CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations

Yoonmi Seok, Juwon Kim, Jong Rak Choi, Yu Ri Kim, Seo Jin Park, Sue Jung Kim, Jaewoo Song, Kyung A. Lee

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalAnnals of laboratory medicine
Volume32
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Bearings (structural)
Mantle-Cell Lymphoma
Chemotherapy
Aberrations
Refractory materials
Korea
Cytogenetics
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Seok, Yoonmi ; Kim, Juwon ; Choi, Jong Rak ; Kim, Yu Ri ; Park, Seo Jin ; Kim, Sue Jung ; Song, Jaewoo ; Lee, Kyung A. / CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations. In: Annals of laboratory medicine. 2012 ; Vol. 32, No. 1. pp. 95-98.
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CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations. / Seok, Yoonmi; Kim, Juwon; Choi, Jong Rak; Kim, Yu Ri; Park, Seo Jin; Kim, Sue Jung; Song, Jaewoo; Lee, Kyung A.

In: Annals of laboratory medicine, Vol. 32, No. 1, 01.01.2012, p. 95-98.

Research output: Contribution to journalArticle

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