Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging

Kwangmeyung Kim, Misu Lee, Hyungkyu Park, Jong Ho Kim, Sungwon Kim, Hesson Chung, Kuiwon Choi, In San Kim, Baik L. Seong, Ick Chan Kwon

Research output: Contribution to journalArticle

190 Citations (Scopus)

Abstract

Here, we report for the first time cell-permeable and biocompatible polymeric nanoparticles consisting of a polymer conjugated to a near-infrared (NIR) fluorescence (Cy5.5)-linked effector caspase-specific peptide. The close spatial proximity of the NIR fluorochromes in polymeric nanoparticles results in an autoquenched state, but polymer nanoparticles give rise to strong NIR fluorescence signal under apoptotic cells. Thus, the smart polymeric nanoparticle developed here is an attractive probe for real-time imaging of apoptosis in single cells.

Original languageEnglish
Pages (from-to)3490-3491
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number11
DOIs
Publication statusPublished - 2006 Mar 22

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Cell death
Nanoparticles
Apoptosis
Imaging techniques
Infrared radiation
Polymers
Fluorescence
Effector Caspases
Conjugated polymers
Fluorescent Dyes
Peptides
Cells

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Kim, K., Lee, M., Park, H., Kim, J. H., Kim, S., Chung, H., ... Kwon, I. C. (2006). Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging. Journal of the American Chemical Society, 128(11), 3490-3491. https://doi.org/10.1021/ja057712f
Kim, Kwangmeyung ; Lee, Misu ; Park, Hyungkyu ; Kim, Jong Ho ; Kim, Sungwon ; Chung, Hesson ; Choi, Kuiwon ; Kim, In San ; Seong, Baik L. ; Kwon, Ick Chan. / Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging. In: Journal of the American Chemical Society. 2006 ; Vol. 128, No. 11. pp. 3490-3491.
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Kim, K, Lee, M, Park, H, Kim, JH, Kim, S, Chung, H, Choi, K, Kim, IS, Seong, BL & Kwon, IC 2006, 'Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging', Journal of the American Chemical Society, vol. 128, no. 11, pp. 3490-3491. https://doi.org/10.1021/ja057712f

Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging. / Kim, Kwangmeyung; Lee, Misu; Park, Hyungkyu; Kim, Jong Ho; Kim, Sungwon; Chung, Hesson; Choi, Kuiwon; Kim, In San; Seong, Baik L.; Kwon, Ick Chan.

In: Journal of the American Chemical Society, Vol. 128, No. 11, 22.03.2006, p. 3490-3491.

Research output: Contribution to journalArticle

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AU - Kim, Kwangmeyung

AU - Lee, Misu

AU - Park, Hyungkyu

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AU - Kim, Sungwon

AU - Chung, Hesson

AU - Choi, Kuiwon

AU - Kim, In San

AU - Seong, Baik L.

AU - Kwon, Ick Chan

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