CD30 (Ki-1)-positive large-cell cutaneous T-cell lymphoma with secondary xanthomatous changes after radiation therapy

Han Gil Chung, Yae Lee Chung, Jin Moon Kang, Woo Ick Yang, Chang Ok Suh, Jee Sook Hahn, Min Geol Leea

Research output: Contribution to journalArticle

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Abstract

A 72-year-old woman with a large mass on her forehead was found to have primary cutaneous CD30-positive large T-cell lymphoma and was treated with radiation therapy. Five weeks after the completion of radiation therapy, a large, yellow plaque developed on the forehead. Histopathologic examination showed numerous xanthoma-like cells with clear and foamy cytoplasm that infiltrated the upper and mid dermis with no residual lymphoma. To our knowledge, this is the first report of xanthomatous change after radiation therapy for primary cutaneous CD30-positive large cell lymphoma. We believe that the xanthomatous change after radiation therapy probably was caused by lysis of radiosensitive lymphoma cells and histiocytic scavenging of lipid-membrane debris.

Original languageEnglish
JournalJournal of the American Academy of Dermatology
Volume48
Issue number2
DOIs
Publication statusPublished - 2003 Feb 1

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Cutaneous T-Cell Lymphoma
Radiotherapy
Forehead
Primary Cutaneous Anaplastic Large Cell Lymphoma
Lymphoma
Xanthomatosis
Lymphoma, Large B-Cell, Diffuse
Dermis
Membrane Lipids
Cytoplasm
Skin

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Chung, Han Gil ; Chung, Yae Lee ; Kang, Jin Moon ; Yang, Woo Ick ; Suh, Chang Ok ; Hahn, Jee Sook ; Leea, Min Geol. / CD30 (Ki-1)-positive large-cell cutaneous T-cell lymphoma with secondary xanthomatous changes after radiation therapy. In: Journal of the American Academy of Dermatology. 2003 ; Vol. 48, No. 2.
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abstract = "A 72-year-old woman with a large mass on her forehead was found to have primary cutaneous CD30-positive large T-cell lymphoma and was treated with radiation therapy. Five weeks after the completion of radiation therapy, a large, yellow plaque developed on the forehead. Histopathologic examination showed numerous xanthoma-like cells with clear and foamy cytoplasm that infiltrated the upper and mid dermis with no residual lymphoma. To our knowledge, this is the first report of xanthomatous change after radiation therapy for primary cutaneous CD30-positive large cell lymphoma. We believe that the xanthomatous change after radiation therapy probably was caused by lysis of radiosensitive lymphoma cells and histiocytic scavenging of lipid-membrane debris.",
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CD30 (Ki-1)-positive large-cell cutaneous T-cell lymphoma with secondary xanthomatous changes after radiation therapy. / Chung, Han Gil; Chung, Yae Lee; Kang, Jin Moon; Yang, Woo Ick; Suh, Chang Ok; Hahn, Jee Sook; Leea, Min Geol.

In: Journal of the American Academy of Dermatology, Vol. 48, No. 2, 01.02.2003.

Research output: Contribution to journalArticle

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AU - Chung, Han Gil

AU - Chung, Yae Lee

AU - Kang, Jin Moon

AU - Yang, Woo Ick

AU - Suh, Chang Ok

AU - Hahn, Jee Sook

AU - Leea, Min Geol

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