Cefuroxime axetil solid dispersions prepared using solution enhanced dispersion by supercritical fluids

Seoung Wook Jun, Min Soo Kim, Guk Hyun Jo, Sibeum Lee, Jong Soo Woo, Jeong Sook Park, Sung Joo Hwang

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35 Citations (Scopus)

Abstract

Cefuroxime axetil (CA) solid dispersions with HPMC 2910/PVP K-30 were prepared using solution enhanced dispersion by supercritical fluids (SEDS) in an effort to increase the dissolution rate of poorly water-soluble drugs. Their physicochemical properties in solid state were characterized by differential scanning calorimeter (DSC), powder X-ray diffraction (PXRD), Fourier transform infrared spectrometry (FT-IR) and scanning electron microscopy. No endothermic and characteristic diffraction peaks corresponding to CA were observed for the solid dispersions in DSC and PXRD. FTIR analysis demonstrated the presence of intermolecular hydrogen bonds between CA and HPMC 2910/PVP K-30 in solid dispersions, resulting in the formation of amorphous or non-crystalline CA. Dissolution studies indicated that the dissolution rates were remarkably increased in solid dispersions compared with those in the physical mixture and drug alone. In conclusion, an amorphous or non-crystalline CA solid dispersion prepared using SEDS could be very useful for the formulation of solid dosage forms.

Original languageEnglish
Pages (from-to)1529-1537
Number of pages9
JournalJournal of Pharmacy and Pharmacology
Volume57
Issue number12
DOIs
Publication statusPublished - 2005 Dec 1

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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