Cellulose nanocrystals as support nanomaterials for dual droplet-based freeform 3D printing

Hyung Sun Yoon; Kyungjik Yang; Young Min Kim; Keonwook Nam; Young Hoon Roh

doi:10.1016/j.carbpol.2021.118469

Cellulose nanocrystals as support nanomaterials for dual droplet-based freeform 3D printing

Hyung Sun Yoon, Kyungjik Yang, Young Min Kim, Keonwook Nam, Young Hoon Roh

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The selection of sacrificial support materials is important in the fabrication of complex freeform structures. In this study, a dual droplet-based, freeform 3D printing method for pseudoplastic alginate biomaterial inks was developed using Bingham plastic cellulose nanocrystals (CNCs) as support nanomaterials. CNCs-CaCl₂ mixture compositions and alginate concentrations were varied to enhance printability with rheological properties of shape fidelity and structural stability. The mixtures supported the shape of alginate and allowed CaCl₂ diffusion-based cross-linking during 3D printing. The hydrogels showed rheological and physicochemical properties similar to those of pure alginate hydrogel, as CNCs were removed during post-printing processing. BSA-loaded multi-layered spheres, freeform 3D-printed for oral protein drug delivery, protected BSA in the gastric environment and provided controlled and sustained release of BSA into the intestinal environment as layer width and alginate concentration increased. This method can facilitate freeform 3D printing of diverse pseudoplastic biomaterial inks for biomedical applications.

Original language	English
Article number	118469
Journal	Carbohydrate Polymers
Volume	272
DOIs	https://doi.org/10.1016/j.carbpol.2021.118469
Publication status	Published - 2021 Nov 15

Bibliographical note

Funding Information:
This research was financially supported by the Ministry of Small and Medium-sized Enterprises (SMEs) and Startups (MSS), Korea, under the “Regional Specialized Industry Development Plus Program (R&D, S3006131)” supervised by the Korea Institute for Advancement of Technology (KIAT). The work was supported in part by Brain Korea 21 (BK21) FOUR program. K.Y. was supported by the NRF-2017-Global Ph.D. Fellowship Program.

Funding Information:
This research was financially supported by the Ministry of Small and Medium-sized Enterprises (SMEs) and Startups (MSS), Korea, under the “Regional Specialized Industry Development Plus Program (R&D, S3006131 )” supervised by the Korea Institute for Advancement of Technology (KIAT). The work was supported in part by Brain Korea 21 (BK21) FOUR program. K.Y. was supported by the NRF -2017-Global Ph.D. Fellowship Program.

Publisher Copyright:
© 2021 Elsevier Ltd

All Science Journal Classification (ASJC) codes

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.carbpol.2021.118469

Cite this

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abstract = "The selection of sacrificial support materials is important in the fabrication of complex freeform structures. In this study, a dual droplet-based, freeform 3D printing method for pseudoplastic alginate biomaterial inks was developed using Bingham plastic cellulose nanocrystals (CNCs) as support nanomaterials. CNCs-CaCl2 mixture compositions and alginate concentrations were varied to enhance printability with rheological properties of shape fidelity and structural stability. The mixtures supported the shape of alginate and allowed CaCl2 diffusion-based cross-linking during 3D printing. The hydrogels showed rheological and physicochemical properties similar to those of pure alginate hydrogel, as CNCs were removed during post-printing processing. BSA-loaded multi-layered spheres, freeform 3D-printed for oral protein drug delivery, protected BSA in the gastric environment and provided controlled and sustained release of BSA into the intestinal environment as layer width and alginate concentration increased. This method can facilitate freeform 3D printing of diverse pseudoplastic biomaterial inks for biomedical applications.",

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Cellulose nanocrystals as support nanomaterials for dual droplet-based freeform 3D printing

Abstract

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