Cellular responses of vascular endothelial cells on surface modified polyurethane films grafted electrospun PLGA fiber with microwave-induced plasma at atmospheric pressure

Bong Joo Park, Hyok Jin Seo, Jungsung Kim, Hye Lee Kim, Jeong Koo Kim, Jae Bong Choi, Inho Han, Soon O. Hyun, Kie Hyung Chung, Jongchul Park

Research output: Contribution to journalArticle

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Abstract

To improve cell-material interaction, the surface modification of materials in tissue engineering is carried out by change in chemical structure or by ion-beam irradiation and plasma treatment. The modifications of biological surface, such as coating or peptide grafting, may also enhance endothelialization of biomaterial surfaces. In this study, the surface of polyurethane (PU) grafted with electrospun poly (d,. l-lactic-co-glycolic acid) (PLGA) fibers (PU/PLGA) was modified with microwave-induced argon plasma and the PU/PLGA films with plasma modified surface were examined to investigate their effects on the attachment and growth of human umbilical vein endothelial cells (HUVECs) for applications in vascular tissue engineering. In comparison with the control, PU film with microwave plasma modified surface was more hydrophilic and the roughness of the surface was enhanced. Furthermore, the plasma treatment on PU/PLGA has significantly increased the attachment of HUVECs and proliferation of the cells was slightly enhanced as well. These results suggested that the surface of PU/PLGA films modified with plasma treatment can be effectively used as a biocompatible material for vascular tissue engineering application, although more in-depth studies are needed.

Original languageEnglish
JournalSurface and Coatings Technology
Volume205
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2010 Dec 25

Fingerprint

Polyurethanes
Endothelial cells
Atmospheric pressure
atmospheric pressure
Microwaves
Plasmas
microwaves
fibers
Fibers
tissue engineering
Tissue engineering
glycolic acid
Biocompatible Materials
Biomaterials
veins
attachment
Argon
Beam plasma interactions
polylactic acid-polyglycolic acid copolymer
argon plasma

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Surfaces and Interfaces

Cite this

Park, Bong Joo ; Seo, Hyok Jin ; Kim, Jungsung ; Kim, Hye Lee ; Kim, Jeong Koo ; Choi, Jae Bong ; Han, Inho ; Hyun, Soon O. ; Chung, Kie Hyung ; Park, Jongchul. / Cellular responses of vascular endothelial cells on surface modified polyurethane films grafted electrospun PLGA fiber with microwave-induced plasma at atmospheric pressure. In: Surface and Coatings Technology. 2010 ; Vol. 205, No. SUPPL. 1.
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abstract = "To improve cell-material interaction, the surface modification of materials in tissue engineering is carried out by change in chemical structure or by ion-beam irradiation and plasma treatment. The modifications of biological surface, such as coating or peptide grafting, may also enhance endothelialization of biomaterial surfaces. In this study, the surface of polyurethane (PU) grafted with electrospun poly (d,. l-lactic-co-glycolic acid) (PLGA) fibers (PU/PLGA) was modified with microwave-induced argon plasma and the PU/PLGA films with plasma modified surface were examined to investigate their effects on the attachment and growth of human umbilical vein endothelial cells (HUVECs) for applications in vascular tissue engineering. In comparison with the control, PU film with microwave plasma modified surface was more hydrophilic and the roughness of the surface was enhanced. Furthermore, the plasma treatment on PU/PLGA has significantly increased the attachment of HUVECs and proliferation of the cells was slightly enhanced as well. These results suggested that the surface of PU/PLGA films modified with plasma treatment can be effectively used as a biocompatible material for vascular tissue engineering application, although more in-depth studies are needed.",
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Cellular responses of vascular endothelial cells on surface modified polyurethane films grafted electrospun PLGA fiber with microwave-induced plasma at atmospheric pressure. / Park, Bong Joo; Seo, Hyok Jin; Kim, Jungsung; Kim, Hye Lee; Kim, Jeong Koo; Choi, Jae Bong; Han, Inho; Hyun, Soon O.; Chung, Kie Hyung; Park, Jongchul.

In: Surface and Coatings Technology, Vol. 205, No. SUPPL. 1, 25.12.2010.

Research output: Contribution to journalArticle

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AU - Park, Bong Joo

AU - Seo, Hyok Jin

AU - Kim, Jungsung

AU - Kim, Hye Lee

AU - Kim, Jeong Koo

AU - Choi, Jae Bong

AU - Han, Inho

AU - Hyun, Soon O.

AU - Chung, Kie Hyung

AU - Park, Jongchul

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N2 - To improve cell-material interaction, the surface modification of materials in tissue engineering is carried out by change in chemical structure or by ion-beam irradiation and plasma treatment. The modifications of biological surface, such as coating or peptide grafting, may also enhance endothelialization of biomaterial surfaces. In this study, the surface of polyurethane (PU) grafted with electrospun poly (d,. l-lactic-co-glycolic acid) (PLGA) fibers (PU/PLGA) was modified with microwave-induced argon plasma and the PU/PLGA films with plasma modified surface were examined to investigate their effects on the attachment and growth of human umbilical vein endothelial cells (HUVECs) for applications in vascular tissue engineering. In comparison with the control, PU film with microwave plasma modified surface was more hydrophilic and the roughness of the surface was enhanced. Furthermore, the plasma treatment on PU/PLGA has significantly increased the attachment of HUVECs and proliferation of the cells was slightly enhanced as well. These results suggested that the surface of PU/PLGA films modified with plasma treatment can be effectively used as a biocompatible material for vascular tissue engineering application, although more in-depth studies are needed.

AB - To improve cell-material interaction, the surface modification of materials in tissue engineering is carried out by change in chemical structure or by ion-beam irradiation and plasma treatment. The modifications of biological surface, such as coating or peptide grafting, may also enhance endothelialization of biomaterial surfaces. In this study, the surface of polyurethane (PU) grafted with electrospun poly (d,. l-lactic-co-glycolic acid) (PLGA) fibers (PU/PLGA) was modified with microwave-induced argon plasma and the PU/PLGA films with plasma modified surface were examined to investigate their effects on the attachment and growth of human umbilical vein endothelial cells (HUVECs) for applications in vascular tissue engineering. In comparison with the control, PU film with microwave plasma modified surface was more hydrophilic and the roughness of the surface was enhanced. Furthermore, the plasma treatment on PU/PLGA has significantly increased the attachment of HUVECs and proliferation of the cells was slightly enhanced as well. These results suggested that the surface of PU/PLGA films modified with plasma treatment can be effectively used as a biocompatible material for vascular tissue engineering application, although more in-depth studies are needed.

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