Central nervous system-specific knockout of steroidogenic factor 1

Ki Woo Kim, Liping Zhao, Keith L. Parker

Research output: Contribution to journalReview articlepeer-review

27 Citations (Scopus)

Abstract

Steroidogenic factor 1 (SF-1) is a nuclear receptor that plays important roles in the hypothalamus-pituitary-steroidogenic organ axis. Global knockout studies in mice revealed the essential in vivo roles of SF-1 in the ventromedial hypothalamic (VMH) nucleus, adrenal glands, and gonads. One limitation of global SF-1 knockout mice is their early postnatal death from adrenocortical insufficiency. To overcome limitations of the global knockout mice and to delineate the roles of SF-1 in the brain, we used Cre/loxP recombination technology to genetically ablate SF-1 specifically in the central nervous system (CNS). Mice with CNS-specific knockout of SF-1 mediated by nestin-Cre showed increased anxiety-like behavior, revealing a crucial role of SF-1 in a complex behavioral phenotype. Our studies with CNS-specific SF-1 KO mice also defined roles of SF-1 in regulating the VMH expression of target genes implicated in anxiety and energy homeostasis. Therefore, this review will focus on our recent studies defining the functional roles of SF-1 in the VMH linked to anxiety and energy homeostasis.

Original languageEnglish
Pages (from-to)132-136
Number of pages5
JournalMolecular and Cellular Endocrinology
Volume300
Issue number1-2
DOIs
Publication statusPublished - 2009 Mar 5

Bibliographical note

Funding Information:
This work was supported by NIH grants DK54480 and 1RL1DK081185-01 to K.L.P. We thank Drs. Streamson Chua and Young-Hwan Jo for helpful discussions and for performing electrophysiological studies included in Kim et al. (2008) .

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Fingerprint

Dive into the research topics of 'Central nervous system-specific knockout of steroidogenic factor 1'. Together they form a unique fingerprint.

Cite this