CD30 (Ki-1)-positive large-cell cutaneous T-cell lymphoma with secondary xanthomatous changes after radiation therapy

Han Gil Chung, Yae Lee Chung, Jin Moon Kang, Woo Ick Yang, Chang Ok Suh, Jee Sook Hahn, Min Geol Leea

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A 72-year-old woman with a large mass on her forehead was found to have primary cutaneous CD30-positive large T-cell lymphoma and was treated with radiation therapy. Five weeks after the completion of radiation therapy, a large, yellow plaque developed on the forehead. Histopathologic examination showed numerous xanthoma-like cells with clear and foamy cytoplasm that infiltrated the upper and mid dermis with no residual lymphoma. To our knowledge, this is the first report of xanthomatous change after radiation therapy for primary cutaneous CD30-positive large cell lymphoma. We believe that the xanthomatous change after radiation therapy probably was caused by lysis of radiosensitive lymphoma cells and histiocytic scavenging of lipid-membrane debris.

Original languageEnglish
Pages (from-to)S28-S30
JournalJournal of the American Academy of Dermatology
Issue number2
Publication statusPublished - 2003 Feb 1


All Science Journal Classification (ASJC) codes

  • Dermatology

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