Cell therapy with bone marrow cells for myocardial regeneration

Hyongbum Kim, Sung Whan Kim, Douglas Nam, Sinae Kim, Young Sup Yoon

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Cell therapy has tremendous potential for the damaged heart, which has limited self-renewing capability. Bone marrow (BM) cells are attractive for cell therapy, as they contain diverse stem and progenitor cell populations that can give rise to various cell types, including cardiomyocytes, endothelial cells, and smooth muscle cells. Studies have shown BM cells to be safe and efficacious in the treatment of myocardial infarction. Possible therapeutic mechanisms mediated by both host and transplanted cells include cardiomyogenesis, neovascularization, and attenuation of adverse remodeling. In this review, different stem and progenitor cells in the bone marrow and their application in cell therapy are reviewed, and evidence for their therapeutic mechanisms is discussed.

Original languageEnglish
Pages (from-to)1897-1911
Number of pages15
JournalAntioxidants and Redox Signaling
Volume11
Issue number8
DOIs
Publication statusPublished - 2009 Aug 1

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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