Cationic Poly(Amino Acid) Vaccine Adjuvant for Promoting Both Cell-Mediated and Humoral Immunity Against Influenza Virus

Jong Woo Lim, Woonsung Na, Hyun Ouk Kim, Minjoo Yeom, Geunseon Park, Aram Kang, Haejin Chun, Chaewon Park, Seungseok Oh, Van Phan Le, Hyoung Hwa Jeong, Daesub Song, Seungjoo Haam

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2 Citations (Scopus)

Abstract

Powerful adjuvants to augment vaccine efficacy with a less immunogenic vaccine system are in great demand. In this study, a novel squalene-based cationic poly(amino acid) adjuvant (CASq) that elicits both cellular (Th1) and humoral (Th2) immune responses is developed. CASq is demonstrated to promote cellular uptake of viral antigen and stimulate macrophages, leading to active production of interleukin-12. Furthermore, co-administration of inactivated pdm H1N1 vaccine with CASq significantly increases the generation of antigen-specific antibodies and T cell immune responses in mice, as well as resulting in complete prevention of disease symptoms and protection against lethal infection.

Original languageEnglish
Article number1800953
JournalAdvanced Healthcare Materials
Volume8
Issue number2
DOIs
Publication statusPublished - 2019 Jan 24

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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    Lim, J. W., Na, W., Kim, H. O., Yeom, M., Park, G., Kang, A., Chun, H., Park, C., Oh, S., Le, V. P., Jeong, H. H., Song, D., & Haam, S. (2019). Cationic Poly(Amino Acid) Vaccine Adjuvant for Promoting Both Cell-Mediated and Humoral Immunity Against Influenza Virus. Advanced Healthcare Materials, 8(2), [1800953]. https://doi.org/10.1002/adhm.201800953