Cellular senescence and inflammaging in the skin microenvironment

Young In Lee, Sooyeon Choi, Won Seok Roh, Ju Hee Lee, Tae Gyun Kim

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


Cellular senescence and aging result in a reduced ability to manage persistent types of inflammation. Thus, the chronic low-level inflammation associated with aging phenotype is called “inflammaging”. Inflammaging is not only related with age-associated chronic systemic diseases such as cardiovascular disease and diabetes, but also skin aging. As the largest organ of the body, skin is continuously exposed to external stressors such as UV radiation, air particulate matter, and human microbiome. In this review article, we present mechanisms for accumulation of senescence cells in different compartments of the skin based on cell types, and their association with skin resident immune cells to describe changes in cutaneous immunity during the aging process.

Original languageEnglish
Article number3849
JournalInternational journal of molecular sciences
Issue number8
Publication statusPublished - 2021 Apr 2

Bibliographical note

Funding Information:
Funding: This research was supported by a Basic Science Research Program through the National Research Foundation of Republic of Korea funded by the Ministry of Education (2019R1A6A1A03032869) and Ministry of Science and Information and Communications Technology (2018R1A5A2025079, 2019M3A9E8022135 and 2020R1C1C1014513), by a Korea Health Technology R&D Project through the Korea Health Industry Development Institute funded by the Ministry of Health and Welfare (HP20C0019 and HP20C0171) and Korea Centers for Disease Control and Prevention (2020-ER6714-00), and by the Yonsei University Faculty Research Grant (6-2020-0081).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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