Cell pattern in the Arabidopsis root epidermis determined by lateral inhibition with feedback

Myeong Min Lee, John Schiefelbein

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

In the root epidermis of Arabidopsis, hair and nonhair cell types are specified in a distinct position-dependent pattern. Here, we show that transcriptional feedback loops between the WEREWOLF (WER), CAPRICE (CPC), and GLABRA2. (GL2) genes help to establish this pattern. Positional cues bias the expression of the WER MYB gene, leading to the induction of CPC and GL2 in cells located in a particular position (N) and adoption of the nonhair fate. The truncated MYB encoded by CPC mediates a lateral inhibition mechanism to negatively regulate WER, GL2, and its own gene in the alternative position (H) to induce the hair fate. These results provide a molecular genetic framework for understanding the determination of a cell-type pattern in plants.

Original languageEnglish
Pages (from-to)611-618
Number of pages8
JournalPlant Cell
Volume14
Issue number3
DOIs
Publication statusPublished - 2002 Jan 1

Fingerprint

epidermis (animal)
Arabidopsis
Epidermis
Genes
Feedback
Hair
trichomes
genes
cells
molecular genetics
Cues
Molecular Biology
Legendary Creatures
Inhibition (Psychology)

All Science Journal Classification (ASJC) codes

  • Plant Science
  • Cell Biology

Cite this

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Cell pattern in the Arabidopsis root epidermis determined by lateral inhibition with feedback. / Lee, Myeong Min; Schiefelbein, John.

In: Plant Cell, Vol. 14, No. 3, 01.01.2002, p. 611-618.

Research output: Contribution to journalArticle

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