Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging

Kwangmeyung Kim, Misu Lee, Hyungkyu Park, Jong Ho Kim, Sungwon Kim, Hesson Chung, Kuiwon Choi, In San Kim, Baik L. Seong, Ick Chan Kwon

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194 Citations (Scopus)

Abstract

Here, we report for the first time cell-permeable and biocompatible polymeric nanoparticles consisting of a polymer conjugated to a near-infrared (NIR) fluorescence (Cy5.5)-linked effector caspase-specific peptide. The close spatial proximity of the NIR fluorochromes in polymeric nanoparticles results in an autoquenched state, but polymer nanoparticles give rise to strong NIR fluorescence signal under apoptotic cells. Thus, the smart polymeric nanoparticle developed here is an attractive probe for real-time imaging of apoptosis in single cells.

Original languageEnglish
Pages (from-to)3490-3491
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number11
DOIs
Publication statusPublished - 2006 Mar 22

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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  • Cite this

    Kim, K., Lee, M., Park, H., Kim, J. H., Kim, S., Chung, H., Choi, K., Kim, I. S., Seong, B. L., & Kwon, I. C. (2006). Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging. Journal of the American Chemical Society, 128(11), 3490-3491. https://doi.org/10.1021/ja057712f