TY - GEN
T1 - Cell-based biosensor system using micropatterned polymer nanofiber
AU - Lee, Hyun Jong
AU - Jang, Eunji
AU - Park, Saemi
AU - Murthy, P. S.Keshava
AU - Koh, Won Gun
PY - 2010
Y1 - 2010
N2 - In this study, to improve efficiency and functionality of cell-based biosensor microarrays, we introduced nanotopographical features on cell adhesive region. Micropatterned surface was created by poly (ethylene glycol) (PEG) hydrogel microstructures via photolithography. Nano-topographical features were introduced using polymeric nanofibers which were produced by electrospinning technique. Combining PEG hydrogel microstructure and polymeric nanofibers created a clear contrast between adhesion resist hydrogel walls and adhesion promoting nanofiber surfaces. When mammalian cells were seeded onto micropatterned nanostructure, cells only selectively adhered to nanofiber maintaining their viability, while adherent cells were not present on the hydrogel wall.
AB - In this study, to improve efficiency and functionality of cell-based biosensor microarrays, we introduced nanotopographical features on cell adhesive region. Micropatterned surface was created by poly (ethylene glycol) (PEG) hydrogel microstructures via photolithography. Nano-topographical features were introduced using polymeric nanofibers which were produced by electrospinning technique. Combining PEG hydrogel microstructure and polymeric nanofibers created a clear contrast between adhesion resist hydrogel walls and adhesion promoting nanofiber surfaces. When mammalian cells were seeded onto micropatterned nanostructure, cells only selectively adhered to nanofiber maintaining their viability, while adherent cells were not present on the hydrogel wall.
UR - http://www.scopus.com/inward/record.url?scp=77951664547&partnerID=8YFLogxK
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U2 - 10.1109/INEC.2010.5424508
DO - 10.1109/INEC.2010.5424508
M3 - Conference contribution
AN - SCOPUS:77951664547
SN - 9781424435449
T3 - INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings
SP - 419
EP - 420
BT - INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings
T2 - 2010 3rd International Nanoelectronics Conference, INEC 2010
Y2 - 3 January 2010 through 8 January 2010
ER -