Cell-based biosensor system using micropatterned polymer nanofiber

Hyun Jong Lee; Eunji Jang; Saemi Park; P. S.Keshava Murthy; Won Gun Koh

doi:10.1109/INEC.2010.5424508

Cell-based biosensor system using micropatterned polymer nanofiber

Hyun Jong Lee, Eunji Jang, Saemi Park, P. S.Keshava Murthy, Won Gun Koh

Department of Chemical and Biomolecular Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Abstract

In this study, to improve efficiency and functionality of cell-based biosensor microarrays, we introduced nanotopographical features on cell adhesive region. Micropatterned surface was created by poly (ethylene glycol) (PEG) hydrogel microstructures via photolithography. Nano-topographical features were introduced using polymeric nanofibers which were produced by electrospinning technique. Combining PEG hydrogel microstructure and polymeric nanofibers created a clear contrast between adhesion resist hydrogel walls and adhesion promoting nanofiber surfaces. When mammalian cells were seeded onto micropatterned nanostructure, cells only selectively adhered to nanofiber maintaining their viability, while adherent cells were not present on the hydrogel wall.

Original language	English
Title of host publication	INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings
Pages	419-420
Number of pages	2
DOIs	https://doi.org/10.1109/INEC.2010.5424508
Publication status	Published - 2010
Event	2010 3rd International Nanoelectronics Conference, INEC 2010 - Hongkong, China Duration: 2010 Jan 3 → 2010 Jan 8

Publication series

Name	INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings

Other

Other	2010 3rd International Nanoelectronics Conference, INEC 2010
Country	China
City	Hongkong
Period	10/1/3 → 10/1/8

All Science Journal Classification (ASJC) codes

Electrical and Electronic Engineering

Access to Document

10.1109/INEC.2010.5424508

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Cite this

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title = "Cell-based biosensor system using micropatterned polymer nanofiber",

abstract = "In this study, to improve efficiency and functionality of cell-based biosensor microarrays, we introduced nanotopographical features on cell adhesive region. Micropatterned surface was created by poly (ethylene glycol) (PEG) hydrogel microstructures via photolithography. Nano-topographical features were introduced using polymeric nanofibers which were produced by electrospinning technique. Combining PEG hydrogel microstructure and polymeric nanofibers created a clear contrast between adhesion resist hydrogel walls and adhesion promoting nanofiber surfaces. When mammalian cells were seeded onto micropatterned nanostructure, cells only selectively adhered to nanofiber maintaining their viability, while adherent cells were not present on the hydrogel wall.",

author = "Lee, {Hyun Jong} and Eunji Jang and Saemi Park and Murthy, {P. S.Keshava} and Koh, {Won Gun}",

year = "2010",

doi = "10.1109/INEC.2010.5424508",

language = "English",

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pages = "419--420",

booktitle = "INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings",

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Lee, HJ, Jang, E, Park, S, Murthy, PSK & Koh, WG 2010, Cell-based biosensor system using micropatterned polymer nanofiber. in INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings., 5424508, INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings, pp. 419-420, 2010 3rd International Nanoelectronics Conference, INEC 2010, Hongkong, China, 10/1/3. https://doi.org/10.1109/INEC.2010.5424508

Cell-based biosensor system using micropatterned polymer nanofiber. / Lee, Hyun Jong; Jang, Eunji; Park, Saemi; Murthy, P. S.Keshava; Koh, Won Gun.

INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings. 2010. p. 419-420 5424508 (INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Cell-based biosensor system using micropatterned polymer nanofiber

AU - Lee, Hyun Jong

AU - Jang, Eunji

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AU - Murthy, P. S.Keshava

AU - Koh, Won Gun

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AB - In this study, to improve efficiency and functionality of cell-based biosensor microarrays, we introduced nanotopographical features on cell adhesive region. Micropatterned surface was created by poly (ethylene glycol) (PEG) hydrogel microstructures via photolithography. Nano-topographical features were introduced using polymeric nanofibers which were produced by electrospinning technique. Combining PEG hydrogel microstructure and polymeric nanofibers created a clear contrast between adhesion resist hydrogel walls and adhesion promoting nanofiber surfaces. When mammalian cells were seeded onto micropatterned nanostructure, cells only selectively adhered to nanofiber maintaining their viability, while adherent cells were not present on the hydrogel wall.

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BT - INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings

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Y2 - 3 January 2010 through 8 January 2010

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