Abstract
Powerful adjuvants to augment vaccine efficacy with a less immunogenic vaccine system are in great demand. In this study, a novel squalene-based cationic poly(amino acid) adjuvant (CASq) that elicits both cellular (Th1) and humoral (Th2) immune responses is developed. CASq is demonstrated to promote cellular uptake of viral antigen and stimulate macrophages, leading to active production of interleukin-12. Furthermore, co-administration of inactivated pdm H1N1 vaccine with CASq significantly increases the generation of antigen-specific antibodies and T cell immune responses in mice, as well as resulting in complete prevention of disease symptoms and protection against lethal infection.
| Original language | English |
|---|---|
| Article number | 1800953 |
| Journal | Advanced Healthcare Materials |
| Volume | 8 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2019 Jan 24 |
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All Science Journal Classification (ASJC) codes
- Biomaterials
- Biomedical Engineering
- Pharmaceutical Science
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}
Cationic Poly(Amino Acid) Vaccine Adjuvant for Promoting Both Cell-Mediated and Humoral Immunity Against Influenza Virus. / Lim, Jong Woo; Na, Woonsung; Kim, Hyun Ouk; Yeom, Minjoo; Park, Geunseon; Kang, Aram; Chun, Haejin; Park, Chaewon; Oh, Seungseok; Le, Van Phan; Jeong, Hyoung Hwa; Song, Daesub; Haam, Seungjoo.
In: Advanced Healthcare Materials, Vol. 8, No. 2, 1800953, 24.01.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - Cationic Poly(Amino Acid) Vaccine Adjuvant for Promoting Both Cell-Mediated and Humoral Immunity Against Influenza Virus
AU - Lim, Jong Woo
AU - Na, Woonsung
AU - Kim, Hyun Ouk
AU - Yeom, Minjoo
AU - Park, Geunseon
AU - Kang, Aram
AU - Chun, Haejin
AU - Park, Chaewon
AU - Oh, Seungseok
AU - Le, Van Phan
AU - Jeong, Hyoung Hwa
AU - Song, Daesub
AU - Haam, Seungjoo
PY - 2019/1/24
Y1 - 2019/1/24
N2 - Powerful adjuvants to augment vaccine efficacy with a less immunogenic vaccine system are in great demand. In this study, a novel squalene-based cationic poly(amino acid) adjuvant (CASq) that elicits both cellular (Th1) and humoral (Th2) immune responses is developed. CASq is demonstrated to promote cellular uptake of viral antigen and stimulate macrophages, leading to active production of interleukin-12. Furthermore, co-administration of inactivated pdm H1N1 vaccine with CASq significantly increases the generation of antigen-specific antibodies and T cell immune responses in mice, as well as resulting in complete prevention of disease symptoms and protection against lethal infection.
AB - Powerful adjuvants to augment vaccine efficacy with a less immunogenic vaccine system are in great demand. In this study, a novel squalene-based cationic poly(amino acid) adjuvant (CASq) that elicits both cellular (Th1) and humoral (Th2) immune responses is developed. CASq is demonstrated to promote cellular uptake of viral antigen and stimulate macrophages, leading to active production of interleukin-12. Furthermore, co-administration of inactivated pdm H1N1 vaccine with CASq significantly increases the generation of antigen-specific antibodies and T cell immune responses in mice, as well as resulting in complete prevention of disease symptoms and protection against lethal infection.
UR - http://www.scopus.com/inward/record.url?scp=85058442959&partnerID=8YFLogxK
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U2 - 10.1002/adhm.201800953
DO - 10.1002/adhm.201800953
M3 - Article
VL - 8
JO - Advanced healthcare materials
JF - Advanced healthcare materials
SN - 2192-2640
IS - 2
M1 - 1800953
ER -