Catabolic metabolism during cancer EMT

Yong Hoon Cha, Jong In Yook, Hyun Sil Kim, Nam Hee Kim

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)

Abstract

Aerobic glycolysis is widely accepted as the glucose metabolism for production of biomass such as nucleotides, amino acids, and fatty acids which underlie the anabolic process of cancer cell proliferation. The epithelial-mesenchymal transition (EMT) is a complex cellular mechanism for invasion and metastatic progression in cancer cells. While Snail-mediated EMT regulated by major oncogenic signaling has been well-studied over the last decade, metabolic reprogramming during the EMT has not. In this work, we emphasize the importance of catabolic metabolism for cancer cell survival during cancer cell EMT. Because specific catabolic processes such as autophage and fatty acid oxidation have been well explained, we mainly focus on the general aspects of energy metabolism promoting cancer cell survival under metabolic stress. We also revisit the role of mitochondria in catabolism as oxidative phosphorylation in cancer has long been underestimated. Considering the highly inefficient process of metastatic progression and profound metabolic stress following matrix detachment of solid cancer, catabolic reprogramming during the EMT may play an important role in overcoming metastatic inefficiency of cancer cells.

Original languageEnglish
Pages (from-to)313-320
Number of pages8
JournalArchives of pharmacal research
Volume38
Issue number3
DOIs
Publication statusPublished - 2015 Mar

Bibliographical note

Publisher Copyright:
© 2015 The Pharmaceutical Society of Korea.

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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