Catheter ablation of atrial fibrillation raises the plasma level of NGF-β which is associated with sympathetic nerve activity

Jae Hyung Park, Sung Yu Hong, Jin Wi, Da Lyung Lee, Boyoung Joung, Moon Hyoung Lee, Hui Nam Pak

Research output: Contribution to journalArticle

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Abstract

Purpose: The expression of nerve growth factor-β (NGF-β) is related to cardiac nerve sprouting and sympathetic hyper innervation. We investigated the changes of plasma levels of NGF-β and the relationship to follow-up heart rate variability (HRV) after radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF). Materials and Methods: This study included 147 patients with AF (117 men, 55.8±11.5 years, 106 paroxysmal AF) who underwent RFCA. The plasma levels of NGF-β were quantified using double sandwich enzyme linked immunosorbent assay method before (NGF-βpre) and 1 hour after RFCA (NGF-βpost-1hr). HRV at pre-procedure (HRVpre), 3 months (HRVpost-3mo), and 1 year post-procedure (HRVpost-1yr) were analyzed and compared with plasma levels of NGF-β. Results: 1) The plasma levels of NGF-β significantly increased after RFCA (20.05±11.09 pg/mL vs. 29.60±19.43 pg/mL, p<0.001). The patients who did not show increased NGF-βpost-1hr were older (p=0.023) and had greater left atrial volume index (p=0.028) than those with increased NGF-βpost-1hr. 2) In patients with NGF-βpre >18 pg/mL, low frequency components (LF)/high-frequency components (HF) (p=0.003) and the number of atrial premature contractions (APCs, p=0.045) in HRVpost-3mo were significantly higher than those with ≤18 pg/mL. 3) The LF/HF at HRVpost-3mo was linearly associated with the NGF-βpre (B=4.240, 95% CI 1.114–7.336, p=0.008) and the NGF-βpost-1hr (B=7.617, 95% CI 2.106–13.127, p=0.007). 4) Both NGF-βpre (OR=1.159, 95% CI 1.045–1.286, p=0.005) and NGF-βpost-1hr (OR=1.098, 95% CI 1.030–1.170, p=0.004) were independent predictors for the increase of LF/HF at HRVpost-3mo. Conclusion: AF catheter ablation increases plasma level of NGF-β, and high plasma levels of NGF-βpre was associated with higher sympathetic nerve activity and higher frequency of APCs in HRVpost-3mo.

Original languageEnglish
Pages (from-to)1530-1537
Number of pages8
JournalYonsei medical journal
Volume56
Issue number6
DOIs
Publication statusPublished - 2015 Nov

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Catheter Ablation
Nerve Growth Factor
Atrial Fibrillation
Heart Rate
Atrial Premature Complexes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Park, Jae Hyung ; Hong, Sung Yu ; Wi, Jin ; Lee, Da Lyung ; Joung, Boyoung ; Lee, Moon Hyoung ; Pak, Hui Nam. / Catheter ablation of atrial fibrillation raises the plasma level of NGF-β which is associated with sympathetic nerve activity. In: Yonsei medical journal. 2015 ; Vol. 56, No. 6. pp. 1530-1537.
@article{3e50d2bc85874fd0987c7eca0c2b7e10,
title = "Catheter ablation of atrial fibrillation raises the plasma level of NGF-β which is associated with sympathetic nerve activity",
abstract = "Purpose: The expression of nerve growth factor-β (NGF-β) is related to cardiac nerve sprouting and sympathetic hyper innervation. We investigated the changes of plasma levels of NGF-β and the relationship to follow-up heart rate variability (HRV) after radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF). Materials and Methods: This study included 147 patients with AF (117 men, 55.8±11.5 years, 106 paroxysmal AF) who underwent RFCA. The plasma levels of NGF-β were quantified using double sandwich enzyme linked immunosorbent assay method before (NGF-βpre) and 1 hour after RFCA (NGF-βpost-1hr). HRV at pre-procedure (HRVpre), 3 months (HRVpost-3mo), and 1 year post-procedure (HRVpost-1yr) were analyzed and compared with plasma levels of NGF-β. Results: 1) The plasma levels of NGF-β significantly increased after RFCA (20.05±11.09 pg/mL vs. 29.60±19.43 pg/mL, p<0.001). The patients who did not show increased NGF-βpost-1hr were older (p=0.023) and had greater left atrial volume index (p=0.028) than those with increased NGF-βpost-1hr. 2) In patients with NGF-βpre >18 pg/mL, low frequency components (LF)/high-frequency components (HF) (p=0.003) and the number of atrial premature contractions (APCs, p=0.045) in HRVpost-3mo were significantly higher than those with ≤18 pg/mL. 3) The LF/HF at HRVpost-3mo was linearly associated with the NGF-βpre (B=4.240, 95{\%} CI 1.114–7.336, p=0.008) and the NGF-βpost-1hr (B=7.617, 95{\%} CI 2.106–13.127, p=0.007). 4) Both NGF-βpre (OR=1.159, 95{\%} CI 1.045–1.286, p=0.005) and NGF-βpost-1hr (OR=1.098, 95{\%} CI 1.030–1.170, p=0.004) were independent predictors for the increase of LF/HF at HRVpost-3mo. Conclusion: AF catheter ablation increases plasma level of NGF-β, and high plasma levels of NGF-βpre was associated with higher sympathetic nerve activity and higher frequency of APCs in HRVpost-3mo.",
author = "Park, {Jae Hyung} and Hong, {Sung Yu} and Jin Wi and Lee, {Da Lyung} and Boyoung Joung and Lee, {Moon Hyoung} and Pak, {Hui Nam}",
year = "2015",
month = "11",
doi = "10.3349/ymj.2015.56.6.1530",
language = "English",
volume = "56",
pages = "1530--1537",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
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}

Catheter ablation of atrial fibrillation raises the plasma level of NGF-β which is associated with sympathetic nerve activity. / Park, Jae Hyung; Hong, Sung Yu; Wi, Jin; Lee, Da Lyung; Joung, Boyoung; Lee, Moon Hyoung; Pak, Hui Nam.

