CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells

Jungmin Park, Minhee Ku, Eunjung Kim, Yeonji Park, Yoochan Hong, Seungjoo Haam, Jae Ho Cheong, Eun Sung Park, Jin Suck Suh, Yong Min Huh, Jaemoon Yang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.

Original languageEnglish
Pages (from-to)669-672
Number of pages4
JournalIntegrative Biology (United Kingdom)
Volume5
Issue number4
DOIs
Publication statusPublished - 2013 Apr 1

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry

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