CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells

Jungmin Park, Minhee Ku, Eunjung Kim, Yeonji Park, Yoochan Hong, Seungjoo Haam, Jae Ho Cheong, Eun Sung Park, Jin Suck Suh, Yong Min Huh, Jaemoon Yang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.

Original languageEnglish
Pages (from-to)669-672
Number of pages4
JournalIntegrative Biology (United Kingdom)
Volume5
Issue number4
DOIs
Publication statusPublished - 2013 Apr 1

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Molecular imaging
Hydrogels
Molecular Imaging
Optical Imaging
Stomach Neoplasms
Fluorescence
Cells
Infrared radiation
Polyethyleneimine
Molecular Probes
Hydrogel
Hyaluronic Acid
Biocompatibility
Heterografts
Imaging techniques
Water
CY5.5 cyanine dye

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry

Cite this

Park, Jungmin ; Ku, Minhee ; Kim, Eunjung ; Park, Yeonji ; Hong, Yoochan ; Haam, Seungjoo ; Cheong, Jae Ho ; Park, Eun Sung ; Suh, Jin Suck ; Huh, Yong Min ; Yang, Jaemoon. / CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells. In: Integrative Biology (United Kingdom). 2013 ; Vol. 5, No. 4. pp. 669-672.
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CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells. / Park, Jungmin; Ku, Minhee; Kim, Eunjung; Park, Yeonji; Hong, Yoochan; Haam, Seungjoo; Cheong, Jae Ho; Park, Eun Sung; Suh, Jin Suck; Huh, Yong Min; Yang, Jaemoon.

In: Integrative Biology (United Kingdom), Vol. 5, No. 4, 01.04.2013, p. 669-672.

Research output: Contribution to journalArticle

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AU - Haam, Seungjoo

AU - Cheong, Jae Ho

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