Cell Nucleus-Targeting Zwitterionic Carbon Dots

Yun Kyung Jung, Eeseul Shin, Byeong Su Kim

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)

Abstract

An innovative nucleus-targeting zwitterionic carbon dot (CD) vehicle has been developed for anticancer drug delivery and optical monitoring. The zwitterionic functional groups of the CDs introduced by a simple one-step synthesis using β-alanine as a passivating and zwitterionic ligand allow cytoplasmic uptake and subsequent nuclear translocation of the CDs. Moreover, multicolor fluorescence improves the accuracy of the CDs as an optical code. The CD-based drug delivery system constructed by non-covalent grafting of doxorubicin, exhibits superior antitumor efficacy owing to enhanced nuclear delivery in vitro and tumor accumulation in vivo, resulting in highly effective tumor growth inhibition. Since the zwitterionic CDs are highly biocompatible and effectively translocated into the nucleus, it provides a compelling solution to a multifunctional nanoparticle for substantially enhanced nuclear uptake of drugs and optical monitoring of translocation.

Original languageEnglish
Article number18807
JournalScientific reports
Volume5
DOIs
Publication statusPublished - 2015 Dec 22

Bibliographical note

Funding Information:
The authors thank Professor Pann-Ghill Suh of UNIST for providing 4T1-luc2 murine breast cancer cell and Professor Hu Young Jeong for helping to obtain high-quality TEM images. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2015R1A1A3A04001437) and funded by the Korea government (MSIP) (No. 2010-0028684).

All Science Journal Classification (ASJC) codes

  • General

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