occurred in 106 patients. CAD was common for nonobstructive (n = 1452, 27%) and obstructive (n = 629, 12%) CAD. In risk-adjusted analysis, per-patient obstructive CAD (hazard ratio [HR], 6.64; 95% confidence interval [CI]: 3.68, 12.00; P ≤ .001) was related to MACE. MACE was associated with a dose-response relationship to the number of vessels exhibiting obstructive CAD, increasing risk for obstructive one-vessel (HR, 6.11; 95% CI: 3.22, 11.6; P ≤ .001), two-vessel (HR, 5.86; 95% CI: 2.75, 12.5; P ≤ .0001), or three-vessel or left main (HR, 11.69; 95% CI: 5.38, 25.4; P ≤ .001) CAD. The increased hazard for MACE of obstructive disease holds true for symptomatic (HR, 11.9; 95% CI: 4.81, 29.6; P ≤ .001) and asymptomatic (HR, 6.3; 95% CI: 2.4, 16.7; P ≤ .001) patients. No CAD at coronary CT angiography was associated with a low annualized MACE rate: 0.31% versus 2.06% with obstructive disease. Conclusion: Among individuals suspected of having CAD but without modifiable risk factors, CAD is common, with significantly increased hazards for MACE and mortality.

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