Cationic Poly(Amino Acid) Vaccine Adjuvant for Promoting Both Cell-Mediated and Humoral Immunity Against Influenza Virus

Jong Woo Lim, Woonsung Na, Hyun Ouk Kim, Minjoo Yeom, Geunseon Park, Aram Kang, Haejin Chun, Chaewon Park, Seungseok Oh, Van Phan Le, Hyoung Hwa Jeong, Daesub Song, Seungjoo Haam

Research output: Contribution to journalArticle

Abstract

Powerful adjuvants to augment vaccine efficacy with a less immunogenic vaccine system are in great demand. In this study, a novel squalene-based cationic poly(amino acid) adjuvant (CASq) that elicits both cellular (Th1) and humoral (Th2) immune responses is developed. CASq is demonstrated to promote cellular uptake of viral antigen and stimulate macrophages, leading to active production of interleukin-12. Furthermore, co-administration of inactivated pdm H1N1 vaccine with CASq significantly increases the generation of antigen-specific antibodies and T cell immune responses in mice, as well as resulting in complete prevention of disease symptoms and protection against lethal infection.

Original languageEnglish
Article number1800953
JournalAdvanced Healthcare Materials
Volume8
Issue number2
DOIs
Publication statusPublished - 2019 Jan 24

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Vaccines
Humoral Immunity
Orthomyxoviridae
Viruses
Cellular Immunity
Amino acids
Antigens
Amino Acids
Squalene
T-cells
Viral Antigens
Macrophages
Interleukin-12
Antibodies
T-Lymphocytes
Infection

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

Lim, Jong Woo ; Na, Woonsung ; Kim, Hyun Ouk ; Yeom, Minjoo ; Park, Geunseon ; Kang, Aram ; Chun, Haejin ; Park, Chaewon ; Oh, Seungseok ; Le, Van Phan ; Jeong, Hyoung Hwa ; Song, Daesub ; Haam, Seungjoo. / Cationic Poly(Amino Acid) Vaccine Adjuvant for Promoting Both Cell-Mediated and Humoral Immunity Against Influenza Virus. In: Advanced Healthcare Materials. 2019 ; Vol. 8, No. 2.
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Lim, JW, Na, W, Kim, HO, Yeom, M, Park, G, Kang, A, Chun, H, Park, C, Oh, S, Le, VP, Jeong, HH, Song, D & Haam, S 2019, 'Cationic Poly(Amino Acid) Vaccine Adjuvant for Promoting Both Cell-Mediated and Humoral Immunity Against Influenza Virus', Advanced Healthcare Materials, vol. 8, no. 2, 1800953. https://doi.org/10.1002/adhm.201800953

Cationic Poly(Amino Acid) Vaccine Adjuvant for Promoting Both Cell-Mediated and Humoral Immunity Against Influenza Virus. / Lim, Jong Woo; Na, Woonsung; Kim, Hyun Ouk; Yeom, Minjoo; Park, Geunseon; Kang, Aram; Chun, Haejin; Park, Chaewon; Oh, Seungseok; Le, Van Phan; Jeong, Hyoung Hwa; Song, Daesub; Haam, Seungjoo.

In: Advanced Healthcare Materials, Vol. 8, No. 2, 1800953, 24.01.2019.

Research output: Contribution to journalArticle

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AU - Lim, Jong Woo

AU - Na, Woonsung

AU - Kim, Hyun Ouk

AU - Yeom, Minjoo

AU - Park, Geunseon

AU - Kang, Aram

AU - Chun, Haejin

AU - Park, Chaewon

AU - Oh, Seungseok

AU - Le, Van Phan

AU - Jeong, Hyoung Hwa

AU - Song, Daesub

AU - Haam, Seungjoo

PY - 2019/1/24

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