Cell-based biosensor system using micropatterned polymer nanofiber

Hyun Jong Lee, Eunji Jang, Saemi Park, P. S.Keshava Murthy, Won Gun Koh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

In this study, to improve efficiency and functionality of cell-based biosensor microarrays, we introduced nanotopographical features on cell adhesive region. Micropatterned surface was created by poly (ethylene glycol) (PEG) hydrogel microstructures via photolithography. Nano-topographical features were introduced using polymeric nanofibers which were produced by electrospinning technique. Combining PEG hydrogel microstructure and polymeric nanofibers created a clear contrast between adhesion resist hydrogel walls and adhesion promoting nanofiber surfaces. When mammalian cells were seeded onto micropatterned nanostructure, cells only selectively adhered to nanofiber maintaining their viability, while adherent cells were not present on the hydrogel wall.

Original languageEnglish
Title of host publicationINEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings
Pages419-420
Number of pages2
DOIs
Publication statusPublished - 2010 May 5
Event2010 3rd International Nanoelectronics Conference, INEC 2010 - Hongkong, China
Duration: 2010 Jan 32010 Jan 8

Publication series

NameINEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings

Other

Other2010 3rd International Nanoelectronics Conference, INEC 2010
CountryChina
CityHongkong
Period10/1/310/1/8

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All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

Cite this

Lee, H. J., Jang, E., Park, S., Murthy, P. S. K., & Koh, W. G. (2010). Cell-based biosensor system using micropatterned polymer nanofiber. In INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings (pp. 419-420). [5424508] (INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings). https://doi.org/10.1109/INEC.2010.5424508