CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells

Jungmin Park; Minhee Ku; Eunjung Kim; Yeonji Park; Yoochan Hong; Seungjoo Haam; Jae Ho Cheong; Eun Sung Park; Jin Suck Suh; Yong Min Huh; Jaemoon Yang

doi:10.1039/c3ib20203h

CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells

Jungmin Park, Minhee Ku, Eunjung Kim, Yeonji Park, Yoochan Hong, Seungjoo Haam, Jae Ho Cheong, Eun Sung Park, Jin Suck Suh, Yong Min Huh, Jaemoon Yang

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16 Citations (Scopus)

Abstract

We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.

Original language	English
Pages (from-to)	669-672
Number of pages	4
Journal	Integrative Biology (United Kingdom)
Volume	5
Issue number	4
DOIs	https://doi.org/10.1039/c3ib20203h
Publication status	Published - 2013 Apr

All Science Journal Classification (ASJC) codes

Medicine(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c3ib20203h

Cite this

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title = "CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells",

abstract = "We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.",

author = "Jungmin Park and Minhee Ku and Eunjung Kim and Yeonji Park and Yoochan Hong and Seungjoo Haam and Cheong, {Jae Ho} and Park, {Eun Sung} and Suh, {Jin Suck} and Huh, {Yong Min} and Jaemoon Yang",

year = "2013",

month = apr,

doi = "10.1039/c3ib20203h",

language = "English",

volume = "5",

pages = "669--672",

journal = "Integrative Biology (United Kingdom)",

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publisher = "Royal Society of Chemistry",

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T1 - CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells

AU - Park, Jungmin

AU - Ku, Minhee

AU - Kim, Eunjung

AU - Park, Yeonji

AU - Hong, Yoochan

AU - Haam, Seungjoo

AU - Cheong, Jae Ho

AU - Park, Eun Sung

AU - Suh, Jin Suck

AU - Huh, Yong Min

AU - Yang, Jaemoon

PY - 2013/4

Y1 - 2013/4

N2 - We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.

AB - We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.

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ER -

CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells

Abstract

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UN SDGs

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