In: Yonsei medical journal, Vol. 56, No. 6, 11.2015, p. 1530-1537.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Catheter ablation of atrial fibrillation raises the plasma level of NGF-β which is associated with sympathetic nerve activity

AU - Park, Jae Hyung

AU - Hong, Sung Yu

AU - Wi, Jin

AU - Lee, Da Lyung

AU - Joung, Boyoung

AU - Lee, Moon Hyoung

AU - Pak, Hui Nam

PY - 2015/11

Y1 - 2015/11

N2 - Purpose: The expression of nerve growth factor-β (NGF-β) is related to cardiac nerve sprouting and sympathetic hyper innervation. We investigated the changes of plasma levels of NGF-β and the relationship to follow-up heart rate variability (HRV) after radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF). Materials and Methods: This study included 147 patients with AF (117 men, 55.8±11.5 years, 106 paroxysmal AF) who underwent RFCA. The plasma levels of NGF-β were quantified using double sandwich enzyme linked immunosorbent assay method before (NGF-βpre) and 1 hour after RFCA (NGF-βpost-1hr). HRV at pre-procedure (HRVpre), 3 months (HRVpost-3mo), and 1 year post-procedure (HRVpost-1yr) were analyzed and compared with plasma levels of NGF-β. Results: 1) The plasma levels of NGF-β significantly increased after RFCA (20.05±11.09 pg/mL vs. 29.60±19.43 pg/mL, p<0.001). The patients who did not show increased NGF-βpost-1hr were older (p=0.023) and had greater left atrial volume index (p=0.028) than those with increased NGF-βpost-1hr. 2) In patients with NGF-βpre >18 pg/mL, low frequency components (LF)/high-frequency components (HF) (p=0.003) and the number of atrial premature contractions (APCs, p=0.045) in HRVpost-3mo were significantly higher than those with ≤18 pg/mL. 3) The LF/HF at HRVpost-3mo was linearly associated with the NGF-βpre (B=4.240, 95% CI 1.114–7.336, p=0.008) and the NGF-βpost-1hr (B=7.617, 95% CI 2.106–13.127, p=0.007). 4) Both NGF-βpre (OR=1.159, 95% CI 1.045–1.286, p=0.005) and NGF-βpost-1hr (OR=1.098, 95% CI 1.030–1.170, p=0.004) were independent predictors for the increase of LF/HF at HRVpost-3mo. Conclusion: AF catheter ablation increases plasma level of NGF-β, and high plasma levels of NGF-βpre was associated with higher sympathetic nerve activity and higher frequency of APCs in HRVpost-3mo.

AB - Purpose: The expression of nerve growth factor-β (NGF-β) is related to cardiac nerve sprouting and sympathetic hyper innervation. We investigated the changes of plasma levels of NGF-β and the relationship to follow-up heart rate variability (HRV) after radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF). Materials and Methods: This study included 147 patients with AF (117 men, 55.8±11.5 years, 106 paroxysmal AF) who underwent RFCA. The plasma levels of NGF-β were quantified using double sandwich enzyme linked immunosorbent assay method before (NGF-βpre) and 1 hour after RFCA (NGF-βpost-1hr). HRV at pre-procedure (HRVpre), 3 months (HRVpost-3mo), and 1 year post-procedure (HRVpost-1yr) were analyzed and compared with plasma levels of NGF-β. Results: 1) The plasma levels of NGF-β significantly increased after RFCA (20.05±11.09 pg/mL vs. 29.60±19.43 pg/mL, p<0.001). The patients who did not show increased NGF-βpost-1hr were older (p=0.023) and had greater left atrial volume index (p=0.028) than those with increased NGF-βpost-1hr. 2) In patients with NGF-βpre >18 pg/mL, low frequency components (LF)/high-frequency components (HF) (p=0.003) and the number of atrial premature contractions (APCs, p=0.045) in HRVpost-3mo were significantly higher than those with ≤18 pg/mL. 3) The LF/HF at HRVpost-3mo was linearly associated with the NGF-βpre (B=4.240, 95% CI 1.114–7.336, p=0.008) and the NGF-βpost-1hr (B=7.617, 95% CI 2.106–13.127, p=0.007). 4) Both NGF-βpre (OR=1.159, 95% CI 1.045–1.286, p=0.005) and NGF-βpost-1hr (OR=1.098, 95% CI 1.030–1.170, p=0.004) were independent predictors for the increase of LF/HF at HRVpost-3mo. Conclusion: AF catheter ablation increases plasma level of NGF-β, and high plasma levels of NGF-βpre was associated with higher sympathetic nerve activity and higher frequency of APCs in HRVpost-3mo.

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